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Sfoglia per Soggetto "Macular Degeneration"

Items 1-10 di 10

    • Anti-platelet effects of vitamin supplements in age-related macular degeneration: an in vitro study 

      Moschos M.M., Laios K., Androudi S., Ladas D.S., Chatziralli I.P. (2018)
      Objective: The purpose of this experimental study was to investigate the role of vitamin supplements (Ocuvite, Vitalux Omega, and Nutrof Total) as possible inhibitors of the onset of age-related macular degeneration (AMD). ...

    • Causes of blindness and vision impairment in 2020 and trends over 30 years, and prevalence of avoidable blindness in relation to VISION 2020: The Right to Sight: An analysis for the Global Burden of Disease Study 

      Bourne R.R.A., Steinmetz J.D., Saylan M., Mersha A.M., Weldemariam A.H., Wondmeneh T.G., Sreeramareddy C.T., Pinheiro M., Yaseri M., Yu C., Zastrozhin M.S., Zastrozhina A., Zhang Z.-J., Zimsen S.R.M., Yonemoto N., Tsegaye G.W., Vu G.T., Vongpradith A., Renzaho A.M.N., Sorrie M.B., Shaheen A.A., Shiferaw W.S., Skryabin V.Y., Skryabina A.A., Saya G.K., Rahimi-Movaghar V., Shigematsu M., Sahraian M.A., Naderifar H., Sabour S., Rathi P., Sathian B., Miller T.R., Rezapour A., Rawal L., Pham H.Q., Parekh U., Podder V., Onwujekwe O.E., Pasovic M., Otstavnov N., Negash H., Pawar S., Naimzada M.D., Al Montasir A., Ogbo F.A., Owolabi M.O., Pakshir K., Mohammad Y., Moni M.A., Nunez-Samudio V., Mulaw G.F., Naveed M., Maleki S., Michalek I.M., Misra S., Swamy S.N., Mohammed J.A., Flaxman S., Park E.-C., Briant P.S., Meles G.G., Hayat K., Landires I., Kim G.R., Liu X., LeGrand K.E., Taylor H.R., Kunjathur S.M., Khoja T.A.M., Bicer B.K., Khalilov R., Hashi A., Kayode G.A., Carneiro V.L.A., Kavetskyy T., Kosen S., Kulkarni V., Holla R., Kalhor R., Jayaram S., Islam S.M.S., Gilani S.A., Eskandarieh S., Molla M.D., Itumalla R., Farzadfar F., Congdon N.G., Elhabashy H.R., Elayedath R., Couto R.A.S., Dervenis N., Cromwell E.A., Dahlawi S.M.A., Resnikoff S., Casson R.J., Abdoli A., Choi J.-Y.J., Dos Santos F.L.C., Abrha W.A., Nagaraja S.B., Abualhasan A., Adal T.G., Aregawi B.B., Beheshti M., Abu-Gharbieh E., Afshin A., Ahmadieh H., Alemzadeh S.A., Arrigo A., Atnafu D.D., Ashbaugh C., Ashrafi E., Alemayehu W., Alfaar A.S., Alipour V., Anbesu E.W., Androudi S., Arabloo J., Arditi A., Bagli E., Baig A.A., Bärnighausen T.W., Parodi M.B., Bhagavathula A.S., Bhardwaj N., Bhardwaj P., Bhattacharyya K., Bijani A., Bikbov M., Bottone M., Braithwaite T., Bron A.M., Butt Z.A., Cheng C.-Y., Chu D.-T., Cicinelli M.V., Coelho J.M., Dai X., Dana R., Dandona L., Dandona R., Del Monte M.A., Deva J.P., Diaz D., Djalalinia S., Dreer L.E., Ehrlich J.R., Ellwein L.B., Emamian M.H., Fernandes A.G., Fischer F., Friedman D.S., Furtado J.M., Gaidhane S., Gazzard G., Gebremichael B., George R., Ghashghaee A., Golechha M., Hamidi S., Hammond B.R., Hartnett M.E.R., Hartono R.K., Hay S.I., Heidari G., Ho H.C., Househ M., Ibitoye S.E., Ilic I.M., Huang J.J., Ilic M.D., Ingram A.D., Irvani S.S.N., Jha R.P., Kahloun R., Kandel H., Kasa A.S., Kempen J.H., Khairallah M., Khan E.A., Khanna R.C., Khatib M.N., Kim J.E., Kim Y.J., Kisa A., Kisa S., Koyanagi A., Kurmi O.P., Lansingh V.C., Leasher J.L., Leveziel N., Limburg H., Manafi N., Mansouri K., McAlinden C., Mohammadi S.F., Mokdad A.H., Morse A.R., Naderi M., Naidoo K.S., Nangia V., Nguyen H.L.T., Ogundimu K., Olagunju A.T., Panda-Jonas S., Pesudovs K., Peto T., Ur Rahman M.H., Ramulu P.Y., Rawaf D.L., Rawaf S., Reinig N., Robin A.L., Rossetti L., Safi S., Sahebkar A., Samy A.M., Serle J.B., Shaikh M.A., Shen T.T., Shibuya K., Shin J.I., Silva J.C., Silvester A., Singh J.A., Singhal D., Sitorus R.S., Skiadaresi E., Soheili A., Sousa R.A.R.C., Stambolian D., Tadesse E.G., Tahhan N., Tareque Md.I., Topouzis F., Tran B.X., Tsilimbaris M.K., Varma R., Virgili G., Wang N., Wang Y.X., West S.K., Wong T.Y., Jonas J.B., Vos T., GBD 2019 Blindness and Vision Impairment Collaborators, Vision Loss Expert Group of the Global Burden of Disease Study (2021)
      Background: Many causes of vision impairment can be prevented or treated. With an ageing global population, the demands for eye health services are increasing. We estimated the prevalence and relative contribution of ...

