Browsing by Subject "DNA repair"
Now showing items 1-20 of 21
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Biomarkers in prostate-specific membrane antigen theranostics
(2021)Theranostics of prostate cancer (PC) represents a growing area of development of imaging agents and targeted radionuclide therapeutics against a major target, prostate specific membrane antigen (PSMA). In view of the ... -
Bridging plant and human radiation response and DNA repair through an in silico approach
(2017)The mechanisms of response to radiation exposure are conserved in plants and animals. The DNA damage response (DDR) pathways are the predominant molecular pathways activated upon exposure to radiation, both in plants and ... -
DNA damage and repair capacity in lymphocytes from obstructive sleep apnea patients
(2007)Obstructive sleep apnea (OSA) syndrome is a respiratory disease that is linked to heart attacks and high blood pressure. In the present study, we used the Comet assay to compare basal DNA damage and DNA damage induction ... -
DNA damage and repair in obstructive sleep apnea syndrome
(2005)The Obstructive Sleep Apnea is a respiratory disorder characterized by short breathing pauses during sleep. These pauses vary according to the Apnea type and the severity of the case. People suffering from Obstructive Sleep ... -
Dna repair gene polymorphisms and susceptibility to urothelial carcinoma in a southeastern european population
(2021)Single nucleotide polymorphisms (SNPs) in DNA repair genes may predispose to urothelial carcinoma of the bladder (UCB). This study focused on three specific SNPs in a population with high exposure to environmental carcinogens ... -
Dysregulation of caveolin-1 phosphorylation and nuclear translocation is associated with senescence onset
(2021)We recently reported that the inability of osteoarthritic (OA) chondrocytes to repair oxidative stress (OS) induced DNA damage is linked to Cav-1 overexpression/improper localization. We speculated that the senescent status ... -
Effects of pesticides on exposed populations from four European countries
(2008)The potential genetic hazard of pesticides to humans is of great concern, in particular in occupational and environmental settings because of their widespread use for domestic and industrial applications. In the present ... -
Effects of pesticides on occupationally exposed humans
(2006)Pesticides are known to contain numerous genotoxic compounds; however, genotoxicity biomonitoring studies of workers occupationally exposed to pesticides have produced variable results. In this study, we employed the Comet ... -
Emerging molecular networks common in ionizing radiation, immune and inflammatory responses by employing bioinformatics approaches
(2015)Efficient radiation therapy is characterized by enhanced tumor cell killing involving the activation of the immune system (tumor immunogenicity) but at the same time minimizing chronic inflammation and radiation adverse ... -
Familial partial lipodystrophy (FPLD): Recent insights
(2020)Lipodystrophies are a heterogeneous group of congenital or acquired disorders, characterized by partial or generalized loss of adipose tissue. Familial partial lipodystrophy (FPLD) presents with genetic and phenotypic ... -
FV vectors as alternative gene vehicles for gene transfer in HSCs
(2020)Hematopoietic Stem Cells (HSCs) are a unique population of cells, capable of reconstituting the blood system of an organism through orchestrated self-renewal and differentiation. They play a pivotal role in stem cell ... -
Investigating Molecular Determinants of Cancer Cell Resistance to Ionizing Radiation Through an Integrative Bioinformatics Approach
(2021)Eradication of cancer cells through exposure to high doses of ionizing radiation (IR) is a widely used therapeutic strategy in the clinical setting. However, in many cases, cancer cells can develop remarkable resistance ... -
Investigation of the Genotoxic Effect of Pesticides on Greenhouse Workers' Lymphocytes
(2009)In the present study, the genotoxic effects of commonly applied pesticides were evaluated using the alkaline comet assay (pH > 13). The amount of DNA damage (% DNA in tail) in peripheral lymphocytes of 49 male agricultural ... -
Loss of heterozygosity in DNA mismatch repair genes in human atherosclerotic plaques
(2001)To detect the incidence of loss of heterozygosity (LOH) in DNA mismatch repair genes (MMR) occurring in atherosclerosis, fifty human autopsy cases of atherosclerosis were examined for LOH using 19 microsatellite markers, ... -
Measuring the effects of pesticides on occupationally exposed humans with the comet assay
(2006)In this study we examine the effects of a mixture of pesticides on occupationally exposed agricultural workers. The study was performed on 149 people, 84 agricultural workers and 65 healthy men from the same area, who ... -
MGMT immunohistochemistry in pituitary tumors: controversies with clinical implications
(2019)Introduction: Temozolomide (TMZ) is currently considered as a rational therapeutic option for patients with progressively aggressive pituitary adenomas and carcinomas not responding to conventional therapies. Administration ... -
Mitochondrial tRNA mutations: Clinical and functional perturbations
(2007)During the last decade, there has been a progressive accumulation of reports that connect the identification of specific mitochondrial tRNA gene mutations to severe disorders in human. As a result, mitochondrial tRNA genes ... -
Molecular determinants of radiosensitivity in normal and tumor tissue: A bioinformatic approach
(2017)Although radiation therapy is a treatment of choice for cancer, a high percentage of patients develop adverse effects in normal tissue following radiotherapy, mainly, due to genetic factors. Notably, although it is established ... -
Unraveling the mechanisms of extreme radioresistance in prokaryotes: Lessons from nature
(2016)The last 50 years, a variety of archaea and bacteria able to withstand extremely high doses of ionizing radiation, have been discovered. Several lines of evidence suggest a variety of mechanisms explaining the extreme ... -
The use of comet assay in measuring DNA damage and repair efficiency in child, adult, and old age populations
(2009)In the present study, we used the Comet assay to estimate basal DNA damage in three distinct populations aged 5-10, 40-50, and 60-70 years old. The DNA damage induced by hydrogen peroxide and gamma-irradiation in the ...