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Listar por tema "malignant neoplasm"

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    • 2020 international consensus on ANCA testing beyond systemic vasculitis 

      Moiseev S., Cohen Tervaert J.W., Arimura Y., Bogdanos D.P., Csernok E., Damoiseaux J., Ferrante M., Flores-Suárez L.F., Fritzler M.J., Invernizzi P., Jayne D., Jennette J.C., Little M.A., McAdoo S.P., Novikov P., Pusey C.D., Radice A., Salama A.D., Savige J.A., Segelmark M., Shoenfeld Y., Sinico R.A., Sousa M.-J., Specks U., Terrier B., Tzioufas A.G., Vermeire S., Zhao M.-H., Bossuyt X. (2020)
      This document follows up on a 2017 revised international consensus on anti-neutrophil cytoplasm antibodies (ANCA) testing in granulomatosis with polyangiitis and microscopic polyangiitis and focuses on the clinical and ...

    • 5G and human health 

      Theodorou K., Tyrakis C., Softa V., Kappas C. (2021)
      The considerable characteristics of 5G technology (Fifth Generation of telecommunication) is the very high amount of data that can be transmitted in the time unit (data speed: Megabits per second - throughput) and the very ...

    • Advancements in the Treatment of Cerebrovascular Complications of Cancer 

      Aloizou A.-M., Siokas V., Mentis A.-F.A., Dastamani M., Sokratous M., Xiromerisiou G., Mitsias P.D., Hadjigeorgiou G.M., Dardiotis E. (2020)
      Purpose of review: To present the new guidelines and therapeutic options regarding cerebrovascular complications of cancer, mainly ischemic stroke, cerebral venous thrombosis (CVT), and leptomeningeal carcinomatosis (LMC). ...

    • Anticancer and apoptosis-inducing effects of quercetin in vitro and in vivo 

      Hashemzaei M., Far A.D., Yari A., Heravi R.E., Tabrizian K., Taghdisi S.M., Sadegh S.E., Tsarouhas K., Kouretas D., Tzanakakis G., Nikitovic D., Anisimov N.Y., Spandidos D.A., Tsatsakis A.M., Rezaee R. (2017)
      The present study focused on the elucidation of the putative anticancer potential of quercetin. The anticancer activity of quercetin at 10, 20, 40, 80 and 120 μM was assessed in vitro by MMT assay in 9 tumor cell lines ...

    • Approaching reactive species in the frame of their clinical significance: A toxicological appraisal 

      Veskoukis A.S., Tsatsakis A., Kouretas D. (2020)
      Redox biology and toxicology are interrelated fields that have produced valuable evidence regarding the role and clinical significance of reactive species. These issues are analyzed herein by presenting 6 arguments, as ...

    • Cancer-associated stroke: Pathophysiology, detection and management (Review) 

      Dardiotis E., Aloizou A.-M., Markoula S., Siokas V., Tsarouhas K., Tzanakakis G., Libra M., Kyritsis A.P., Brotis A.G., Aschner M., Gozes I., Bogdanos D.P., Spandidos D.A., Mitsias P.D., Tsatsakis A. (2019)
      Numerous types of cancer have been shown to be associated with either ischemic or hemorrhagic stroke. In this review, the epidemiology and pathophysiology of stroke in cancer patients is discussed, while providing vital ...

    • Causes and Risk Factors of Cerebral Ischemic Events in Patients with Atrial Fibrillation Treated with Non-Vitamin K Antagonist Oral Anticoagulants for Stroke Prevention: The RENo Study 

