• Addressing the post-irradiation hypothalamic-pituitary endocrine abnormalities of brain tumors in pediatric patients 

      Velentza L., Tolia M., Christakou C., Nikolaou M., Zerdes I.-N., Tsoukalas N., Hajiioannou J., Tsanadis K., Rigas G., Mitsis M., Theodorou K., Pistevou-Gombaki K., Tsekeris P., Kyrgias G. (2017)
      Purpose: Hypothalamic-pituitary axis is susceptible to radiotherapy, causing endocrine disorders to childhood cancer survivors. We conducted a systematic review in order to assess the radiation-induced toxicity that leads ...
    • Benign intracranial lesions-radiotherapy: An overview of treatment options, indications and therapeutic results 

      Tzikoulis V., Gkantaifi A., Alongi F., Tsoukalas N., Saraireh H.H., Charalampakis N., Tzikoulis G., Andreou E., Tsapakidis K., Kardamakis D., Tsanadis K., Kyrgias G., Tolia M. (2020)
      Background: Radiation Therapy (RT) is an established treatment option for benign intracranial lesions. The aim of this study is to display an update on the role of RT concerning the most frequent benign brain lesions and ...
    • Combined anterior and posterior shoulder dislocation as a manifestation of a brain tumour 

      Tsionos, I.; Karahalios, T.; Zibis, A. H.; Malizos, K. N. (2004)
      Seizures are sometimes the first manifestation of a brain tumour. They may give rise to shoulder fractures or fracture-dislocations. When bilateral, these lesions tend to be symmetrical. The patient reported here suffered ...
    • COVID-19 among children with cancer in Greece (2020): Results from the Nationwide Registry of Childhood Hematological Malignancies and Solid Tumors (NARECHEM-ST) 

      Baka M., Michos A., Alexopoulou A., Bouka P., Bouka E., Dana E., Dimitriou G., Doganis, Grivea I., Ioannidou M., Kourti M., Magkou E., Makis A., Malama A., Mantadakis E., Markozannes G., Mitsios A., Moschovi M., Papadakis V., Panagopoulou P., Papakonstantinou E., Papadopoulos S., Polychronopoulou S., Themistocleous M., Tzotzola V., Ntzani E., Petridou E.T. (2021)
      [No abstract available]
    • Dual IRE1 RNase functions dictate glioblastoma development 

      Lhomond S., Avril T., Dejeans N., Voutetakis K., Doultsinos D., McMahon M., Pineau R., Obacz J., Papadodima O., Jouan F., Bourien H., Logotheti M., Jégou G., Pallares-Lupon N., Schmit K., Le Reste P.-J., Etcheverry A., Mosser J., Barroso K., Vauléon E., Maurel M., Samali A., Patterson J.B., Pluquet O., Hetz C., Quillien V., Chatziioannou A., Chevet E. (2018)
      Proteostasis imbalance is emerging as a major hallmark of cancer, driving tumor aggressiveness. Evidence suggests that the endoplasmic reticulum (ER), a major site for protein folding and quality control, plays a critical ...
    • Effect of single dose irradiation on human glioblastoma spheroids in vitro 

      Fehlauer, F.; Stalpers, L. J. A.; Panayiotides, J.; Kaaijk, P.; González Gonźalez, D.; Leenstra, S.; Van Der Valk, P.; Sminia, P. (2004)
      Investigation of the predictive value of a radiosurgery-relevant treatment of glioblastoma spheroids. Organotypic multicellular spheroids were cultured and irradiated (20 Gy). Morphology, apoptosis and immunohistochemical ...
    • Focus on the use of resveratrol as an adjuvant in glioblastoma therapy 

      Dionigi L., Ragonese F., Monarca L., Covino S., de Luca A., Iannitti R.G., Bastioli F., Moulas A.N., Allegretti M., Fioretti B. (2020)
      Glioblastoma (GB) represents the most common and malignant form of glioma cancer. The Gold Standard in Glioblastoma is neurosurgical tumor removal and radiotherapy treatment in concomitant with temo-zolomide (TMZ). ...
    • Glioblastoma Multiforme in a Patient with Celiac Disease: Management of Seizures After Gross Total Tumor Resection 

      Fotakopoulos G., Brotis A.G., Kotlia P., Fountas K. (2018)
      Background: A 55-year-old woman with a history of celiac disease presented with focal seizures and a mass lesion located at the left frontal lobe. Management of seizures in these patients is challenging. Case Description: ...
    • Imaging biomarker analysis of advanced multiparametric MRI for glioma grading 

