Πλοήγηση ανά Συγγραφέα "Papasotiriou, I."

Anvirzel (TM) in combination with cisplatin in breast, colon, lung, prostate, melanoma and pancreatic cancer cell lines

Apostolou, P.; Toloudi, M.; Chatziioannou, M.; Ioannou, E.; Knocke, D. R.; Nester, J.; Komiotis, D.; Papasotiriou, I. (2013)

Background: Platinum derivatives are used widely for the treatment of many cancers. However, the toxicity that is observed makes imperative the need for new drugs, or new combinations. Anvirzel (TM) is an extract which has ...

Comparative Study of Nanog, Oct3/4 and Sox2 Gene Expression Following C-Met Gene Knockdown in Colon Cancer Stem Cells

Chatziioannou, M.; Apostolou, P.; Toloudi, M.; Ioannou, E.; Hammon, R.; Jacob, U.; Kopic, A.; Hembry, N.; Komiotis, D.; Papasotiriou, I. (2012)

Comparison of the Growth Curves of Cancer Cells and Cancer Stem Cells

Toloudi, M.; Ioannou, E.; Chatziioannou, M.; Apostolou, P.; Kiritsis, C.; Manta, S.; Komiotis, D.; Papasotiriou, I. (2014)

A fundamental problem in cancer research is identification of the cells responsible for tumor formation. The latest field of cancer research has revealed the existence and role of cancer stem cells (CSCs). These findings ...

Rapid microwave-enhanced synthesis of C5-alkynyl pyranonucleosides as novel cytotoxic antitumor agents

Dimopoulou, A.; Manta, S.; Kiritsis, C.; Gkaragkouni, D. N.; Papasotiriou, I.; Balzarini, J.; Komiotis, D. (2013)

A microwave-assisted, one-pot, coupling reaction for the synthesis of C5-alkynyl-uracil and cytosine glucopyranonucleosides has been developed. The reaction is carried out under standard Sonogashira coupling conditions ...

The role of AP-1 in colon cancer stem cells

Chatziioannou, M.; Apostolou, P.; Toloudi, M.; Ioannou, E.; Kopic, A.; Komiotis, D.; Papasotiriou, I. (2013)

STEREOCONTROLLED FACILE SYNTHESIS AND BIOLOGICAL EVALUATION OF (3 ' S) AND (3 ' R)-3 '-AMINO (AND AZIDO)-3 '-DEOXY PYRANONUCLEOSIDES

Manta, S.; Parmenopoulou, V.; Kiritsis, C.; Dimopoulou, A.; Kollatos, N.; Papasotiriou, I.; Balzarini, J.; Komiotis, D. (2012)

This article describes the synthesis of (3'S) and (3'R)-3'-amino-3'-deoxy pyranonucleosides and their precursors (3'S) and (3'R)-3'-azido-3'-deoxy pyranonucleosides. Azidation of 1,2:5,6-di-O-isopropylidene-3-O-toluenesu ...

Stereocontrolled synthesis of 4 '-C-cyano and 4 '-C-cyano-4 '-deoxy pyrimidine pyranonucleosides as potential chemotherapeutic agents

Kiritsis, C.; Manta, S.; Parmenopoulou, V.; Dimopoulou, A.; Kollatos, N.; Papasotiriou, I.; Balzarini, J.; Komiotis, D. (2012)

A new series of 4'-C-cyano and 4'-C-cyano-4'-deoxy pyrimidine pyranonucleosides has been designed and synthesized. Commercially available 1,2,3,4,6-penta-O-acetyl-D-mannopyranose (1) was condensed with silylated 5-fluorouracil, ...

Study of the interaction among Notch pathway receptors, correlation with stemness, as well as their interaction with CD44, dipeptidyl peptidase-IV, hepatocyte growth factor receptor and the SETMAR transferase, in colon cancer stem cells

Apostolou, P.; Toloudi, M.; Ioannou, E.; Kourtidou, E.; Chatziioannou, M.; Kopic, A.; Komiotis, D.; Kiritsis, C.; Manta, S.; Papasotiriou, I. (2013)

Context: The Notch signaling pathway is one of the most important pathways during normal development and implicated in self-renewal of adult stem cells and differentiation of progenitor cells. Abnormal expression of Notch ...

Synthesis and Biological Evaluation of 3 '-C-Ethynyl and 3 '-C-(1,4-disubstituted-1,2,3-triazolo) Double-Headed Pyranonucleosides

Kiritsis, C.; Manta, S.; Papasotiriou, I.; Coutouli-Argyropoulou, E.; Trakossas, S.; Balzarini, J.; Komiotis, D. (2012)

A novel series of 3'-C-ethynyl and 3'-C-(1,4-disubstituted-1,2,3-triazolo) double-headed pyranonucleosides has been designed and synthesized. Reaction of 3-keto glucoside 1 with ethynyl magnesium bromide gave the desired ...

Synthesis and biological evaluation of 3′-c-ethynyl and 3′-c-(1,4-disubstituted-1,2,3-triazolo) double-headed pyranonucleosides

Kiritsis, C.; Manta, S.; Papasotiriou, I.; Coutouli-Argyropoulou, E.; Trakossas, S.; Balzarini, J.; Komiotis, D. (2012)

A novel series of 3′-C-ethynyl and 3′-C-(1,4-disubstituted-1,2, 3-triazolo) double-headed pyranonucleosides has been designed and synthesized. Reaction of 3-keto glucoside 1 with ethynyl magnesium bromide gave the desired ...