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Πλοήγηση ανά Θέμα "biological model"

Αποτελέσματα 1-20 από 46

    • The -938C>A polymorphism in MYD88 is associated with susceptibility to tuberculosis: A pilot study 

      Aggelou K., Siapati E.K., Gerogianni I., Daniil Z., Gourgoulianis K., Ntanos I., Simantirakis E., Zintzaras E., Mollaki V., Vassilopoulos G. (2016)
      Introduction. Tuberculosis (TB) is a major disease worldwide, caused by Mycobacterium tuberculosis (MTB) infection.The Toll- Like Receptor (TLR) pathway plays a crucial role in the recognition of MTB. Aim. The present study ...

    • BDNF rs6265 (Val66Met) Polymorphism as a Risk Factor for Blepharospasm 

      Siokas V., Kardaras D., Aloizou A.-M., Asproudis I., Boboridis K.G., Papageorgiou E., Hadjigeorgiou G.M., Tsironi E.E., Dardiotis E. (2019)
      A few genetic variants are implicated in the development of blepharospasm (BSP). The precise role of the rs6265 on the brain-derived neurotrophic factor (BDNF) gene on BSP remains controversial. The effect of rs6265 on BSP ...

    • Bipartite graphs in systems biology and medicine: A survey of methods and applications 

      Pavlopoulos G.A., Kontou P.I., Pavlopoulou A., Bouyioukos C., Markou E., Bagos P.G. (2018)
      The latest advances in high-throughput techniques during the past decade allowed the systems biology field to expand significantly. Today, the focus of biologists has shifted from the study of individual biological components ...

    • Calcitriol Suppresses HIF-1 and HIF-2 Transcriptional Activity by Reducing HIF-1/2α Protein Levels via a VDR-Independent Mechanism 

      Gkotinakou I.-M., Kechagia E., Pazaitou-Panayiotou K., Mylonis I., Liakos P., Tsakalof A. (2020)
      Hypoxia-inducible transcription factors 1 and 2 (HIFs) are major mediators of cancer development and progression and validated targets for cancer therapy. Although calcitriol, the biologically active metabolite of vitamin ...

    • CD33 rs3865444 as a risk factor for Parkinson's disease 

      Siokas V., Arseniou S., Aloizou A.-M., Tsouris Z., Liampas I., Sgantzos M., Liakos P., Bogdanos D.P., Hadjigeorgiou G.M., Dardiotis E. (2021)
      Background: Alzheimer's (AD) and Parkinson's diseases (PD) share a few elements of their clinical, pathological and genetic backgrounds. The CD33 rs3865444 has emerged as a strong genetic locus associated with AD through ...

    • Challenges in developing methods for quantifying the effects of weather and climate on water-associated diseases: A systematic review 

      Lo Iacono G., Armstrong B., Fleming L.E., Elson R., Kovats S., Vardoulakis S., Nichols G.L. (2017)
      Infectious diseases attributable to unsafe water supply, sanitation and hygiene (e.g. Cholera, Leptospirosis, Giardiasis) remain an important cause of morbidity and mortality, especially in low-income countries. Climate ...

    • A computational fluid dynamics modelling of maternal-fetal heat exchange and blood flow in the umbilical cord 

      Kasiteropoulou D., Topalidou A., Downe S. (2020)
      Human fetal thermoregulation, maternal-fetal heat exchange, and the role of the umbilical cord in these processes are not well understood. Ethical and technical limitations have restricted current knowledge to animal ...

    • Cost-Effectiveness Analysis of Seven Measures to Reduce Tail Biting Lesions in Fattening Pigs 

      Niemi J.K., Edwards S.A., Papanastasiou D.K., Piette D., Stygar A.H., Wallenbeck A., Valros A. (2021)
      Tail biting is an important animal welfare issue in the pig sector. Studies have identified various risk factors which can lead to biting incidents and proposed mitigation measures. This study focused on the following seven ...

    • Dual IRE1 RNase functions dictate glioblastoma development 

      Lhomond S., Avril T., Dejeans N., Voutetakis K., Doultsinos D., McMahon M., Pineau R., Obacz J., Papadodima O., Jouan F., Bourien H., Logotheti M., Jégou G., Pallares-Lupon N., Schmit K., Le Reste P.-J., Etcheverry A., Mosser J., Barroso K., Vauléon E., Maurel M., Samali A., Patterson J.B., Pluquet O., Hetz C., Quillien V., Chatziioannou A., Chevet E. (2018)
      Proteostasis imbalance is emerging as a major hallmark of cancer, driving tumor aggressiveness. Evidence suggests that the endoplasmic reticulum (ER), a major site for protein folding and quality control, plays a critical ...