    • Convergence of linkage, gene expression and association data demonstrates the influence of the RAR-related orphan receptor alpha (RORA) gene on neovascular AMD: A systems biology based approach 

      Silveira, A. C.; Morrison, M. A.; Ji, F.; Xu, H.; Reinecke, J. B.; Adams, S. M.; Arneberg, T. M.; Janssian, M.; Lee, J. E.; Yuan, Y.; Schaumberg, D. A.; Kotoula, M. G.; Tsironi, E. E.; Tsiloulis, A. N.; Chatzoulis, D. Z.; Miller, J. W.; Kim, I. K.; Hageman, G. S.; Farrer, L. A.; Haider, N. B.; DeAngelis, M. M. (2010)
      To identify novel genes and pathways associated with AMD, we performed microarray gene expression and linkage analysis which implicated the candidate gene, retinoic acid receptor-related orphan receptor alpha (RORA, 15q). ...

    • Influence of ROBO1 and RORA on risk of age-related macular degeneration reveals genetically distinct phenotypes in disease pathophysiology 

      Jun, G.; Nicolaou, M.; Morrison, M. A.; Buros, J.; Morgan, D. J.; Radeke, M. J.; Yonekawa, Y.; Tsironi, E. E.; Kotoula, M. G.; Zacharaki, F.; Mollema, N.; Yuan, Y.; Miller, J. W.; Haider, N. B.; Hageman, G. S.; Kim, I. K.; Schaumberg, D. A.; Farrer, L. A.; DeAngelis, M. M. (2011)
      ROBO1 is a strong candidate gene for age-related macular degeneration (AMD) based upon its location under a linkage peak on chromosome 3p12, its expression pattern, and its purported function in a pathway that includes ...

