Πλοήγηση ανά Συγγραφέα "Moraitis, D."
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Activation of mTOR signaling in medullary and aggressive papillary thyroid carcinomas
Kouvaraki, M. A.; Liakou, C.; Paraschi, A.; Dimas, K.; Patsouris, E.; Tseleni-Balafouta, S.; Rassidakis, G. Z.; Moraitis, D. (2011)Background. Because mammalian target of rapamycin (mTOR) may be involved in thyroid carcinogenesis, we investigated the expression and activation patterns of mTOR signaling proteins in thyroid carcinoma cells and tumors ... -
SIN1, a critical component of the mTOR-Rictor complex, is overexpressed and associated with AKT activation in medullary and aggressive papillary thyroid carcinomas
Moraitis, D.; Karanikou, M.; Liakou, C.; Dimas, K.; Tzimas, G.; Tseleni-Balafouta, S.; Patsouris, E.; Rassidakis, G. Z.; Kouvaraki, M. A. (2014)Background. Mammalian target of rapamycin (mTOR) forms 2 active complexes in the cell: the rapamycin-sensitive mTOR-Raptor (mTORC1) and the rapamycin-insensitive mTOR-Rictor (mTORC2). The latter activates AKT kinase, which ...