      Paciaroni M., Agnelli G., Caso V., Silvestrelli G., Seiffge D.J., Engelter S., De Marchis G.M., Polymeris A., Zedde M.L., Yaghi S., Michel P., Eskandari A., Antonenko K., Sohn S.-I., Cappellari M., Tassinari T., Tassi R., Masotti L., Katsanos A.H., Giannopoulos S., Acciarresi M., Alberti A., Venti M., Mosconi M.G., Vedovati M.C., Pierini P., Giustozzi M., Lotti E.M., Ntaios G., Kargiotis O., Monaco S., Lochner P., Bandini F., Liantinioti C., Palaiodimou L., Abdul-Rahim A.H., Lees K., Mancuso M., Pantoni L., Rosa S., Bertora P., Galliazzo S., Ageno W., Toso E., Angelini F., Chiti A., Orlandi G., Denti L., Flomin Y., Marcheselli S., Mumoli N., Rimoldi A., Verrengia E., Schirinzi E., Del Sette M., Papamichalis P., Komnos A., Popovic N., Zarkov M., Rocco A., Diomedi M., Giorli E., Ciccone A., Grory B.C.M., Furie K.L., Bonetti B., Saia V., Guideri F., Acampa M., Martini G., Grifoni E., Padroni M., Karagkiozi E., Perlepe K., Makaritsis K., Mannino M., MacCarrone M., Ulivi L., Giannini N., Ferrari E., Pezzini A., Doronin B., Volodina V., Baldi A., D'Amore C., Deleu D., Corea F., Putaala J., Santalucia P., Nardi K., Risitano A., Toni D., Tsivgoulis G. (2019)
      Background and Purpose-Despite treatment with oral anticoagulants, patients with nonvalvular atrial fibrillation (AF) may experience ischemic cerebrovascular events. The aims of this case-control study in patients with AF ...

    • CD90/Thy-1, a cancer-associated cell surface signaling molecule 

      Sauzay C., Voutetakis K., Chatziioannou A.A., Chevet E., Avril T. (2019)
      CD90 is a membrane GPI-anchored protein with one Ig V-type superfamily domain that was initially described in mouse T cells. Besides the specific expression pattern and functions of CD90 that were described in normal tissues ...

    • Characterization of Patients with Embolic Strokes of Undetermined Source in the NAVIGATE ESUS Randomized Trial 

      Kasner S.E., Lavados P., Sharma M., Wang Y., Wang Y., Dávalos A., Shamalov N., Cunha L., Lindgren A., Mikulik R., Arauz A., Lang W., Czlonkowska A., Eckstein J., Gagliardi R., Amarenco P., Ameriso S.F., Tatlisumak T., Veltkamp R., Hankey G.J., Toni D.S., Bereczki D., Uchiyama S., Ntaios G., Yoon B.-W., Brouns R., DeVries Basson M.M., Endres M., Muir K., Bornstein N., Ozturk S., O'Donnell M., Mundl H., Pater C., Weitz J., Peacock W.F., Swaminathan B., Kirsch B., Berkowitz S.D., Peters G., Pare G., Themeles E., Shoamanesh A., Connolly S.J., Hart R.G., NAVIGATE ESUS Steering Committee and Investigators (2018)
      Background: The New Approach Rivaroxaban Inhibition of Factor Xa in a Global Trial vs. ASA to Prevent Embolism in Embolic Stroke of Undetermined Source (NAVIGATE-ESUS) trial is a randomized phase-III trial comparing ...

    • Climate change as a social determinant of the quality of public health 

      Tzavella F., Vgenopoulou I., Fradelos E.C. (2021)
      In recent years, it has become recognized worldwide that the threats and consequences of climate change for public health and, thus, for the quality of human life, are very serious. The need to protect the planet from ...

    • Coexisting morbidity burden in elderly hospitalized patients with and without heart failure 

      Simou A., Xanthopoulos A., Giamouzis G., Papagiannis D., Dimos A., Economou D., Skoularigis J., Triposkiadis F. (2022)
      Introduction: Aging, cardiovascular disease (CVD), and heart failure (HF) increase the coexisting morbidity (CM) burden. This study compared the contribution of HF with this increase in elderly patients hospitalized for ...