    • A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants 

      Fritsche L.G., Igl W., Bailey J.N.C., Grassmann F., Sengupta S., Bragg-Gresham J.L., Burdon K.P., Hebbring S.J., Wen C., Gorski M., Kim I.K., Cho D., Zack D., Souied E., Scholl H.P.N., Bala E., ELee K., Hunter D.J., Sardell R.J., Mitchell P., Merriam J.E., Cipriani V., Hoffman J.D., Schick T., Lechanteur Y.T.E., Guymer R.H., Johnson M.P., Jiang Y., Stanton C.M., Buitendijk G.H.S., Zhan X., Kwong A.M., Boleda A., Brooks M., Gieser L., Ratnapriya R., Branham K.E., Foerster J.R., Heckenlively J.R., Othman M.I., Vote B.J., Liang H.H., Souzeau E., McAllister I.L., Isaacs T., Hall J., Lake S., Mackey D.A., Constable I.J., Craig J.E., Kitchner T.E., Yang Z., Su Z., Luo H., Chen D., Ouyang H., Flagg K., Lin D., Mao G., Ferreyra H., Stark K., Von Strachwitz C.N., Wolf A., Brandl C., Rudolph G., Olden M., Morrison M.A., Morgan D.J., Schu M., Ahn J., Silvestri G., Tsironi E.E., Park K.H., Farrer L.A., Orlin A., Brucker A., Li M., Curcio C.A., Mohand-Sa'd S., Sahel J.-A., Audo I., Benchaboune M., Cree A.J., Rennie C.A., Goverdhan S.V., Grunin M., Hagbi-Levi S., Campochiaro P., Katsanis N., Holz F.G., Blond F., Blanché H., Deleuze J.-F., Igo R.P., Jr., Truitt B., Peachey N.S., Meuer S.M., Myers C.E., Moore E.L., Klein R., Hauser M.A., Postel E.A., Courtenay M.D., Schwartz S.G., Kovach J.L., Scott W.K., Liew G., Tan A.G., Gopinath B., Merriam J.C., Smith R.T., Khan J.C., Shahid H., Moore A.T., McGrath J.A., Laux R., Brantley M.A., Jr., Agarwal A., Ersoy L., Caramoy A., Langmann T., Saksens N.T.M., Jong E.K., Hoyng C.B., Cain M.S., Richardson A.J., Martin T.M., Blangero J., Weeks D.E., Dhillon B., Van Duijn C.M., Doheny K.F., Romm J., Klaver C.C.W., Hayward C., Gorin M.B., Klein M.L., Baird P.N., Den Hollander A.I., Fauser S., WYates J.R., Allikmets R., Wang J.J., Schaumberg D.A., Klein B.E.K., Hagstrom S.A., Chowers I., Lotery A.J., Léveillard T., Zhang K., Brilliant M.H., Hewitt A.W., Swaroop A., Chew E.Y., Pericak-Vance M.A., DeAngelis M., Stambolian D., Haines J.L., Iyengar S.K., Weber B.H.F., Abecasis G.R., Heid I.M. (2016)
      Advanced age-related macular degeneration (AMD) is the leading cause of blindness in the elderly, with limited therapeutic options. Here we report on a study of >12 million variants, including 163,714 directly genotyped, ...

    • Quality-adjusted life years in macular oedema due to age-related macular degeneration, diabetes and central retinal vein occlusion: the impact of anti-VEGF agents in a tertiary centre in Greece 

      Voutsas N.T., Papageorgiou E., Tantou A., Dimitriou V.A., Tsironi E.E., Kotoula M. (2022)
      Introduction: Neovascular age-related macular degeneration (nAMD), diabetic macular oedema (DME), and macular oedema due to central retinal vein occlusion (CRVO) are leading causes of vision loss, currently managed with ...

