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Πλοήγηση ανά Θέμα "primary sclerosing cholangitis"

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    • Autoantibodies to asialoglycoprotein receptor (ASGPR) in patients with autoimmune liver diseases 

      Villalta, D.; Mytilinaiou, M. G.; Elsner, M.; Hentschel, C.; Cuccato, J.; Somma, V.; Schierack, P.; Roggenbuck, D.; Bogdanos, D. P. (2015)
      Background: The liver asialoglycoprotein receptor (ASGPR) is the only organ-specific autoantigenic target in autoimmune hepatitis (AIH) patients and corresponding autoantibodies (Abs) have been suggested aiding in the ...

    • Decreased serum DNase1-activity in patients with autoimmune liver diseases 

      Gatselis N.K., Vakrakou A.G., Zachou K., Androutsakos T., Azariadis K., Hatzis G., Manoussakis M.N., Dalekos G.N. (2017)
      Deoxyribonuclease1 (DNase1) is involved in chromatin degradation of apoptotic cells. Its deficiency results in accumulation of self-DNA, which in turn may induce inflammation and autoimmunity. We assessed for the first ...

    • Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis 

      Liu, J. Z.; Hov, J. R.; Folseraas, T.; Ellinghaus, E.; Rushbrook, S. M.; Doncheva, N. T.; Andreassen, O. A.; Weersma, R. K.; Weismüller, T. J.; Eksteen, B.; Invernizzi, P.; Hirschfield, G. M.; Gotthardt, D. N.; Pares, A.; Ellinghaus, D.; Shah, T.; Juran, B. D.; Milkiewicz, P.; Rust, C.; Schramm, C.; Muler, T.; Srivastava, B.; Dalekos, G.; Nöthen, M. M.; Herms, S.; Winkelmann, J.; Mitrovic, M.; Braun, F.; Ponsioen, C. Y.; Croucher, P. J. P.; Sterneck, M.; Teufel, A.; Andrew, L. Mason; Saarela, J.; Leppa, V.; Dorfman, R.; Alvaro, D.; Floreani, A.; Onengut-Gumuscu, S.; Rich, S. S.; Thompson, W. K.; Schork, A. J.; Næss, S.; Thomsen, I.; Mayr, G.; König, I. R.; Hveem, K.; Cleynen, I.; Gutierrez-Achury, J.; Ricaño-Ponce, I.; Van Heel, D.; Björnsson, E.; Sandford, R. N.; Durie, P. R.; Melum, E.; Vatn, M. H.; Silverberg, M. S.; Duerr, R. H.; Padyukov, L.; Brand, S.; Sans, M.; Annese, V.; Achkar, J. P.; Boberg, K. M.; Marschall, H. U.; Chazouillères, O.; Bowlus, C. L.; Wijmenga, C.; Schrumpf, E.; Vermeire, S.; Albrecht, M.; Rioux, J. D.; Alexander, G.; Bergquist, A.; Cho, J.; Schreiber, S.; Manns, M. P.; Färkkilä, M.; Dale, A. M.; Chapman, R. W.; Konstantinos, N. Lazaridis; Franke, A.; Anderson, C. A.; Karlsen, T. H. (2013)
      Primary sclerosing cholangitis (PSC) is a severe liver disease of unknown etiology leading to fibrotic destruction of the bile ducts and ultimately to the need for liver transplantation. We compared 3,789 PSC cases of ...

    • Increased cholestatic enzymes in two patients with long-term history of ulcerative colitis: Consider primary biliary cholangitis not always primary sclerosing cholangitis 

      Polychronopoulou E., Lygoura V., Gatselis N.K., Dalekos G.N. (2017)
      Several hepatobiliary disorders have been reported in ulcerative colitis (UC) patients with primary sclerosing cholangitis (PSC) being the most specific. Primary biliary cholangitis (PBC), previously known as primary biliary ...

    • Liver Expression of Sulphotransferase 2A1 Enzyme Is Impaired in Patients with Primary Sclerosing Cholangitis: Lack of the Response to Enhanced Expression of PXR 

      Wunsch E., Klak M., Wasik U., Milkiewicz M., Blatkiewicz M., Urasinska E., Barbier O., Bielicki D., Bogdanos D.P., Elias E., Milkiewicz P. (2015)
      Background/Aim. Sulphotransferase 2A1 (SULT2A1) exerts hepatoprotective effects. Transcription of SULT2A1 gene is induced by pregnane-X-receptor (PXR) and can be repressed by miR-378a-5p. We studied the PXR/SULT2A1 axis ...

    • Occult hepatitis B virus infection in patients with autoimmune liver diseases 

      Georgiadou, S. P.; Zachou, K.; Liaskos, C.; Gabeta, S.; Rigopoulou, E. I.; Dalekos, G. N. (2009)
      Occult hepatitis B virus (HBV) infection is characterized by undetectable serum HBV surface antigen (HBsAg) but detectable HBV-DNA in serum or liver. To determine the prevalence and clinical impact of occult HBV in autoimmune ...

