Πλοήγηση ανά Συγγραφέα "Siapati, E. K."
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AML Survival and In Vivo Progression Is Dependent On beta-Catenin Signaling
Siapati, E. K.; Papadaki, M.; Kozaou, Z.; Rouka, E.; Michali, E.; Gogos, D.; Savvidou, I.; Kyriakou, D. S.; Anagnostopoulos, N. L.; Vassilopoulos, G. (2009) -
Comparative analysis of FV vectors with human alpha- or beta-globin gene regulatory elements for the correction of beta-thalassemia
Morianos, I.; Siapati, E. K.; Pongas, G.; Vassilopoulos, G. (2012)beta-Globin locus control region (LCR) sequences have been widely used for the regulated expression of the human beta-globin gene in therapeutic viral vectors. In this study, we compare the expression of the human beta-globin ... -
Development of foamy virus vectors for the genetic correction of chronic granulomatous disease
Chatziandreou, I.; Siapati, E. K.; Vassilopoulos, G. (2008) -
Dual transgene expression by foamy virus vectors carrying an endogenous bidirectional promoter
Andrianaki, A.; Siapati, E. K.; Hirata, R. K.; Russell, D. W.; Vassilopoulos, G. (2010)Several gene therapy applications require the transfer and simultaneous expression of multiple genes in the same cell. In this study, we analyzed the potential for coordinated expression of an endogenous bidirectional ... -
A Foamy Virus Vector System for Stable and Efficient RNAi Expression in Mammalian Cells
Papadaki, M.; Siapati, E. K.; Vassilopoulos, G. (2011)The promise of the RNA interference (RNAi) technology is equally dependent on the efficiency and stability of gene silencing. The aim of the present study was the development of foamy virus (FV) vectors for stable RNAi, ... -
Genetic correction of X-linked chronic granulomatous disease with novel foamy virus vectors
Chatziandreou, I.; Siapati, E. K.; Vassilopoulos, G. (2011)Objective. The X-linked form of chronic granulomatous disease (X-CGD) results from mutations in the CYBB gene encoding gp91(phox), the larger subunit of the oxidase flavocytochrome b(558). Affected individuals suffer from ... -
Neuroblastoma cells negative for CD44 possess tumor-initiating properties
Siapati, E. K.; Rouka, E.; Kyriakou, D.; Vassilopoulos, G. (2011)CD44 has been linked to favorable prognosis in neuroblastoma and in the present study we investigate if it can be used to prospectively isolate neuroblastoma-initiating cells. To define the cancer-initiating properties of ... -
Proliferation and bone marrow engraftment of AML blasts is dependent on beta-catenin signalling
Siapati, E. K.; Papadaki, M.; Kozaou, Z.; Rouka, E.; Michali, E.; Savvidou, I.; Gogos, D.; Kyriakou, D.; Anagnostopoulos, N. I.; Vassilopoulos, G. (2011)P>B-catenin is the central effector molecule of the canonical Wnt signalling pathway, which controls self-renewal of haematopoietic stem cells. Deregulation of this pathway occurs in various malignancies including myeloid ...