      Vamvakas A., Williams S.C., Theodorou K., Kapsalaki E., Fountas K., Kappas C., Vassiou K., Tsougos I. (2019)
      Aims and objectives: To investigate the value of advanced multiparametric MR imaging biomarker analysis based on radiomic features and machine learning classification, in the non-invasive evaluation of tumor heterogeneity ...
    • Lapatinib with whole brain radiotherapy in patients with brain metastases from breast and non-small cell lung cancer: a phase II study of the Hellenic Cooperative Oncology Group (HeCOG) 

      Christodoulou C., Kalogera-Fountzila A., Karavasilis V., Kouvatseas G., Papandreou C.N., Samantas E., Varaki K., Papadopoulos G., Bobos M., Rallis G., Razis E., Goudopoulou A., Kalogeras K.T., Syrigos K.N., Fountzilas G. (2017)
      Small molecules, mainly tyrosine kinase inhibitors, are currently used in various malignancies. Lapatinib, a dual inhibitor of EGFR/HER2 tyrosine kinases, has demonstrated effectiveness in brain metastases from HER2-overexpressing ...
    • Local intracerebral inhibition of IRE1 by MKC8866 sensitizes glioblastoma to irradiation/chemotherapy in vivo 

      Le Reste P.J., Pineau R., Voutetakis K., Samal J., Jégou G., Lhomond S., Gorman A.M., Samali A., Patterson J.B., Zeng Q., Pandit A., Aubry M., Soriano N., Etcheverry A., Chatziioannou A., Mosser J., Avril T., Chevet E. (2020)
      Glioblastoma multiforme (GBM) is the most severe primary brain cancer. Despite an aggressive treatment comprising surgical resection and radio/chemotherapy, patient's survival post diagnosis remains short. A limitation for ...
    • Machine learning assisted DSC-MRI radiomics as a tool for glioma classification by grade and mutation status 

      Sudre C.H., Panovska-Griffiths J., Sanverdi E., Brandner S., Katsaros V.K., Stranjalis G., Pizzini F.B., Ghimenton C., Surlan-Popovic K., Avsenik J., Spampinato M.V., Nigro M., Chatterjee A.R., Attye A., Grand S., Krainik A., Anzalone N., Conte G.M., Romeo V., Ugga L., Elefante A., Ciceri E.F., Guadagno E., Kapsalaki E., Roettger D., Gonzalez J., Boutelier T., Cardoso M.J., Bisdas S. (2020)
      Background: Combining MRI techniques with machine learning methodology is rapidly gaining attention as a promising method for staging of brain gliomas. This study assesses the diagnostic value of such a framework applied ...
    • Multimodality-multiparametric brain tumors evaluation 

      Tsitsia V., Svolou P., Kapsalaki E., Theodorou K., Vassiou K., Valotassiou V., Georgoulias P., Fezoulidis I., Tsougos I. (2017)
      Brain tumors represent a vast group of lesions, originating from different neuronal cells with different degrees of aggressiveness. Despite some technological advances either pre or post-treatment, these tumors may share ...
    • Proposed definition of competencies for surgical neuro-oncology training 

      Kamp M.A., Malzkorn B., von Sass C., DiMeco F., Hadjipanayis C.G., Senft C., Rapp M., Gepfner-Tuma I., Fountas K., Krieg S.M., Neukirchen M., Florian I.Ș., Schnell O., Mijderwijk H.-J., Perin A., Baumgarten P., van Lieshout J.H., Thon N., Renovanz M., Kahlert U., Spoor J.K.H., Hänggi D., McLean A.L., Mäurer M., Sarrubbo S., Freyschlag C.F., Schmidt N.O., Vergani F., Jungk C., Stein M., Forster M.-T., Weinberg J.S., Sinclair J., Belykh E., Bello L., Mandonnet E., Moiyadi A., Sabel M. (2021)
      Objective: The aim of this work is to define competencies and entrustable professional activities (EPAs) to be imparted within the framework of surgical neuro-oncological residency and fellowship training as well as the ...
    • The role of MiRNA-21 in gliomas: Hope for a novel therapeutic intervention? 

      Aloizou A.-M., Pateraki G., Siokas V., Mentis A.-F.A., Liampas I., Lazopoulos G., Kovatsi L., Mitsias P.D., Bogdanos D.P., Paterakis K., Dardiotis E. (2020)
      Gliomas are the most common primary brain tumors in adults. They are generally very resistant to treatment and are therefore associated with negative outcomes. MicroRNAs (miRNAs) are small, non-coding RNA molecules that ...
    • Tumor-treating fields as a fourth treating modality for glioblastoma: a meta-analysis 

      Magouliotis D.E., Asprodini E.K., Svokos K.A., Tasiopoulou V.S., Svokos A.A., Toms S.A. (2018)
      Background: We aim to review the available literature on patients suffering from glioblastoma treated with tumor-treating fields (TTFields) plus radio chemotherapy or conventional radio chemotherapy alone, to compare the ...