    • Patient Age, Sex, and Inflammatory Bowel Disease Phenotype Associate With Course of Primary Sclerosing Cholangitis 

      Weismüller T.J., Strassburg C.P., Trivedi P.J., Hirschfield G.M., Trivedi P.J., Bergquist A., Said K., Imam M., Lazaridis K.N., Juran B.D., Cheung A., Lindor K.D., Weismüller T.J., Lenzen H., Manns M.P., Ponsioen C.Y., Beuers U., Holm K., Naess S., Karlsen T.H., Schrumpf E., Boberg K.M., Gotthardt D., Rupp C., Färkkilä M.A., Jokelainen K., Marschall H.-U., Benito de Valle M., Thorburn D., Saffioti F., Weersma R.K., Fevery J., Mueller T., Chazouillères O., Schulze K., Schramm C., Almer S., Pereira S.P., Levy C., Mason A., Bowlus C.L., Floreani A., Halilbasic E., Trauner M., Yimam K.K., Milkiewicz P., Milkiewicz P., Huynh D.K., Pares A., Manser C.N., Dalekos G.N., Eksteen B., Invernizzi P., Berg C.P., Kirchner G.I., Sarrazin C., Zimmer V., Fabris L., Braun F., Marzioni M., Schramm C., Chapman R.W., Chapman R.W., Lindor K.D., Imam M., Lindor K.D., Naess S., Karlsen T.H., Schrumpf E., Boberg K.M., Hansen B.E., Hansen B.E., Hansen B.E., on behalf of the, International PSC Study Group (2017)
      Background & Aims Primary sclerosing cholangitis (PSC) is an orphan hepatobiliary disorder associated with inflammatory bowel disease (IBD). We aimed to estimate the risk of disease progression based on distinct clinical ...

    • PBC Screen: An IgG/IgA dual isotype ELISA detecting multiple mitochondrial and nuclear autoantibodies specific for primary biliary cirrhosis 

      Liu, H.; Norman, G. L.; Shums, Z.; Worman, H. J.; Krawitt, E. L.; Bizzaro, N.; Vergani, D.; Bogdanos, D. P.; Dalekos, G. N.; Milkiewicz, P.; Czaja, A. J.; Heathcote, E. J.; Hirschfield, G. M.; Tan, E. M.; Miyachi, K.; Bignotto, M.; Battezzati, P. M.; Lleo, A.; Leung, P. S.; Podda, M.; Gershwin, M. E.; Invernizzi, P. (2010)
      A dual isotype (IgG, IgA) enzyme-linked immunosorbent assay (ELISA) designed to provide enhanced detection of primary biliary cirrhosis (PBC)-specific autoantibodies against both major mitochondrial and nuclear antigens ...

    • Promyelocytic leukemia antigen expression: A histological marker for primary biliary cholangitis diagnosis? 

      Papamichalis P.A., Zachou K., Papamichali R.A., Ioannou M., Gatselis N.K., Dalekos G.N., Koukoulis G.K. (2021)
      Distinguishing primary biliary cholangitis (PBC) from other cholestatic diseases at the histological level could be assisted by new methods, such as immunohistochemical staining of specific antigens. We evaluated whether ...

    • The role of invariant NKT in autoimmune liver disease: Can Vitamin D Act as an Immunomodulator? 

      Smyk D.S., Mavropoulos A., Mieli-Vergani G., Vergani D., Lenzi M., Bogdanos D.P. (2018)
      Natural killer T (NKT) cells are a distinct lineage of T cells which express both the T cell receptor (TCR) and natural killer (NK) cell markers. Invariant NKT (iNKT) cells bear an invariant TCR and recognize a small variety ...

    • Second generation analysis of antinuclear antibody (ANA) by combination of screening and confirmatory testing 

      Scholz J., Grossmann K., Knütter I., Hiemann R., Sowa M., Röber N., Rödiger S., Schierack P., Reinhold D., Bogdanos D.P., Meroni P.L., Radice A., Conrad K., Roggenbuck D. (2015)
      Background: For the serological diagnosis of systemic autoimmune rheumatic diseases, a two-tier approach starting with sensitive antinuclear antibody (ANA) detection by indirect immunofluorescence (IIF) on HEp-2 cells ...

    • The second greek–israeli symposium on autoimmunity and rheumatology: Success through synergy 

      Sakkas L.I., Bogdanos D.P., Boumpas D., Mamouris Z., Gkoutzourelas A., Mavropoulos A., Tsouris Z., Liossis S.-N., Daoussis D., Vasilopoulos D., Tektonidou M., Tzioufas A., Efthymiou G., Dardiotis E., Kitas G., Sharif K., Blank M., Karussis D., Rimar D., Slobodin G., Porat-Katz B.-S., Vadasz Z., Amital H., Toubi E., Shoenfeld Y. (2019)
      [No abstract available]

    • Support of precision medicine through risk-stratification in autoimmune liver diseases – histology, scoring systems, and non-invasive markers 

      Bossen L., Gerussi A., Lygoura V., Mells G.F., Carbone M., Invernizzi P. (2018)
      Autoimmune liver diseases (AILDs) are complex conditions, which arise from the interaction between a genetic susceptibility and unknown environmental triggers. They represent a relevant cause of liver failure and liver ...