Parcourir par sujet "interleukin 8"

Activation of general control nonderepressible-2 kinase ameliorates glucotoxicity in human peritoneal mesothelial cells, preserves their integrity, and prevents mesothelial to mesenchymal transition

Eleftheriadis T., Pissas G., Antoniadi G., Nikolaou E., Golfinopoulos S., Liakopoulos V., Stefanidis I. (2019)

Along with infections, ultrafiltration failure due to the toxicity of glucose-containing peritoneal dialysis (PD) solutions is the Achilles’ heel of PD method. Triggered by the protective effect of general control ...

Gene Expression Meta-Analysis of Potential Shared and Unique Pathways between Autoimmune Diseases under Anti-TNFα Therapy

Antonatos C., Panoutsopoulou M., Georgakilas G.K., Evangelou E., Vasilopoulos Y. (2022)

While anti-TNFα has been established as an effective therapeutic approach for several autoimmune diseases, results from clinical trials have uncovered heterogeneous patients’ response to therapy. Here, we conducted a ...

The genetic map of diabetic nephropathy: Evidence from a systematic review and meta-analysis of genetic association studies

Tziastoudi M., Stefanidis I., Zintzaras E. (2020)

Despite the extensive efforts of scientists, the genetic background of diabetic nephropathy (DN) has not yet been clarified. To elucidate the genetic variants that predispose to the development of DN, we conducted a ...

Incorporating Biomarkers in COPD Management: The Research Keeps Going

Pantazopoulos I., Magounaki K., Kotsiou O., Rouka E., Perlikos F., Kakavas S., Gourgoulianis K. (2022)

Globally, chronic obstructive pulmonary disease (COPD) remains a major cause of morbidity and mortality, having a significant socioeconomic effect. Several molecular mechanisms have been related to COPD including chronic ...

Individualized significance of the −251 A/T single nucleotide polymorphism of interleukin-8 in severe infections

Georgitsi M.D., Vitoros V., Panou C., Tsangaris I., Aimoniotou E., Gatselis N.K., Chasou E., Kouliatsis G., Leventogiannis K., Velissaris D., Belesiotou E., Dioritou-Aggaliadou O., Giannitsioti E., Netea M.G., Giamarellos-Bourboulis E.J., Giannikopoulos G., Alexiou Z., Voloudakis N., Koutsoukou A. (2016)

Based on the concept of the individualized nature of sepsis, we investigated the significance of the −251 A/T (rs4073) single nucleotide polymorphism (SNP) of interleukin (IL)-8 in relation to the underlying infection. ...

Links between HPA axis and adipokines: clinical implications in paradigms of stress-related disorders

Papargyri P., Zapanti E., Salakos N., Papargyris L., Bargiota A., Mastorakos G. (2018)

Introduction: In the human organism, a constant interplay exists between the stress system [which includes the activity of the hypothalamic-pituitary-adrenal (HPA) axis] and the adipose tissue. This interplay is mediated ...

Mammary defences and immunity against mastitis in sheep

Katsafadou A.I., Politis A.P., Mavrogianni V.S., Barbagianni M.S., Vasileiou N.G.C., Fthenakis G.C., Fragkou I.A. (2019)

The objectives of this review paper are to present udder defences, including teat of the udder, mammary epithelial cells, leucocytes, immunoglobulins, complement systemand chemical antibacterial agents, to describe cooperation ...

Smoke and autoimmunity: The fire behind the disease

Perricone C., Versini M., Ben-Ami D., Gertel S., Watad A., Segel M.J., Ceccarelli F., Conti F., Cantarini L., Bogdanos D.P., Antonelli A., Amital H., Valesini G., Shoenfeld Y. (2016)

The association between smoke habit and autoimmunity has been hypothesized a long time ago. Smoke has been found to play a pathogenic role in certain autoimmune disease as it may trigger the development of autoantibodies ...

A systematic review and meta-analysis of genetic association studies for the role of inflammation and the immune system in diabetic nephropathy

Tziastoudi M., Stefanidis I., Hadjigeorgiou G.M., Stravodimos K., Zintzaras E. (2017)

Background: Despite the certain contribution of metabolic and haemodynamic factors in diabetic nephropathy (DN), many lines of evidence highlight the role of immunologic and inflammatory mechanisms. To elucidate the ...

Systemic sclerosis: New evidence re-enforces the role of B cells

Sakkas L.I., Bogdanos D.P. (2016)

Systemic sclerosis (SSc) is characterized by widespread fibrosis, microangiopathy (vasospasms and stenosis), and formation of autoantibodies. T cell activation has been shown to contribute to fibrosis and microvasculopathy ...

Transcriptomic analysis of the claudin interactome in malignant pleural mesothelioma: Evaluation of the effect of disease phenotype, asbestos exposure, and CDKN2A deletion status

Rouka E., Vavougios G.D., Solenov E.I., Gourgoulianis K.I., Hatzoglou C., Zarogiannis S.G. (2017)

Malignant pleural mesothelioma (MPM) is a highly aggressive tumor primarily associated with asbestos exposure. Early detection of MPM is restricted by the long latency period until clinical presentation, the ineffectiveness ...

A unifying model of glucotoxicity in human renal proximal tubular epithelial cells and the effect of the SGLT2 inhibitor dapagliflozin

Eleftheriadis T., Pissas G., Tsogka K., Nikolaou E., Liakopoulos V., Stefanidis I. (2020)

Background: Glucotoxicity in renal tubular epithelial cells (RPTECs) contributes to the pathogenesis of diabetic nephropathy. Sodium-glucose cotransporter 2 (SGLT2) inhibitors may exert their renoprotective effect by ...