Auflistung nach Autor "Koukourakis, M. I."
Anzeige der Dokumente 1-20 von 20
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Angiogenesis and apoptosis-related protein (p53, bcl-2, and bax) expression versus response of gastric adenocarcinomas to paclitaxel and carboplatin chemotherapy
Giatromanolaki, A.; Stathopoulos, G. P.; Koukourakis, M. I.; Rigatos, S.; Vrettou, E.; Kittas, C.; Fountzilas, G.; Sivridis, E. (2001)The role of angiogenesis and apoptosis-related proteins in defining response to chemotherapy is poorly understood. We examined the microvessel density (MVD) and the expression of p53, bcl-2, and bax proteins in a series ... -
Angiogenesis, thymidine phosphorylase, and resistance of squamous cell head and neck cancer to cytotoxic and radiation therapy
Koukourakis, M. I.; Giatromanolaki, A.; Fountzilas, G.; Sivridis, E.; Gatter, K. C.; Harris, A. L. (2000)Thymidine phosphorylase (TP), an enzyme involved in the thymidine synthesis and degradation, has been shown to promote tumor angiogenesis, Both TP expression and tumor vascularization are putative postoperative prognostic ... -
Angiogenic interactions of vascular endothelial growth factor, of thymidine phosphorylase, and of p53 protein expression in locally advanced gastric cancer
Giatromanolaki, A.; Koukourakis, M. I.; Stathopoulos, G. P.; Kapsoritakis, A.; Paspatis, G.; Kakolyris, S.; Sivridis, E.; Georgoulias, V.; Harris, A. L.; Gatter, K. C. (2000)The assessment of the angiogenic profile of tumors may become an important tool as a guide for the inclusion of novel drugs and molecular therapies into the standard chemoradiotherapy policy. Several studies have shown the ... -
The angiogenic pathway 'vascular endothelial growth factor/flk-I (KDR)-receptor' in rheumatoid arthritis and osteoarthritis
Giatromanolaki, A.; Sivridis, E.; Atanassou, N.; Zois, E.; Thorpe, P. E.; Brekken, R. A.; Gatter, K. C.; Harris, A. L.; Koukourakis, I. M.; Koukourakis, M. I. (2001)Active angiogenesis, together with an up-regulation of angiogenic factors, is evident in the synovium of both rheumatoid arthritis (RA) and osteoarthritis (OA). The present study assessed, by immunohistochemistry, the ... -
Bax protein expression in colorectal cancer: Association with p53, bcl-2 and patterns of relapse
Giatromanolaki, A.; Sivridis, E.; Stathopoulos, G. P.; Fountzilas, G.; Kalofonos, H. P.; Tsamandas, A.; Vrettou, E.; Scopa, C.; Polychronidis, A.; Simopoulos, K.; Koukourakis, M. I. (2001)This study evaluated the frequency and the prognostic significance of bax, bcl-2 and p53 proteins in stage B and C adenocarcinomas of the colon and rectum. Paraffin-embedded specimens from 268 patients with colorectal ... -
bcl-2 and c-erbB-2 proteins are involved in the regulation of VEGF and of thymidine phosphorylase angiogenic activity in non-small-cell lung cancer
Koukourakis, M. I.; Giatromanolaki, A.; O'Byrne, K. J.; Cox, J.; Krammer, B.; Gatter, K. C.; Harris, A. L. (1999)Tumour angiogenesis has been recently recognised as one of the most important prognostic factors in lung cancer. Although a variety of angiogenic factors have been identified, the angiogenesis process remains poorly ... -
Cancer vascularization: Implications in radiotherapy?