    • Seven new loci associated with age-related macular degeneration 

      Fritsche, L. G.; Chen, W.; Schu, M.; Yaspan, B. L.; Yu, Y.; Thorleifsson, G.; Zack, D. J.; Arakawa, S.; Cipriani, V.; Ripke, S.; Igo, R. P.; Buitendijk, G. H. S.; Sim, X.; Weeks, D. E.; Guymer, R. H.; Merriam, J. E.; Francis, P. J.; Hannum, G.; Agarwal, A.; Armbrecht, A. M.; Audo, I.; Aung, T.; Barile, G. R.; Benchaboune, M.; Bird, A. C.; Bishop, P. N.; Branham, K. E.; Brooks, M.; Brucker, A. J.; Cade, W. H.; Cain, M. S.; Campochiaro, P. A.; Chan, C. C.; Cheng, C. Y.; Chew, E. Y.; Chin, K. A.; Chowers, I.; Clayton, D. G.; Cojocaru, R.; Conley, Y. P.; Cornes, B. K.; Daly, M. J.; Dhillon, B.; Edwards, A. O.; Evangelou, E.; Fagerness, J.; Ferreyra, H. A.; Friedman, J. S.; Geirsdottir, A.; George, R. J.; Gieger, C.; Gupta, N.; Hagstrom, S. A.; Harding, S. P.; Haritoglou, C.; Heckenlively, J. R.; Holz, F. G.; Hughes, G.; Ioannidis, J. P. A.; Ishibashi, T.; Joseph, P.; Jun, G.; Kamatani, Y.; Katsanis, N.; N Keilhauer, C.; Khan, J. C.; Kim, I. K.; Kiyohara, Y.; Klein, B. E. K.; Klein, R.; Kovach, J. L.; Kozak, I.; Lee, C. J.; Lee, K. E.; Lichtner, P.; Lotery, A. J.; Meitinger, T.; Mitchell, P.; Mohand-Saïd, S.; Moore, A. T.; Morgan, D. J.; Morrison, M. A.; Myers, C. E.; Naj, A. C.; Nakamura, Y.; Okada, Y.; Orlin, A.; Ortube, M. C.; Othman, M. I.; Pappas, C.; Park, K. H.; Pauer, G. J. T.; Peachey, N. S.; Poch, O.; Priya, R. R.; Reynolds, R.; Richardson, A. J.; Ripp, R.; Rudolph, G.; Ryu, E.; Sahel, J. A.; Schaumberg, D. A.; Scholl, H. P. N.; Schwartz, S. G.; Scott, W. K.; Shahid, H.; Sigurdsson, H.; Silvestri, G.; Sivakumaran, T. A.; Smith, R. T.; Sobrin, L.; Souied, E. H.; Stambolian, D. E.; Stefansson, H.; Sturgill-Short, G. M.; Takahashi, A.; Tosakulwong, N.; Truitt, B. J.; Tsironi, E. E.; Uitterlinden, A. G.; Van Duijn, C. M.; Vijaya, L.; Vingerling, J. R.; Vithana, E. N.; Webster, A. R.; Wichmann, H. E.; Winkler, T. W.; Wong, T. Y.; Wright, A. F.; Zelenika, D.; Zhang, M.; Zhao, L.; Zhang, K.; Klein, M. L.; Hageman, G. S.; Lathrop, G. M.; Stefansson, K.; Allikmets, R.; Baird, P. N.; Gorin, M. B.; Wang, J. J.; Klaver, C. C. W.; Seddon, J. M.; Pericak-Vance, M. A.; Iyengar, S. K.; Yates, J. R. W.; Swaroop, A.; Weber, B. H. F.; Kubo, M.; Deangelis, M. M.; Léveillard, T.; Thorsteinsdottir, U.; Haines, J. L.; Farrer, L. A.; Heid, I. M.; Abecasis, G. R. (2013)
      Age-related macular degeneration (AMD) is a common cause of blindness in older individuals. To accelerate the understanding of AMD biology and help design new therapies, we executed a collaborative genome-wide association ...

