Πλοήγηση ανά Συγγραφέα "Pitsikas N."
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Constituents of saffron (Crocus sativus L.) as potential candidates for the treatment of anxiety disorders and schizophrenia
Pitsikas N. (2016)Anxiety disorders and schizophrenia are common public health issues. The dried stigma of the plant Crocus sativus L., (C. sativus) commonly known as saffron are used in folk medicine for various purposes. Several lines of ... -
Crocus sativus L. extracts and its constituents crocins and safranal; Potential candidates for schizophrenia treatment?
Pitsikas N. (2021)Schizophrenia is a chronic mental devastating disease. Current therapy suffers from various limitations including low efficacy and serious side effects. Thus, there is an urgent necessity to develop new antipsychotics with ... -
The nicotinic α7 receptor agonist GTS-21 but not the nicotinic α4β2 receptor agonist ABT-418 attenuate the disrupting effects of anesthetic ketamine on recognition memory in rats
Pitsikas N. (2020)Several lines of evidence indicate that anesthetic doses of the non-competitive N-methyl-D-aspartate receptor antagonist ketamine disrupt memory functions in rodents. The mechanism by which anesthetic ketamine produces its ... -
The Role of Ketamine in Object Recognition Memory in Rodents
Pitsikas N. (2018)The object recognition test (ORT) was developed to assess the role of brain structures and neurochemical systems in memory processes in rodents, mainly rats and mice. It is based on spontaneous exploratory behaviour; hence ... -
The role of nitric oxide (NO) donors in anxiety. Lights and shadows
Pitsikas N. (2018)Anxiety-related disorders are a common public health issues. Current medication for this affective disorder involves the GABA-ergic or the serotonergic transmission. Different forms of anxiety, however, are resistant to ... -
The role of nitric oxide donors in schizophrenia: Basic studies and clinical applications
Pitsikas N. (2015)Schizophrenia is a complex and chronic mental health disease that affects nearly 1% of the population worldwide. While the current antipsychotic medications have profoundly impacted the treatment of schizophrenia over the ... -
The role of nitric oxide synthase inhibitors in schizophrenia
Pitsikas N. (2016)Close to 1% of the world population suffer from schizophrenia. Current medications for this chronic mental disorder have greatly improved treatment over the last half century or more, but, the newer atypical antipsychotics ...