    • Current and future aspects of TIM-3 as biomarker or as potential targeted in non-small cell lung cancer scope: Is there a role in clinical practice? 

      de Mello R.A., Zhu J.-H., Iavelberg J., Potim A.H., Simonetti D., Júnior J.A.S., Castelo-Branco P., Pozza D.H., Tajima C.C., Tolia M., Antoniou G. (2020)
      [No abstract available]

    • Data-driven machine-learning analysis of potential embolic sources in embolic stroke of undetermined source 

      Ntaios G., Weng S.F., Perlepe K., Akyea R., Condon L., Lambrou D., Sirimarco G., Strambo D., Eskandari A., Karagkiozi E., Vemmou A., Korompoki E., Manios E., Makaritsis K., Vemmos K., Michel P. (2021)
      Background and purpose: Hierarchical clustering, a common ‘unsupervised’ machine-learning algorithm, is advantageous for exploring potential underlying aetiology in particularly heterogeneous diseases. We investigated ...

    • Determinants of refugee and migrant health status in 10 european countries: The mig-healthcare project 

      Riza E., Karnaki P., Gil-Salmerón A., Zota K., Ho M., Petropoulou M., Katsas K., Garcés-Ferrer J., Linos A. (2020)
      In this study, we collect and synthesize information on the health status of the refugee/migrant population in ten European countries in order to map refugee/migrant health needs. With this information, we identify areas ...

    • Diabetes on sepsis outcomes in non-ICU patients: A cohort study and review of the literature 

      Akinosoglou K., Kapsokosta G., Mouktaroudi M., Rovina N., Kaldis V., Stefos A., Kontogiorgi M., Giamarellos-Bourboulis E., Gogos C., Hellenic Sepsis Study Group (2021)
      Aims: We sought to determine whether primary outcomes differ between non-ICU septic patients with and without type 2 diabetes (T2D). Methods: This study utilized the Hellenic Sepsis Study Group Registry, collecting nationwide ...

    • Do the Kinetics of Antibody Responses Predict Clinical Outcome in Hospitalized Patients With Moderate-to-Severe COVID-19? 

      Pavlidis G., Kampolis C.F., Perlepe G., Pagonis A., Maniotis C., Koullias E., Kranidioti H., Kyritsis A., Pavlou E., Sinis S., Pirounaki M., Vassilopoulos D., Gourgoulianis K., Pantazopoulos I. (2022)
      Background/Aim: The relationship between the kinetics of antibody responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the severity of Coronavirus Disease 2019 (COVID-19) is poorly understood. The ...

    • Editorial: Role of Ribonucleases in Immune Response Regulation During Infection and Cancer 

      Boix E., Acquati F., Leonidas D., Pulido D. (2020)
      [No abstract available]

    • ERK signaling controls productive HIF-1 binding to chromatin and cancer cell adaptation to hypoxia through HIF-1α interaction with NPM1 

      Koukoulas K., Giakountis A., Karagiota A., Samiotaki M., Panayotou G., Simos G., Mylonis I. (2021)
      The hypoxia-inducible factor HIF-1 is essential for oxygen homeostasis. Despite its well-understood oxygen-dependent expression, regulation of its transcriptional activity remains unclear. We show that phosphorylation by ...

    • Factors Associated With Noninfectious Fever After Endovascular Aortic Aneurysm Repair 

      Nana P., Spanos K., Dakis K., Karathanos C., Kouvelos G., Giannoukas A. (2022)
      Purpose: The post–endovascular abdominal aortic aneurysm repair (EVAR) inflammatory response, which is very often associated with fever, has been ascribed to a wide range of proinflammatory mediators and operative events. ...

    • Haplotype structure defines effects of common DPYD variants c.85T > C (rs1801265) and c.496A > G (rs2297595) on dihydropyrimidine dehydrogenase activity: Implication for 5-fluorouracil toxicity 

      Hamzic S., Schärer D., Offer S.M., Meulendijks D., Nakas C., Diasio R.B., Fontana S., Wehrli M., Schürch S., Amstutz U., Largiadèr C.R. (2021)
      Aims: The aim of this study was to identify risk variants and haplotypes that impair dihydropyrimidine dehydrogenase (DPD) activity and are, therefore, candidate risk variants for severe toxicity to 5-fluorouracil (5-FU) ...