    • Systems biology-based analysis implicates a novel role for vitamin D metabolism in the pathogenesis of age-related macular degeneration 

      Morrison, M. A.; Silveira, A. C.; Huynh, N.; Jun, G.; Smith, S. E.; Zacharaki, F.; Sato, H.; Loomis, S.; Andreoli, M. T.; Adams, S. M.; Radeke, M. J.; Jelcick, A. S.; Yuan, Y.; Tsiloulis, A. N.; Chatzoulis, D. Z.; Silvestri, G.; Kotoula, M. G.; Tsironi, E. E.; Hollis, B. W.; Chen, R.; Haider, N. B.; Miller, J. W.; Farrer, L. A.; Hageman, G. S.; Kim, I. K.; Schaumberg, D. A.; DeAngelis, M. M. (2011)
      Vitamin D has been shown to have anti-angiogenic properties and to play a protective role in several types of cancer, including breast, prostate and cutaneous melanoma. Similarly, vitamin D levels have been shown to be ...

    • A transcriptome-wide association study based on 27 tissues identifies 106 genes potentially relevant for disease pathology in age-related macular degeneration 

      Strunz T., Lauwen S., Kiel C., Fritsche L.G., Igl W., Bailey J.N.C., Grassmann F., Sengupta S., Bragg-Gresham J.L., Burdon K.P., Hebbring S.J., Wen C., Gorski M., Kim I.K., Cho D., Zack D., Souied E., Scholl H.P.N., Bala E., Lee K.E., Hunter D.J., Sardell R.J., Mitchell P., Merriam J.E., Cipriani V., Hoffman J.D., Schick T., Lechanteur Y.T.E., Guymer R.H., Johnson M.P., Jiang Y., Stanton C.M., Buitendijk G.H.S., Zhan X., Kwong A.M., Boleda A., Brooks M., Gieser L., Ratnapriya R., Branham K.E., Foerster J.R., Heckenlively J.R., Othman M.I., Vote B.J., Liang H.H., Souzeau E., McAllister I.L., Isaacs T., Hall J., Lake S., Mackey D.A., Constable I.J., Craig J.E., Kitchner T.E., Yang Z., Su Z., Luo H., Chen D., Ouyang H., Flagg K., Lin D., Mao G., Ferreyra H., Stark K., Strachwitz C.N., Wolf A., Brandl C., Rudolph G., Olden M., Morrison M.A., Morgan D.J., Schu M., Ahn J., Silvestri G., Tsironi E.E., Park K.H., Farrer L.A., Orlin A., Brucker A., Li M., Curcio C., Mohand-Saïd S., Sahel J.-A., Audo I., Benchaboune M., Cree A.J., Rennie C.A., Goverdhan S.V., Grunin M., Hagbi-Levi S., Campochiaro P., Katsanis N., Holz F.G., Blond F., Blanché H., Deleuze J.-F., Igo R.P., Jr., Truitt B., Peachey N.S., Meuer S.M., Myers C.E., Moore E.L., Klein R., Hauser M.A., Postel E.A., Courtenay M.D., Schwartz S.G., Kovach J.L., Scott W.K., Liew G., Tfan A.G., Gopinath B., Merriam J.C., Smith R.T., Khan J.C., Shahid H., Moore A.T., McGrath J.A., Laux R., Brantley M.A., Jr., Agarwal A., Ersoy L., Caramoy A., Langmann T., Saksens N.T.M., Jong E.K., Hoyng C.B., Cain M.S., Richardson A.J., Martin T.M., Blangero J., Weeks D.E., Dhillon B., Duijn C.M., Doheny K.F., Romm J., Klaver C.C.W., Hayward C., Gorin M.B., Klein M.L., Baird P.N., Hollander A.I., Fauser S., Yates J.R.W., Allikmets R., Wang J.J., Schaumberg D.A., Klein B.E.K., Hagstrom S.A., Chowers I., Lotery A.J., Léveillard T., Zhang K., Brilliant M.H., Hewitt A.W., Swaroop A., Chew E.Y., Pericak-Vance M.A., DeAngelis M., Stambolian D., Haines J.L., Iyengar S.K., Weber B.H.F., Abecasis G.R., Heid I.M., Hollander A., Weber B.H.F., International AMD Genomics Consortium (IAMDGC) (2020)
      Genome-wide association studies (GWAS) for late stage age-related macular degeneration (AMD) have identified 52 independent genetic variants with genome-wide significance at 34 genomic loci. Typically, such an approach ...