    • Effect of macroscale formation of intraluminal thrombus on blood flow in abdominal aortic aneurysms 

      Raptis A., Xenos M., Dimas S., Giannoukas A., Labropoulos N., Bluestein D., Matsagkas M.I. (2016)
      A mathematical approach of blood flow within an abdominal aortic aneurysm (AAA) with intraluminal thrombus (ILT) is presented. The macroscale formation of ILT is modeled as a growing porous medium with variable porosity ...

    • Effects of sheep/goat whey protein dietary supplementation on the redox status of rats 

      Kerasioti E., Stagos D., Tsatsakis A.M., Spandidos D.A., Taitzoglou I., Kouretas D. (2018)
      The purpose of the present study is to estimate the effects of sheep/goat whey protein dietary supplementation on the redox status of blood and tissues of rats. Twelve male Wistar rats were divided into the control group ...

    • Endograft Specific Haemodynamics After Endovascular Aneurysm Repair: Flow Characteristics of Four Stent Graft Systems 

      Raptis A., Xenos M., Spanos K., Kouvelos G., Giannoukas A., Matsagkas M. (2019)
      Objectives: The implication of haemodynamics in the occurrence of complications after endovascular aneurysm repair (EVAR) has been raised in the literature. Different aortic stent graft configurations may lead to different ...

    • Enhanced expression of miR-21 and miR-150 is a feature of anti-mitochondrial antibody-negative primary biliary cholangitis 

      Wasik U., Kempinska-Podhorodecka A., Bogdanos D.P., Milkiewicz P., Milkiewicz M. (2020)
      Background & Aims: Anti-mitochondrial-autoantibodies (AMA) remain a hallmark of Primary Biliary Cholangitis (PBC) however approximately 10% of patients test negative for these antibodies. They do not differ in terms of ...

    • Environmental parameters as risk factors for human and canine Leishmania infection in Thessaly, Central Greece 

      Giannakopoulos A., Tsokana C.N., Pervanidou D., Papadopoulos E., Papaspyropoulos K., Spyrou V., Rodi Burriel A., Vakali A., Hadjichristodoulou C., Billinis C. (2016)
      Thessaly, Central Greece, is an endemic area for leishmaniasis with higher incidence rate during the last years. We herein investigated the geographical distribution of human leishmaniasis cases and Leishmania infected ...

    • Evaluation of thermal perception in schoolyards under Mediterranean climate conditions 

      Antoniadis D., Katsoulas N., Papanastasiou D., Christidou V., Kittas C. (2016)
      The aim of this paper was to study qualitatively and quantitatively the thermal perception and corresponding heat stress conditions that prevail in two schoolyards in a coastal city in central Greece. For this purpose, ...

    • Genetic sharing with cardiovascular disease risk factors and diabetes reveals novel bone mineral density loci 

