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    • Acinetobacter baumannii antibiotic resistance mechanisms 

      Kyriakidis I., Vasileiou E., Pana Z.D., Tragiannidis A. (2021)
      Acinetobacter baumannii is a Gram-negative ESKAPE microorganism that poses a threat to public health by causing severe and invasive (mostly nosocomial) infections linked with high mortality rates. During the last years, ...

    • Antimicrobial resistance genes in ESBL-producing escherichia coli isolates from animals in Greece 

      Athanasakopoulou Z., Reinicke M., Diezel C., Sofia M., Chatzopoulos D.C., Braun S.D., Reissig A., Spyrou V., Monecke S., Ehricht R., Tsilipounidaki K., Giannakopoulos A., Petinaki E., Billinis C. (2021)
      The prevalence of multidrug resistant, extended spectrum -lactamase (ESBL)-producing Enterobacteriaceae is increasing worldwide. The present study aimed to provide an overview of the multidrug resistance phenotype and ...

    • Geographical variation in therapy for bloodstream infections due to multidrug-resistant Enterobacteriaceae: a post-hoc analysis of the INCREMENT study 

      Harris P.N.A., Pezzani M.D., Gutiérrez-Gutiérrez B., Viale P., Hsueh P.-R., Ruiz-Garbajosa P., Venditti M., Tumbarello M., Navarro-Francisco C., Calbo E., Akova M., Giamarellou H., Oliver A., Almirante B., Gasch O., Martínez-Martínez L., Schwaber M.J., Daikos G., Pitout J., Peña C., Hernández-Torres A., Doi Y., Pérez F., Tuon F.F., Tacconelli E., Carmeli Y., Bonomo R.A., Pascual Á., Paterson D.L., Rodríguez-Baño J., del Toro M.D., Gálvez J., Falcone M., Russo A., Karaiskos I., Trecarichi E.M., Losito A.R., García-Vázquez E., Gómez J., Roilides E., Iosifidis E., Pournaras S., Prim N., Navarro F., Mirelis B., Origüen J., Juan R.S., Fernández-Ruiz M., Almela M., de la Calle C., Martínez J.A., Morata L., Larrosa N., Puig-Asensio M., Bou G., Molina J., González V., Bermejo J., Rucci V., de Gopegui E.R., Marinescu C.I., Fariñas M.C., Cano M.E., Gozalo M., Paño-Pardo J.R., Mora-Rillo M., Gómez-Zorrilla S., Tubau F., Tsakris A., Zarkotou O., Antoniadou A., Poulakou G., Souli M., Lowman W., Virmani D., Torre-Cisneros J., Machuca I., Gracia-Ahufinger I., Azap Ö.K., Helvaci Ö., Sahin A.O., Cantón R., Pintado V., Bartoletti M., Giannella M., Peter S., Hamprecht A., Badia C., Xercavins M., Fontanals D., Jové E., ESGBIS/REIPI/INCREMENT Group (2017)
      We describe regional differences in therapy for bloodstream infection (BSI) caused by extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-E) or carbapenemase-producing Enterobacteriaceae (CPE). Patients (n = ...

    • Lack of synergistic nephrotoxicity between vancomycin and piperacillin/tazobactam in a rat model and a confirmatory cellular model 

      Pais G.M., Liu J., Avedissian S.N., Hiner D., Xanthos T., Chalkias A., D'Aloja E., Locci E., Gilchrist A., Prozialeck W.C., Rhodes N.J., Lodise T.P., Fitzgerald J.C., Downes K.J., Zuppa A.F., Scheetz M.H. (2020)
      Vancomycin and piperacillin/tazobactam are reported in clinical studies to increase acute kidney injury (AKI). However, no clinical study has demonstrated synergistic toxicity, only that serum creatinine increases. To ...

    • Novel molecular techniques for the identification of the members of Brucellaceae family 

      Papaventsis, D.; Siafakas, N.; Markoulatos, P.; Sopidou, V.; Economou, C.; Levidiotou-Stefanou, S. (2006)
      An account is presented of an attempt to identify a multiresistant, gram-negative bacterium that was isolated from raw sewage in Cyprus. The API 2ONE system was initially used to identify the strain on the basis of its ...

    • Predominance of international clone 2 OXA-23-producing-Acinetobacter baumannii clinical isolates in Greece, 2015: results of a nationwide study 

      Pournaras S., Dafopoulou K., Del Franco M., Zarkotou O., Dimitroulia E., Protonotariou E., Poulou A., Zarrilli R., Tsakris A., Skoura L., Themeli-Digalaki K., Perivolioti E., Tsiplakou S., Karavassilis V., Panopoulou M., Orfanidou M., Hadjichristodoulou C., Levidiotou S., Gikas A., Greek Study Group on Acinetobacter Antimicrobial Resistance (2017)
      In a previous nationwide study in Greece, OXA-58 was the sole carbapenemase present among carbapenem-resistant Acinetobacter baumannii (CRAB) isolated between 2000 and 2009. In this study, the antibiotic resistances, ...

    • Survival benefit associated with clarithromycin in severe community-acquired pneumonia: A matched comparator study 

      Kyriazopoulou E., Sinapidis D., Halvatzis S., Velissaris D., Alexiou N., Kosmas V., Adami M.-E., Kyprianou M., Kyprianou A., Stefos A., Lada M., Koutoukas P., Pavlaki M., Kyriakoudi A., Makina A., Gogos C., Niederman M.S., Giamarellos-Bourboulis E.J. (2020)
      Although analysis of retrospective studies has documented survival benefit from the addition of a macrolide to the treatment regimen for community-acquired pneumonia (CAP), no data are available to determine if there is ...

    • VIM-1 metallo-β-lactamase in Acinetobacter baumannii 

      Tsakris, A.; Ikonomidis, A.; Pournaras, S.; Tzouvelekis, L. S.; Sofianou, D.; Legakis, N. J.; Maniatis, A. N. (2006)
      In 2004 and 2005, 5 metallo-β-lactamase (MBL)-positive Acinetobacter baumannii isolates were found in 2 Greek hospitals. Isolates were unrelated and carried blaVIM-1 in a class 1 integron; blaOXA-51- and blaOXA-58-like ...

    • VIM-12, a novel plasmid-mediated metallo-β-lactamase from Klebsiella pneumoniae that resembles a VIM-1/VIM-2 hybrid 

      Pournaras, S.; Ikonomidis, A.; Tzouvelekis, L. S.; Tokatlidou, D.; Spanakis, N.; Maniatis, A. N.; Legakis, N. J.; Tsakris, A. (2005)
      A transferable plasmid from Klebsiella pneumoniae carried a class 1 integron containing blaVIM-12, a novel blaVIM-type gene, flanked by two copies of aacA7. blaVIM-12 was clustered between bla-VIM-1 and bla-VIM-2 and ...