Πλοήγηση ανά Θέμα "5' untranslated region"
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Detection of negative and positive RNA strand of poliovirus Sabin 1 and echovirus E19 by a stem-loop reverse transcription PCR
(2017)In this report a strand specific RT-PCR was established for the detection of the replicative negative RNA strand of poliovirus sabin 1 (Sabin1) and Echovirus 19 (E19) strains. The key for the successful conduction of the ... -
Development of a novel PTD-mediated IVT-mRNA delivery platform for potential protein replacement therapy of metabolic/genetic disorders
(2021)The potential clinical applications of the powerful in vitro-transcribed (IVT)-mRNAs, to restore defective protein functions, strongly depend on their successful intracellular delivery and transient translation through the ... -
Development of a reverse transcription loop-mediated isothermal amplification assay (RT-LAMP) that detects enteroviruses by targeting the highly conserved 5′-UTR region
(2020)Enteroviruses are positive sense single-stranded RNA viruses. Most infections from enteroviruses are asymptomatic and can circulate “silently”, increasing the risk of an outbreak. For preventing such outbreaks, a rapid, ... -
International Consensus on the Use of Genetics in the Management of Hereditary Angioedema
(2020)Hereditary angioedema (HAE) is becoming much more genetically complex than was initially considered. Thus, the role of HAE genetics is expanding beyond research laboratories, and the genotyping of subjects suffering from ... -
Intra- and inter-serotypic recombinations in the 5΄ UTR-VP4 region of Echovirus 30 strains
(2018)Recombination has been recognized as a major mechanism of evolution in enteroviruses. The Echovirus 30 (E-30) strain Gior was sequenced and phylogenetically compared to all available E-30 sequences to detect recombination ... -
Large-scale genomic analysis reveals recurrent patterns of intertypic recombination in human enteroviruses
(2019)Recombination is a driving force for the emergence, evolution and virulence/epidemics of viruses, comprising the Enterovirus genus of the Picornaviridae family, important for human and animal health. By analyzing 2949 ... -
WarmStart colorimetric RT-LAMP for the rapid, sensitive and specific detection of Enteroviruses A–D targeting the 5′UTR region
(2021)Aims: The aim of the present study was to develop a colorimetric LAMP assay for the detection of enteroviruses belonging to species A–D targeting the 5′ untranslated region (5′ UTR) of enteroviruses genome. Methods and ...