Parcourir par sujet "psoriatic arthritis"

2021 EULAR recommendations for the implementation of self-management strategies in patients with inflammatory arthritis

Nikiphorou E., Santos E.J.F., Marques A., Böhm P., Bijlsma J.W.J., Daien C.I., Esbensen B.A., Ferreira R.J.O., Fragoulis G.E., Holmes P., McBain H., Metsios G.S., Moe R.H., Stamm T.A., De Thurah A., Zabalan C., Carmona L., Bosworth A. (2021)

Background: An important but often insufficient aspect of care in people with inflammatory arthritis (IA) is empowering patients to acquire a good understanding of their disease and building their ability to deal effectively ...

Acro-osteolysis

Botou A., Bangeas A., Alexiou I., Sakkas L.I. (2017)

Acro-osteolysis is an osteolysis of the distal phalanges of the hands and feet and can affect the terminal tuft or the shaft of the distal phalanx (transverse or band acro-osteolysis). It is often associated with distal ...

Apremilast increases IL-10-producing regulatory B cells and decreases proinflammatory T cells and innate cells in psoriatic arthritis and psoriasis

Mavropoulos A., Zafiriou E., Simopoulou T., Brotis A.G., Liaskos C., Roussaki-Schulze A., Katsiari C.G., Bogdanos D.P., Sakkas L.I. (2019)

Objectives: Psoriatic arthritis (PsA) and psoriasis are immune-mediated inflammatory diseases sharing common immunological mechanisms. Regulatory B cells (Breg cells) producing IL-10 (B10 cells), a critical anti-inflammatory ...

Are psoriasis and psoriatic arthritis the same disease? The IL-23/IL-17 axis data

Sakkas L.I., Bogdanos D.P. (2017)

Psoriatic arthritis (PsA) is a psoriasis (Ps)-associated inflammatory joint disease that affects peripheral joints, entheses, spine, and eyes. PsA and Ps are likely to be the same disease. PsA develops in nearly 70% of ...

Autoantibodies against specific nuclear antigens are present in psoriatic disease and are diminished by secukinumab

Patrikiou E., Liaskos C., Mavropoulos A., Ntavari N., Gkoutzourelas A., Simopoulou T., Fechner K., Scheper T., Meyer W., Katsiari C.G., Roussaki-Schulze A., Zafiriou E., Sakkas L.I., Bogdanos D.P. (2020)

Anti-nuclear antibodies (ANA) are frequently detected in patients with psoriasis (Ps) and psoriatic arthritis (PsA), but their target autoantigens remain unknown. We assessed antibody (ab) reactivity against 23 known nuclear ...

Children with psoriasis and COVID-19: factors associated with an unfavourable COVID-19 course, and the impact of infection on disease progression (Chi-PsoCov registry)

Zitouni J., Bursztejn A.-C., Belloni Fortina A., Beauchet A., Di Lernia V., Lesiak A., Thomas J., Topkarci Z., Murashkin N., Brzezinski P., Torres T., Chiriac A., Luca C., McPherson T., Akinde M., Maruani A., Epishev R., Vidaurri de la Cruz H., Luna P.C., Amy de la Bretêque M., Lasek A., Bourrat E., Bachelerie M., Mallet S., Steff M., Bellissen A., Neri I., Zafiriou E., van den Reek J.M.P.A., Sonkoly E., Mahil S.K., Smith C.H., Flohr C., Bachelez H., Mahé E., the Groupe de Recherche sur le Psoriasis (GrPso) of the Societe Francaise de Dermatologie, the Groupe de recherche de la Societe Francaise de Dermatologie Pediatrique (GR SFDP), the PsoProtect study group, the British Society of Paediatric Dermatology (BPSD), and the Societa Italiana di Dermatologia Pediatrica (S.I.Der.P.) (2022)

Background: The COVID-19 pandemic has raised questions regarding the management of chronic skin diseases, especially in patients on systemic treatments. Data concerning the use of biologics in adults with psoriasis are ...

Curcumin mediates attenuation of pro-inflammatory interferon γ and interleukin 17 cytokine responses in psoriatic disease, strengthening its role as a dietary immunosuppressant

Skyvalidas D.Ν., Mavropoulos A., Tsiogkas S., Dardiotis E., Liaskos C., Mamuris Z., Roussaki-Schulze A., Sakkas L.I., Zafiriou E., Bogdanos D.P. (2020)

Curcumin exhibits anti-inflammatory properties and has been used for centuries in traditional medicine and as dietary supplement. Data from clinical trials has strengthened the notion that curcumin may exert an anti-inflammatory ...

Delphinidin diminishes in vitro interferon-γ and interleukin-17 producing cells in patients with psoriatic disease

Tsiogkas S.G., Mavropoulos Α., Skyvalidas D.N., Patrikiou E., Ntavari N., Daponte A.I., Grammatikopoulou M.G., Dardiotis E., Roussaki-Schulze A.-V., Sakkas L.I., Zafiriou E., Bogdanos D.P. (2022)

The anthocyanidin delphinidin reduces psoriasiform lesions and inflammatory mediators in human cell culture systems. Its role in psoriatic disease has not yet been investigated. We assessed delphinidin’s in vitro ...

Depression and Obesity in Patients With Psoriasis and Psoriatic Arthritis: Is IL-17-Mediated Immune Dysregulation the Connecting Link?

