Πλοήγηση ανά Θέμα "Brain Neoplasms"

Addressing the post-irradiation hypothalamic-pituitary endocrine abnormalities of brain tumors in pediatric patients

Velentza L., Tolia M., Christakou C., Nikolaou M., Zerdes I.-N., Tsoukalas N., Hajiioannou J., Tsanadis K., Rigas G., Mitsis M., Theodorou K., Pistevou-Gombaki K., Tsekeris P., Kyrgias G. (2017)

Purpose: Hypothalamic-pituitary axis is susceptible to radiotherapy, causing endocrine disorders to childhood cancer survivors. We conducted a systematic review in order to assess the radiation-induced toxicity that leads ...

Benign intracranial lesions-radiotherapy: An overview of treatment options, indications and therapeutic results

Tzikoulis V., Gkantaifi A., Alongi F., Tsoukalas N., Saraireh H.H., Charalampakis N., Tzikoulis G., Andreou E., Tsapakidis K., Kardamakis D., Tsanadis K., Kyrgias G., Tolia M. (2020)

Background: Radiation Therapy (RT) is an established treatment option for benign intracranial lesions. The aim of this study is to display an update on the role of RT concerning the most frequent benign brain lesions and ...

Combined anterior and posterior shoulder dislocation as a manifestation of a brain tumour

Tsionos, I.; Karahalios, T.; Zibis, A. H.; Malizos, K. N. (2004)

Seizures are sometimes the first manifestation of a brain tumour. They may give rise to shoulder fractures or fracture-dislocations. When bilateral, these lesions tend to be symmetrical. The patient reported here suffered ...

Dual IRE1 RNase functions dictate glioblastoma development

Lhomond S., Avril T., Dejeans N., Voutetakis K., Doultsinos D., McMahon M., Pineau R., Obacz J., Papadodima O., Jouan F., Bourien H., Logotheti M., Jégou G., Pallares-Lupon N., Schmit K., Le Reste P.-J., Etcheverry A., Mosser J., Barroso K., Vauléon E., Maurel M., Samali A., Patterson J.B., Pluquet O., Hetz C., Quillien V., Chatziioannou A., Chevet E. (2018)

Proteostasis imbalance is emerging as a major hallmark of cancer, driving tumor aggressiveness. Evidence suggests that the endoplasmic reticulum (ER), a major site for protein folding and quality control, plays a critical ...

Effect of single dose irradiation on human glioblastoma spheroids in vitro

Fehlauer, F.; Stalpers, L. J. A.; Panayiotides, J.; Kaaijk, P.; González Gonźalez, D.; Leenstra, S.; Van Der Valk, P.; Sminia, P. (2004)

Investigation of the predictive value of a radiosurgery-relevant treatment of glioblastoma spheroids. Organotypic multicellular spheroids were cultured and irradiated (20 Gy). Morphology, apoptosis and immunohistochemical ...

The expression of the epitope H recognized by the monoclonal antibody H is higher in astrocytomas compared to anaplastic astrocytomas and glioblastomas

Arvanitis, D. L.; Arvanitis, L. D.; Panourias, I. G.; Kitsoulis, P.; Kanavaros, P. (2005)

The epitope H contains an O-linked N-acetylglucosamine residue in a specific conformation and/or environment recognized by the monoclonal antibody H (mAbH). mAbH stains two bands with Mr x10-3 of 209 and 62 in lysates of ...

Focus on the use of resveratrol as an adjuvant in glioblastoma therapy

Dionigi L., Ragonese F., Monarca L., Covino S., de Luca A., Iannitti R.G., Bastioli F., Moulas A.N., Allegretti M., Fioretti B. (2020)

Glioblastoma (GB) represents the most common and malignant form of glioma cancer. The Gold Standard in Glioblastoma is neurosurgical tumor removal and radiotherapy treatment in concomitant with temo-zolomide (TMZ). ...

Glioblastoma Multiforme in a Patient with Celiac Disease: Management of Seizures After Gross Total Tumor Resection

Fotakopoulos G., Brotis A.G., Kotlia P., Fountas K. (2018)

Background: A 55-year-old woman with a history of celiac disease presented with focal seizures and a mass lesion located at the left frontal lobe. Management of seizures in these patients is challenging. Case Description: ...

High intratumoural accumulation of stealth® liposomal doxorubicin (Caelyx®) in glioblastomas and in metastatic brain tumours

Koukourakis, M. I.; Koukouraki, S.; Fezoulidis, I.; Kelekis, N.; Kyrias, G.; Archimandritis, S.; Karkavitsas, N. (2000)

The blood-brain barrier is a major obstacle for the chemotherapeutic drugs to effectively reach primary or secondary brain tumours, Stealth® liposomal drugs are highly accumulated in tumoural tissues. In the present study ...

Imaging biomarker analysis of advanced multiparametric MRI for glioma grading

Vamvakas A., Williams S.C., Theodorou K., Kapsalaki E., Fountas K., Kappas C., Vassiou K., Tsougos I. (2019)

Aims and objectives: To investigate the value of advanced multiparametric MR imaging biomarker analysis based on radiomic features and machine learning classification, in the non-invasive evaluation of tumor heterogeneity ...

Lapatinib with whole brain radiotherapy in patients with brain metastases from breast and non-small cell lung cancer: a phase II study of the Hellenic Cooperative Oncology Group (HeCOG)

Christodoulou C., Kalogera-Fountzila A., Karavasilis V., Kouvatseas G., Papandreou C.N., Samantas E., Varaki K., Papadopoulos G., Bobos M., Rallis G., Razis E., Goudopoulou A., Kalogeras K.T., Syrigos K.N., Fountzilas G. (2017)

Small molecules, mainly tyrosine kinase inhibitors, are currently used in various malignancies. Lapatinib, a dual inhibitor of EGFR/HER2 tyrosine kinases, has demonstrated effectiveness in brain metastases from HER2-overexpressing ...

Local intracerebral inhibition of IRE1 by MKC8866 sensitizes glioblastoma to irradiation/chemotherapy in vivo

Le Reste P.J., Pineau R., Voutetakis K., Samal J., Jégou G., Lhomond S., Gorman A.M., Samali A., Patterson J.B., Zeng Q., Pandit A., Aubry M., Soriano N., Etcheverry A., Chatziioannou A., Mosser J., Avril T., Chevet E. (2020)

Glioblastoma multiforme (GBM) is the most severe primary brain cancer. Despite an aggressive treatment comprising surgical resection and radio/chemotherapy, patient's survival post diagnosis remains short. A limitation for ...

Machine learning assisted DSC-MRI radiomics as a tool for glioma classification by grade and mutation status

Sudre C.H., Panovska-Griffiths J., Sanverdi E., Brandner S., Katsaros V.K., Stranjalis G., Pizzini F.B., Ghimenton C., Surlan-Popovic K., Avsenik J., Spampinato M.V., Nigro M., Chatterjee A.R., Attye A., Grand S., Krainik A., Anzalone N., Conte G.M., Romeo V., Ugga L., Elefante A., Ciceri E.F., Guadagno E., Kapsalaki E., Roettger D., Gonzalez J., Boutelier T., Cardoso M.J., Bisdas S. (2020)

Background: Combining MRI techniques with machine learning methodology is rapidly gaining attention as a promising method for staging of brain gliomas. This study assesses the diagnostic value of such a framework applied ...