Πλοήγηση ανά Θέμα "lymphocyte activation"

Acquisition of optimal TFH cell function is defined by specific molecular, positional, and TCR dynamic signatures

Padhan K., Moysi E., Noto A., Chassiakos A., Ghneim K., Perra M.M., Shah S., Papaioannou V., Fabozzi G., Ambrozak D.R., Poultsidi A., Ioannou M., Fenwick C., Darko S., Douek D.C., Sekaly R.-P., Pantaleo G., Koup R.A., Petrovas C. (2021)

The development of follicular helper CD4 T (TFH) cells is a dynamic process resulting in a heterogenous pool of TFH subsets. However, the cellular and molecular determinants of this heterogeneity and the possible mechanistic ...

Breg Cells Are Numerically Decreased and Functionally Impaired in Patients with Systemic Sclerosis

Mavropoulos A., Simopoulou T., Varna A., Liaskos C., Katsiari C.G., Bogdanos D.P., Sakkas L.I. (2016)

Objective Breg cells, a regulatory cell subset that produces interleukin-10 (IL-10), play a significant role in suppressing autoimmune responses and preventing autoimmunity. This study was undertaken to examine the number ...

Crystalline silica activates the T-cell and the B-cell antigen receptor complexes and induces T-cell and B-cell proliferation

Eleftheriadis T., Pissas G., Zarogiannis S., Liakopoulos V., Stefanidis I. (2019)

Silicosis is an occupational fibrotic lung disease, which is associated with an increased incidence of autoimmune diseases. The effect of crystalline silica on the immune system is thought to be mediated by the antigen ...

Differential effects of the two amino acid sensing systems, the GCN2 kinase and the mTOR complex 1, on primary human alloreactive CD4+ T-cells

Eleftheriadis T., Pissas G., Antoniadi G., Liakopoulos V., Tsogka K., Sounidaki M., Stefanidis I. (2016)

Amino acid deprivation activates general control nonderepressible 2 (GCN2) kinase and inhibits mammalian target of rapamycin (mTOR), affecting the immune response. In this study, the effects of GCN2 kinase activation or ...

In Mixed Lymphocyte Reaction, the Hypoxia-Inducible Factor Prolyl-Hydroxylase Inhibitor Roxadustat Suppresses Cellular and Humoral Alloimmunity

Eleftheriadis T., Pissas G., Mavropoulos A., Nikolaou E., Filippidis G., Liakopoulos V., Stefanidis I. (2020)

Hypoxia-inducible factor (HIF) prolyl-hydroxylase inhibitors are currently used for the treatment of renal anemia. Since HIF affects immune cells, we evaluated the effect of such a drug, the roxadustat, on adaptive immunity. ...

Indoleamine 2,3-dioxygenase, by degrading L-tryptophan, enhances carnitine palmitoyltransferase i activity and fatty acid oxidation, and exerts fatty acid-dependent effects in human alloreactive CD4+ T-cells

Eleftheriadis T., Pissas G., Sounidaki M., Tsogka K., Antoniadis N., Antoniadi G., Liakopoulos V., Stefanidis I. (2016)

Indoleamine 2,3-dioxygenase (IDO) is expressed in antigen presenting cells and by degrading L-tryptophan along the kynurenine pathway suppresses CD4+ T-cell proliferation, induces apoptosis and promotes differentiation ...

Interleukin 21 controls mRNAand MicroRNA expression in CD40-activated chronic lymphocytic leukemia cells

De Cecco L., Capaia M., Zupo S., Cutrona G., Matis S., Brizzolara A., Orengo A.M., Croce M., Marchesi E., Ferrarini M., Canevari S., Ferrini S., Speletas M. (2015)

Several factors support CLL cell survival in the microenvironment. Under different experimental conditions, IL21 can either induce apoptosis or promote CLL cell survival. To investigate mechanisms involved in the effects ...

Persistent Activation of Innate Immunity in Patients with Primary Antibody Deficiencies

Tsinti G., Makris D., Germenis A.E., Speletas M. (2020)

Primary antibody deficiencies (PAD) represent a heterogeneous group of disorders, with common variable immunodeficiency being the most common with clinical significance. The main phenotypic defect resides in the inability ...

A role for human renal tubular epithelial cells in direct allo-recognition by CD4+ T-cells and the effect of ischemia-reperfusion

Eleftheriadis T., Pissas G., Crespo M., Nikolaou E., Liakopoulos V., Stefanidis I. (2021)

Direct allorecognition is the earliest and most potent immune response against a kidney allograft. Currently, it is thought that passenger donor professional antigen-presenting cells (APCs) are responsible. Further, many ...

Systemic sclerosis: New evidence re-enforces the role of B cells

Sakkas L.I., Bogdanos D.P. (2016)

Systemic sclerosis (SSc) is characterized by widespread fibrosis, microangiopathy (vasospasms and stenosis), and formation of autoantibodies. T cell activation has been shown to contribute to fibrosis and microvasculopathy ...

The transcription factor BCL-6 controls early development of innate-like T cells

Gioulbasani M., Galaras A., Grammenoudi S., Moulos P., Dent A.L., Sigvardsson M., Hatzis P., Kee B.L., Verykokakis M. (2020)

Innate T cells, including invariant natural killer T (iNKT) and mucosal-associated innate T (MAIT) cells, are a heterogeneous T lymphocyte population with effector properties preprogrammed during their thymic differentiation. ...

Transcriptome Analysis Identifies Immune Markers Related to Visceral Leishmaniasis Establishment in the Experimental Model of BALB/c Mice

Agallou M., Athanasiou E., Kammona O., Tastsoglou S., Hatzigeorgiou A.G., Kiparissides C., Karagouni E. (2019)

Visceral leishmaniasis (VL) caused by Leishmania donovani and L. infantum is a potentially fatal disease. To date there are no registered vaccines for disease prevention despite the fact that several vaccines are in ...