Πλοήγηση ανά Θέμα "DNA Damage"
Αποτελέσματα 1-10 από 10
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Cellular communication network 2 (connective tissue growth factor) aggravates acute DNA damage and subsequent DNA damage response-senescence-fibrosis following kidney ischemia reperfusion injury
(2022)Chronic allograft dysfunction with progressive fibrosis of unknown cause remains a major issue after kidney transplantation, characterized by ischemia-reperfusion injury (IRI). One hypothesis to account for this is that ... -
DNA damage and differential gene expression associated with physical stress in gilthead seabream (Sparus aurata)
(2016)Fish stress may result in inhibition of reproduction, development and growth. Thus, appropriate indices should be developed to accurately define the physiological plasticity of fish, in terms of coping with stress. Sea ... -
Dysregulation of caveolin-1 phosphorylation and nuclear translocation is associated with senescence onset
(2021)We recently reported that the inability of osteoarthritic (OA) chondrocytes to repair oxidative stress (OS) induced DNA damage is linked to Cav-1 overexpression/improper localization. We speculated that the senescent status ... -
Evaluation of the genetic damage to workers in a Greek shipyard
(2022)Shipyards are industrial areas where workers are likely exposed to environmental pollutants such as welding fumes, fine organic solvent and dye dust, that render the occupational environment a high risk one. Assessing the ... -
Grape stem extracts from three native Greek vine varieties exhibit strong antioxidant and antimutagenic properties
(2020)Background/Aim: The winemaking procedure results in the generation of stems, a by-product that is harmful to the environment. Concomitantly, stems are rich in polyphenols and, hence, they are putatively beneficial for human ... -
Human mesenchymal stem cells with enhanced telomerase activity acquire resistance against oxidative stress-induced genomic damage
(2017)Background Human mesenchymal stem cells (MSC) are important tools for several cell-based therapies. However, their use in such therapies requires in vitro expansion during which MSCs quickly reach replicative senescence. ... -
The labdane diterpene sclareol (labd-14-ene-8, 13-diol) induces apoptosis in human tumor cell lines and suppression of tumor growth in vivo via a p53-independent mechanism of action
(2011)The labdane diterpene sclareol has demonstrated significant cytotoxicity against human tumor cell lines and human colon cancer xenografts. Therefore, there is need to elucidate the mode of action of this compound as very ... -
MacroDevelopment of an assay to assess genotoxicity by particulate matter extract
(2017)The current study describes a method for assessing the oxidative potential of common environmental stressors (ambient air particulate matter), using a plasmid relaxation assay where the extract caused single-strand breaks, ... -
The role of indoleamine 2,3-dioxygenase in renal tubular epithelial cells senescence under anoxia or reoxygenation
(2021)Ischemia-reperfusion injury is the commonest form of acute kidney injury (AKI). Tubular epithelial cell senescence contributes to incomplete recovery from AKI and predisposes to subsequent chronic kidney disease. In cultures ... -
Unraveling the mechanisms of extreme radioresistance in prokaryotes: Lessons from nature
(2016)The last 50 years, a variety of archaea and bacteria able to withstand extremely high doses of ionizing radiation, have been discovered. Several lines of evidence suggest a variety of mechanisms explaining the extreme ...