Zafiriou E., Daponte A.I., Siokas V., Tsigalou C., Dardiotis E., Bogdanos D.P. (2021)

Patients with psoriasis are frequently obese and experience anxiety or suffer from depressive disorders. The immunopathogenesis of psoriasis and indeed psoriatic arthritis is largely based on the pivotal role of IL-17/IL-23 ...

The effect of Apremilast on signal transduction and IL-10 production in CD39high regulatory B cells in patients with psoriatic arthritis

Sakkas L.I., Mavropoulos A., Zafiriou E., Roussaki-Schulze A., Bogdanos D.P. (2018)

Background. IL-10-producing regulatory B cells (Bregs) are of great importance in autoimmunity, as they inhibit proinflammatory T cells. We have shown that IL-10-producing Bregs in psoriatic arthritis(PsA) were decreased ...

Hematogenous spinal infection in Central Greece

Sakkas, L. I.; Davas, E. M.; Kapsalaki, E.; Boulbou, M.; Makaritsis, K.; Alexiou, I.; Tsikrikas, T.; Stathakis, N. (2009)

STUDY DESIGN.: We retrospectively analyzed spinal infection (SpI), in a teaching Hospital, in Central Greece. OBJECTIVE.: To study presentation, etiology, and outcome of SpI in Central Greece. SUMMARY OF BACKGROUND DATA.: ...

IL-10 producing Bregs are impaired in psoriatic arthritis and psoriasis and inversely correlate with IL-17- and IFNγ-producing T cells

Mavropoulos A., Varna A., Zafiriou E., Liaskos C., Alexiou I., Roussaki-Schulze A., Vlychou M., Katsiari C., Bogdanos D.P., Sakkas L.I. (2017)

Our aim was to study CD19(+)CD27(+)CD24(high) memory and CD19(+)CD24(high)CD38(high) transitional and IL-10 + Breg cells, known to inhibit Th1 and Th17 cells in experimental arthritis, in psoriatic arthritis (PsA) and ...

IL-35: a new immunomodulator in autoimmune rheumatic diseases

Sakkas L.I., Mavropoulos A., Perricone C., Bogdanos D.P. (2018)

IL-35 is a relatively new cytokine that emerges as an important immunomodulator. IL-35 belongs to IL-12 cytokine family that includes IL-12, IL-23, IL-27, and IL-35. These cytokines are heterodimers that share subunits and ...

Interaction between microbiome and host genetics in psoriatic arthritis

Chimenti M.S., Perricone C., Novelli L., Caso F., Costa L., Bogdanos D., Conigliaro P., Triggianese P., Ciccacci C., Borgiani P., Perricone R. (2018)

Psoriatic arthritis (PsA) is a chronic inflammatory joint disease, seen in combination with psoriasis. Both genetic and environmental factors are responsible for the development of PsA, however little is known about the ...

Mini review: New treatments in psoriatic arthritis. Focus on the IL-23/17 Axis

Sakkas L.I., Zafiriou E., Bogdanos D.P. (2019)

Psoriasis, an inflammatory skin disease, and psoriatic arthritis (PsA), an inflammatory arthritis, share clinical, genetic, and pathogenic factors and may be summed as one disease, the psoriatic disease. Interleukin (IL)-17 ...

On the Role of Salt in Immunoregulation and Autoimmunity

Mavropoulos A. (2021)

[No abstract available]

Phosphodiesterase 4 inhibitors in immune-mediated diseases: Mode of action, clinical applications, current and future perspectives

Sakkas L.I., Mavropoulos A., Bogdanos D.P. (2017)

Phosphodiesterase (PDE) 4 is a superfamily of enzymes that catalyze the hydrolysis of cyclic adenosine 3', 5'-monophosphate (cAMP), an intracellular second messenger and regulator of a wide array of genes and proteins. ...

Real-world clinical outcomes of treatment with brodalumab in patients with moderate-to-severe psoriasis: a retrospective, 24-month experience from four academic dermatology centers in Greece

Papadavid E., Zafeiriou E., Georgiou S., Roussaki-Schulze A.-V., Spiliopoulos T., Vryzaki E., Oikonomou C., Drongoula O., Boziou M., Goudouras G., Sfaelos K., Apalla Z., Lazaridou E. (2022)

Objective: To assess the real-world clinical treatment outcomes with brodalumab in patients with moderate-to-severe plaque psoriasis in Greece. Materials and methods: This was a longitudinal, retrospective, real-world ...

Regulatory B cells: New players in inflammatory and autoimmune rheumatic diseases

Sakkas L.I., Daoussis D., Mavropoulos A., Liossis S.-N., Bogdanos D.P. (2019)

Objective: Regulatory B cells (Bregs) are a new subset of B cells with immunoregulatory functions, mainly through IL-10 production. Bregs suppress inflammatory Th1 and Th17 differentiation and induce Tregs suppressing ...

The role of Dickkopf-1 in joint remodeling and fibrosis: A link connecting spondyloarthropathies and scleroderma?

Klavdianou K., Liossis S.-N., Sakkas L., Daoussis D. (2017)

Background Dickkopf-1 (Dkk-1) is a soluble inhibitor of the canonical Wnt pathway, which plays critical roles in embryonic development. Evidence suggests that this molecule regulates several aspects of both bone biology ...