    • Trends in prevalence of blindness and distance and near vision impairment over 30 years: An analysis for the Global Burden of Disease Study 

      Bourne R.R.A., Steinmetz J.D., Flaxman S., Briant P.S., Taylor H.R., Resnikoff S., Casson R.J., Abdoli A., Abu-Gharbieh E., Afshin A., Ahmadieh H., Akalu Y., Alamneh A.A., Alemayehu W., Alfaar A.S., Alipour V., Anbesu E.W., Androudi S., Arabloo J., Arditi A., Asaad M., Bagli E., Baig A.A., Bärnighausen T.W., Parodi M.B., Bhagavathula A.S., Bhardwaj N., Bhardwaj P., Bhattacharyya K., Bijani A., Bikbov M., Bottone M., Braithwaite T., Bron A.M., Butt Z.A., Cheng C.-Y., Chu D.-T., Cicinelli M.V., Coelho J.M., Dagnew B., Dai X., Dana R., Dandona L., Dandona R., Del Monte M.A., Deva J.P., Diaz D., Djalalinia S., Dreer L.E., Ehrlich J.R., Ellwein L.B., Emamian M.H., Fernandes A.G., Fischer F., Friedman D.S., Furtado J.M., Gaidhane A.M., Gaidhane S., Gazzard G., Gebremichael B., George R., Ghashghaee A., Golechha M., Hamidi S., Hammond B.R., Hartnett M.E.R., Hartono R.K., Hay S.I., Heidari G., Ho H.C., Hoang C.L., Househ M., Ibitoye S.E., Ilic I.M., Ilic M.D., Ingram A.D., Irvani S.S.N., Jha R.P., Kahloun R., Kandel H., Kasa A.S., Kempen J.H., Keramati M., Khairallah M., Khan E.A., Khanna R.C., Khatib M.N., Kim J.E., Kim Y.J., Kisa A., Kisa S., Koyanagi A., Kurmi O.P., Lansingh V.C., Leasher J.L., Leveziel N., Limburg H., Majdan M., Manafi N., Mansouri K., McAlinden C., Mohammadi S.F., Mohammadian-Hafshejani A., Mohammadpourhodki R., Mokdad A.H., Moosavi D., Morse A.R., Naderi M., Naidoo K.S., Nangia V., Nguyen C.T., Nguyen H.L.T., Ogundimu K., Olagunju A.T., Ostroff S.M., Panda-Jones S., Pesudovs K., Peto T., Syed Z.Q., Ur Rahman M.H., Ramulu P.Y., Rawaf D.L., Rawaf S., Reinig N., Robin A.L., Rossetti L., Safi S., Sahebkar A., Samy A.M., Saxena D., Serle J.B., Shaikh M.A., Shen T.T., Shibuya K., Shin J.I., Silva J.C., Silvester A., Singh J.A., Singhal D., Sitorus R.S., Skiadaresi E., Skirbekk V., Soheili A., Sousa R.A.R.C., Spurlock E.E., Stambolian D., Taddele B.W., Tadesse E.G., Tahhan N., Tareque Md.I., Topouzis F., Tran B.X., Travillian R.S., Tsilimbaris M.K., Varma R., Virgili G., Wang N., Wang Y.X., West S.K., Wong T.Y., Zaidi Z., Zewdie K.A., Jonas J.B., Vos T., GBD 2019 Blindness and Vision Impairment Collaborators, Vision Loss Expert Group of the Global Burden of Disease Study (2021)
      Background: To contribute to the WHO initiative, VISION 2020: The Right to Sight, an assessment of global vision impairment in 2020 and temporal change is needed. We aimed to extensively update estimates of global vision ...