Πλοήγηση ανά Συγγραφέα "Ritis, K."
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Analysis of SAA1 gene polymorphisms in the Greek population: rheumatoid arthritis and FMF patients relative to normal controls. Homogeneous distribution and low incidence of AA amyloidosis
Mavragani, C. P.; Yiannakouris, N.; Zintzaras, E.; Melistas, L.; Ritis, K.; Skopouli, F. N. (2007)Objective. To address whether or not the rarity of amyloidosis in Greek patients with rheumatoid arthritis (RA) is related to specific alleles of single nucleotide polymorphisms (SNPs) in the 5'-flanking region and the ... -
Endothelin-1 Signaling Promotes Fibrosis In Vitro in a Bronchopulmonary Dysplasia Model by Activating the Extrinsic Coagulation Cascade
Kambas, K.; Chrysanthopoulou, A.; Kourtzelis, I.; Skordala, M.; Mitroulis, I.; Rafail, S.; Vradelis, S.; Sigalas, I.; Wu, Y. Q.; Speletas, M.; Kolios, G.; Ritis, K. (2011)Neonatal respiratory distress syndrome can progress to bronchopulmonary dysplasia (BPD), a serious pulmonary fibrotic disorder. Given the involvement of the extrinsic coagulation cascade in animal models of lung fibrosis, ... -
Fast and reliable mutation detection of the complete exon 11-15 JAK2 coding region using non-isotopic RNase cleavage assay (NIRCA)
Kambas, K.; Mitroulis, I.; Kourtzelis, I.; Chrysanthopoulou, A.; Speletas, M.; Ritis, K. (2009)The screening for JAK2 V617F mutation in patients with polycythemia vera, essential thrombocythemia, and idiopathic myelofibrosis offers crucial information for the final diagnosis of these disorders. Recently, several ... -
Foxp3 Expression in Liver Correlates with the Degree but Not the Cause of Inflammation
Speletas, M.; Argentou, N.; Germanidis, G.; Vasiliadis, T.; Mantzoukis, K.; Patsiaoura, K.; Nikolaidis, P.; Karanikas, V.; Ritis, K.; Germenis, A. E. (2011)Patients with chronic viral hepatitis display increased expression of Foxp3 in liver, suggesting that Tregs expansion contributes to persistent infection. The purpose of this study was to elucidate whether the expression ... -
Genetic analysis of C5a receptors in neutrophils from patients with familial Mediterranean fever
Apostolidou, E.; Kambas, K.; Chrysanthopoulou, A.; Kourtzelis, I.; Speletas, M.; Ritis, K.; Mitroulis, I. (2012)Familial Mediterranean fever (FMF) is an autoinflammatory disease, characterized by MEFV gene mutations and self-limited recurrent episodes of fever and localized serositis. Complement system is a key regulator of the ... -
In vivo induction of the autophagic machinery in human bone marrow cells during Leishmania donovani complex infection
Mitroulis, I.; Kourtzelis, I.; Papadopoulos, V. P.; Mimidis, K.; Speletas, M.; Ritis, K. (2009)Autophagy is a homeostatic process promoting cell survival in periods of stress. The induction of the autophagic machinery has also been implicated in both innate and adaptive immunity. Leishmania donovani, which is the ... -
Leptin induces the expression of functional tissue factor in human neutrophils and peripheral blood mononuclear cells through JAK2-dependent mechanisms and TNF alpha involvement
Rafail, S.; Ritis, K.; Schaefer, K.; Kourtzelis, I.; Speletas, M.; Doumas, M.; Giaglis, S.; Kambas, K.; Konstantinides, S.; Kartalis, G. (2008)Introduction: Leptin is an adipocyte-derived cytokine primarily involved in the regulation of body weight and energy balance. In vivo studies suggest that leptin promotes platelet aggregation and thrombosis. Neutrophils ... -
LIVER PD-1/PDL-1/PD-L2 MRNA EXPRESSION QUANTITATIVE ANALYSIS IN PATIENTS WITH CHRONIC HBV AND HCV HEPATITIS
Argentou, N.; Germanidis, G.; Vassiliadis, T.; Patsiaura, K.; Mantzoukis, K.; Ritis, K.; Eleftheriadis, D.; Evgenidis, N.; Nikolaidis, P.; Germenis, A. E.; Speletas, M. (2010) -
MEFV alterations and population genetics analysis in a large cohort of Greek patients with familial Mediterranean fever
Giaglis, S.; Papadopoulos, V.; Kambas, K.; Doumas, M.; Tsironidou, V.; Rafail, S.; Kartalis, G.; Speletas, M.; Ritis, K. (2007)Familial Mediterranean fever (FMF) is a disease characterized by recurrent, self-limiting bouts of fever and serositis and caused by altered pyrin due to mutated MEFV gene. FMF is common in the Mediterranean Basin populations, ... -
Methylation status of RASSF1A in patients with chronic myeloid leukemia
Avramouli, A.; Tsochas, S.; Mandala, E.; Katodritou, E.; Ioannou, M.; Ritis, K.; Speletas, M. (2009)RASSF1A, a key cell cycle related gene, is expressed in all hematopoietic cells, it is implicated in ras signaling pathway and its promoter hypermethylation is observed in a wide variety of solid tumors. Till now, RASSF1A ... -
Regulation of the autophagic machinery in human neutrophils
Mitroulis, I.; Kourtzelis, I.; Kambas, K.; Rafail, S.; Chrysanthopoulou, A.; Speletas, M.; Ritis, K. (2010)The induction of the autophagy machinery, a process for the catabolism of cytosolic proteins and organelles, constitutes a crucial mechanism in innate immunity. However, the involvement of autophagy in human neutrophils ... -
Survivin isoform expression patterns in CML patients correlate with resistance to imatinib and progression, but do not trigger cytolytic responses
Speletas, M.; Argentou, N.; Karanikas, V.; Gramoustianou, E. S.; Mandala, E.; Braimi, M.; Matsouka, P.; Ritis, K.; Germenis, A. E. (2011)Tyrosine-kinase inhibitors are very effective in patients with CML, but in most cases the disease relapses after their discontinuation. As a result, novel approaches should be considered, such as anti-survivin treatment ... -
TLR single nucleotide polymorphisms (SNPs) distribution among familial mediterranean fever (FMF) patients and normal individuals
Speletas, M.; Kalala, F.; Papadopoulos, V. P.; Merentiti, V.; Mitroulis, I.; Ritis, K.; Germenis, A. E. (2009) -
TLR2 and TLR4 polymorphisms in familial Mediterranean fever
Speletas, M.; Kalala, F.; Mitroulis, I.; Papadopoulos, V.; Merentiti, V.; Germenis, A. E.; Ritis, K. (2009)It has been suggested that MEVF mutations offer advantage against infections, including tuberculosis. Bearing in mind the central role of TLR-2 and TLR-4 in the recognition of pathogens, we conducted this study to examine ... -
TLR4 single nucleotide polymorphisms and thrombosis risk in patients with myeloproliferative disorders
Speletas, M.; Liadaki, K.; Kalala, F.; Daiou, C.; Katodritou, E.; Mandala, E.; Korantzis, I.; Ritis, K.; Zintzaras, E.; Germenis, A. E. (2008)