Koukourakis, M. I.; Giatromanolaki, A.; Sivridis, E.; Fezoulidis, I. (2000)Purpose: Although hypoxia is considered a major cause of failure of radiotherapy, the mechanisms of tumor hypoxia are unclear, and effective ways for its correction or targeting are missing. Tumoral vasculature is the ... -
Clarification on the potential of subcutaneous ethyol as a radioprotective agent - Reply
Koukourakis, M. I. (2001) -
Clinical and experimental evidence of bcl-2 involvement in the response to photodynamic therapy
Koukourakis, M. I.; Corti, L.; Skarlatos, J.; Giatromanolaki, A.; Krammer, B.; Blandamura, S.; Piazza, M.; Verwanger, T.; Schnitzhofer, G.; Kostandelos, J.; Beroukas, K. (2001)Purpose: The role of apoptosis related proteins in the response of human malignancies to photodynamic therapy (PDT) is under investigation. The aim of the study was to examine the role of p53 and of bcl-2 protein expression ... -
Coexpression of MUC1 glycoprotein with multiple angiogenic factors in non-small cell lung cancer suggests coactivation of angiogenic and migration pathways
Giatromanolaki, A.; Koukourakis, M. I.; Sivridis, E.; O'Byrne, K.; Cox, G.; Thorpe, P. E.; Gatter, K. C.; Harris, A. L. (2000)We investigated the expression of MUC1 protein and its relationship to the microvessel density and the expression of thymidine phosphorylase, vascular endothelial growth factor (VEGF), VEGF-receptor KDR, basic fibroblast ... -
Concurrent administration of liposomal doxorubicin improves the survival of patients with invasive bladder cancer undergoing hypofractionated accelerated radiotherapy (HypoARC)
Panteliadou, M.; Touloupidis, S.; Giatromanolaki, A.; Pistevou, K.; Kyrgias, G.; Tsoutsou, P.; Kalaitzis, C.; Koukourakis, M. I. (2011)Cisplatin-based radio-chemotherapy is an effective alternative to cystectomy. The position of cisplatin has been challenged by novel drugs, while altered radiotherapy fractionation is also tested against conventional ... -
Dose Escalation of Amifostine for Radioprotection During Pelvic Accelerated Radiotherapy
Koukourakis, M. I.; Kyrgias, G.; Panteliadou, M.; Papadopoulou, A.; Tsiarkatsi, M.; Papachristou, E.; Bebeli, M. (2013)Objectives: Experimental data suggest a dose-dependent efficacy of amifostine so that the low overall doses used in clinical trials may have masked the full potential of the drug. In this study, we report our experience ... -
High intratumoural accumulation of stealth (R) liposomal doxorubicin (Caelyx (R)) in glioblastomas and in metastatic brain tumours
Koukourakis, M. I.; Koukouraki, S.; Fezoulidis, I.; Kelekis, N.; Kyrias, G.; Archimandritis, S.; Karkavitsas, N. (2000)The blood-brain barrier is a major obstacle for the chemotherapeutic drugs to effectively reach primary or secondary brain tumours. Stealth(R) liposomal drugs are highly accumulated in tumoural tissues. In the present study ... -
High intratumoural accumulation of stealth® liposomal doxorubicin (Caelyx®) in glioblastomas and in metastatic brain tumours
Koukourakis, M. I.; Koukouraki, S.; Fezoulidis, I.; Kelekis, N.; Kyrias, G.; Archimandritis, S.; Karkavitsas, N. (2000)The blood-brain barrier is a major obstacle for the chemotherapeutic drugs to effectively reach primary or secondary brain tumours, Stealth® liposomal drugs are highly accumulated in tumoural tissues. In the present study ... -
Hypoxia inducible factor (HIF-1a and HIF-2a) expression in early esophageal cancer and response to photodynamic therapy and radiotherapy
Koukourakis, M. I.; Giatromanolaki, A.; Skarlatos, J.; Corti, L.; Blandamura, S.; Piazza, M.; Gatter, K. C.; Harris, A. L. (2001)Hypoxia inducible factor 1a and 2a (HIF-1a and HIF-2a) are key proteins regulating cellular response to hypoxia, Because the efficacy of photodynamic therapy (PDT) is dependent on the presence of oxygen, the assessment of ... -
'Invading edge vs. inner' (edvin) patterns of vascularization: an interplay between angiogenic and vascular survival factors defines the clinical behaviour of non-small cell lung cancer
Giatromanolaki, A.; Koukourakis, M. I.; Sivridis, E.; O'Byrne, K.; Gatter, K. C.; Harris, A. L. (2000)Neo-angiogenesis during neoplastic growth involves endothelial mitogenic and migration stimuli produced by cancer or tumour stromal cells. Although this active angiogenesis takes place in the tumour periphery, the process ... -
Prognostic role of angiogenesis in operable carcinoma of the gallbladder
Giatromanolaki, A.; Sivridis, E.; Koukourakis, M. I.; Polychronidis, A.; Simopoulos, C. (2002)The prognostic significance of intratumoral angiogenesis was investigated in 62 patients with stage I-III carcinomas of the gallbladder treated with simple cholecystectomy. Microvessel density (MVD) was assessed ... -
Treatment of Low-risk Prostate Cancer with Radical Hypofractionated Accelerated Radiotherapy with Cytoprotection (HypoARC): An Interim Analysis of Toxicity and Efficacy
Koukourakis, M. I.; Kyrgias, G.; Papadopoulou, A.; Panteliadou, M.; Giatromanolaki, A.; Sivridis, E.; Mavropoulou, S.; Kalogeris, K.; Nassos, P.; Milioudis, N.; Touloupidis, S. (2011)Aim: Radiobiological analysis of clinical data suggests that prostate cancer has a low alpha/beta ratio, implying that large radiotherapy fractions may better control the disease. Acceleration of radiotherapy may be also ... -
Tumor angiogenesis is associated with MUC1 overexpression and loss of prostate-specific antigen expression in prostate cancer
Papadopoulos, I.; Sivridis, E.; Giatromanolaki, A.; Koukourakis, M. I. (2001)The biological potential of prostate cancer is highly variable and cannot be satisfactorily predicted by histopathological criteria alone. Therefore, additional and more precise information is desirable. Although angiogenesis ...