      Reppe S., Wang Y., Thompson W.K., McEvoy L.K., Schork A.J., Zuber V., LeBlanc M., Bettella F., Mills I.G., Desikan R.S., Djurovic S., Gautvik K.M., Dale A.M., Andreassen O.A., Estrada K., Styrkarsdottir U., Evangelou E., Hsu Y.-H., Duncan E.L., Ntzani E.E., Oei L., Albagha O.M.E., Amin N., Kemp J.P., Koller D.L., Li G., Liu C.-T., Minster R.L., Moayyeri A., Vandenput L., Willner D., Xiao S.-M., Yerges-Armstrong L.M., Zheng H.-F., Alonso N., Eriksson J., Kammerer C.M., Kaptoge S.K., Leo P.J., Thorleifsson G., Wilson S.G., Wilson J.F., Aalto V., Alen M., Aragaki A.K., Aspelund T., Center J.R., Dailiana Z., Duggan D.J., Garcia M., Garcia-Giralt N., Giroux S., Hallmans G., Hocking L.J., Husted L.B., Jameson K.A., Khusainova R., Kim G.S., Kooperberg C., Koromila T., Kruk M., Laaksonen M., Lacroix A.Z., Lee S.H., Leung P.C., Lewis J.R., Masi L., Mencej-Bedrac S., Nguyen T.V., Nogues X., Patel M.S., Prezelj J., Rose L.M., Scollen S., Siggeirsdottir K., Smith A.V., Svensson O., Trompet S., Trummer O., Van Schoor N.M., Woo J., Zhu K., Balcells S., Brandi M.L., Buckley B.M., Cheng S., Christiansen C., Cooper C., Dedoussis G., Ford I., Frost M., Goltzman D., González-Macías J., Kähönen M., Karlsson M., Khusnutdinova E., Koh J.-M., Kollia P., Langdahl B.L., Leslie W.D., Lips P., Ljunggren Ö., Lorenc R.S., Marc J., Mellström D., Obermayer-Pietsch B., Olmos J.M., Pettersson-Kymmer U., Reid D.M., Riancho J.A., Ridker P.M., Rousseau F., Slagboom P.E., Tang N.L.S., Urreizti R., Van Hul W., Viikari J., Zarrabeitia M.T., Aulchenko Y.S., Castano-Betancourt M., Grundberg E., Herrera L., Ingvarsson T., Johannsdottir H., Kwan T., Li R., Luben R., Medina-Gómez C., Palsson S.Th., Rotter J.I., Sigurdsson G., Van Meurs J.B.J., Verlaan D., Williams F.M.K., Wood A.R., Zhou Y., Pastinen T., Raychaudhuri S., Cauley J.A., Chasman D.I., Clark G.R., Cummings S.R., Danoy P., Dennison E.M., Eastell R., Eisman J.A., Gudnason V., Hofman A., Jackson R.D., Jones G., Jukema J.W., Khaw K.-T., Lehtimäki T., Liu Y., Lorentzon M., McCloskey E., Mitchell B.D., Nandakumar K., Nicholson G.C., Oostra B.A., Peacock M., Pols H.A.P., Prince R.L., Raitakari O., Reid I.R., Robbins J., Sambrook P.N., Sham P.C., Shuldiner A.R., Tylavsky F.A., Van Duijn C.M., Wareham N.J., Cupples L.A., Econs M.J., Evans D.M., Harris T.B., Kung A.W.C., Psaty B.M., Reeve J., Spector T.D., Streeten E.A., Zillikens M.C., Thorsteinsdottir U., Ohlsson C., Karasik D., Richards J.B., Brown M.A., Stefansson K., Uitterlinden A.G., Ralston S.H., Ioannidis J.P.A., Kiel D.P., Rivadeneira F., GEFOS Consortium (2015)
      Bone Mineral Density (BMD) is a highly heritable trait, but genome-wide association studies have identified few genetic risk factors. Epidemiological studies suggest associations between BMD and several traits and diseases, ...

    • Gonadotropin Surge-Attenuating Factor: A Nonsteroidal Ovarian Hormone Controlling GnRH-Induced LH Secretion in the Normal Menstrual Cycle 

      Messinis I.E., Messini C.I., Anifandis G., Garas A., Daponte A. (2018)
      Gonadotropin surge-attenuating factor (GnSAF) is a nonsteroidal ovarian substance, which attenuates the endogenous LH surge in superovulated women. Different molecular sequences have been found, but only one of them has ...

    • GWAR: Robust analysis and meta-analysis of genome-wide association studies 

      Dimou N.L., Tsirigos K.D., Elofsson A., Bagos P.G. (2017)
      Motivation: In the context of genome-wide association studies (GWAS), there is a variety of statistical techniques in order to conduct the analysis, but, in most cases, the underlying genetic model is usually unknown. Under ...

    • A homogenization model of the Voigt type for skeletal muscle 

      Spyrou L.A., Agoras M., Danas K. (2017)
      A three-dimensional constitutive model for skeletal muscle incorporating microstructural characteristics is developed and numerically implemented in a general purpose finite element program. The proposed model takes into ...

    • Host – virus – drug interactions as determinants of COVID-19’s phenotypes: A data-driven hypothesis 

      Vavougios G.D. (2020)
      There is a growing body of evidence on the significance of interactions between comorbidities, their treatments and COVID-19 clinical phenotypes. The hypothesis explored herein is that pharmaceutical compounds currently ...