Πλοήγηση ανά Θέμα "POLYMORPHISM"
Αποτελέσματα 1-20 από 28
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ACE (I/D) polymorphism and response to treatment in coronary artery disease: a comprehensive database and meta-analysis involving study quality evaluation
(2009)Background: The role of angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism in modifying the response to treatment modalities in coronary artery disease is controversial. Methods: PubMed was ... -
Apolipoprotein E polymorphism is not associated with spinal bone mineral density in peri- and postmenopausal Greek women
(2004)Objectives: A number of studies have shown a positive relation between ApoE gene and osteoporosis or fracture risk but this finding has not been uniform in all populations studied. The aim of the present study was to ... -
AR CAG repeat length is not associated with serum gonadal steroids and lipid levels in healthy men
(2009)P>Cardiovascular risk factors seem to be affected by androgens, which exert their action through the androgen receptor (AR). Androgenic action correlates inversely with a polymorphic CAG repeat region in the AR gene encoding ... -
Assessment of Osteoarthritis Candidate Genes in a Meta-Analysis of Nine Genome-Wide Association Studies
(2014)Objective. To assess candidate genes for association with osteoarthritis (OA) and identify promising genetic factors and, secondarily, to assess the candidate gene approach in OA. Methods. A total of 199 candidate genes ... -
The association between plasminogen activator inhibitor type 1 (PAI-1) levels, PAI-1 4G/5G polymorphism, and myocardial infarction: a Mendelian randomization meta-analysis
(2014)Background: The circulating levels of plasminogen activator inhibitor type 1 (PAI-1) are increased in individuals carrying the 4G allele at position -675 of the PAI-1 gene. In turn, overexpression of PAI-1 has been found ... -
beta-Glucocerebrosidase gene mutations in two cohorts of Greek patients with sporadic Parkinson's disease
(2011)An increasing number of clinical, neuropathological and experimental evidence linking Gaucher disease and a spectrum of synucleinopathies, including Parkinson's disease (PD) has emerged over the last decade. In particular, ... -
Chromosome analyses challenge the taxonomic position of Augosoma centaurus Fabricius, 1775 (Coleoptera: Scarabaeidae: Dynastinae) and the separation of Dynastini and Oryctini
(2013)Augosoma centaurus Fabricius, 1775 (Melolonthidae: Dynastinae), one of the largest Scarabaeoid beetles of the Ethiopian Region, is classified in the tribe Dynastini MacLeay, 1819, principally on the basis of morphological ... -
Deep sequencing of GDF5 reveals the absence of rare variants at this important osteoarthritis susceptibility locus
(2011)Objective: The common single nucleotide polymorphism (SNP) rs143383 in the 5' untranslated region (5'UTR) of growth and differentiation factor 5 (GDF5) is strongly associated with osteoarthritis (OA) and influences GDF5 ... -
Domestication does not narrow MHC diversity in Sus scrofa
(2013)The Major Histocompatibility Complex (MHC) is a multigene family of outstanding polymorphism. MHC molecules bind antigenic peptides in the peptide-binding region (PBR) that consists of five binding pockets (P). In this ... -
Effectiveness of SSR molecular markers in evaluating the phylogenetic relationships among eight Actinidia species
(2008)The aim of the present study is to evaluate a set of microsatellites and their effectiveness in determining the phylogenetic relationships among Actinidia species. A set of 14 genotypes belonging to eight Actinidia species ... -
A Field Synopsis and Meta-Analysis of Genetic Association Studies in Peripheral Arterial Disease: The CUMAGAS-PAD Database
(2009)In an electronic search of the literature, the authors systematically retrieved all published studies that investigated genetic susceptibility to peripheral arterial disease (PAD). They created a comprehensive database of ... -
Generalized least squares for assessing trends in cumulative meta-analysis with applications in genetic epidemiology
(2009)Objective: Cumulative meta-analysis allows the evaluation of a study's contribution to the combined effect of the preceding research. It accrues evidence, gradually adding studies one at a time and provides updated estimates ... -
Genetic factors influencing outcome from neurotrauma
(2012)Purpose of review Clinical outcome after neurotrauma is considerably variable and can only partly be explained by known prognostic factors. There is converging evidence from genetic research that a number of genetic variants ... -
Genetic variation among Mediterranean populations of Sesamia nonagrioides (Lepidoptera : Noctuidae) as revealed by RFLP mtDNA analysis
(2007)Restriction fragment length polymorphism analysis of two segments of mitochondrial DNA (COI and 16S rRNA) was used to examine genetic variation in Sesamia nonagrioides (Lefebvre) populations from the Mediterranean basin. ... -
Genotype 4 HCV infection is difficult to cure with pegylated interferon and ribavirin. Results from a Greek Nationwide Cohort Study
(2014)Background and aim: Patients with genotype 4 (G4) chronic hepatitis C (CHC) are considered a difficult to treat population, although current data on G4 treatment responsiveness and duration are controversial. Greece ... -
Genotyping Plasmodium vivax isolates from the 2011 outbreak in Greece
(2013)Background: Plasmodium vivax malaria was common in Greece until the 1950s with epidemics involving thousands of cases every year. Greece was declared free of malaria by the World Health Organization in 1974. From 1974 to ... -
Gilbert Syndrome as a Predisposing Factor for Cholelithiasis Risk in the Greek Adult Population
(2009)We investigated the hypothesis that coinheritance of the common A(TA)(n)TAA promoter mutation at the UGT1A1 locus associated with Gilbert syndrome is a risk factor for gallstone formation in a homogeneous adult population, ... -
Impact of ACE and ApoE polymorphisms on myocardial perfusion: correlation with myocardial single photon emission computed tomographic imaging
(2009)Coronary artery disease is associated with multiple genetic and environmental risk factors. In this study, we evaluated the correlation of angiotensin l-converting enzyme (ACE) (I/D) and ApoE gene polymorphisms (E2, E3, ... -
Individualization of chronic hepatitis C treatment according to the host characteristics
(2014)Hepatitis C virus (HCV) infection is a global health problem that affects more than 170 million people worldwide. It is a major cause of cirrhosis and hepatocellular carcinoma, making the virus the most common cause of ... -
Is catechol-O-methyl transferase 472G/A gene polymorphism a marker associated with alcoholism?
(2011)Objectives The available published evidence from the genetic association studies on the association between alcoholism and catechol-O-methyl transferase 472G/A gene polymorphism have produced inconclusive results. To ...