Listar por autor "Kalousi, A."

An Association Study between Hypoxia Inducible Factor-1alpha (HIF-1 alpha) Polymorphisms and Osteonecrosis

Chachami, G.; Kalousi, A.; Papatheodorou, L.; Lyberopoulou, A.; Nasikas, V.; Tanimoto, K.; Simos, G.; Malizos, K. N.; Georgatsou, E. (2013)

Bone hypoxia resulting from impaired blood flow is the final pathway for the development of osteonecrosis (ON). The aim of this study was to evaluate if HIF-1 alpha, the major transcription factor triggered by hypoxia, is ...

Casein kinase 1 regulates human hypoxia inducible factor HIF-1

Kalousi, A.; Mylonis, I.; Politou, A. S.; Chachami, G.; Paraskeva, E.; Simos, G. (2010)

Casein kinase 1 regulates human hypoxia-inducible factor HIF-1

Kalousi, A.; Mylonis, I.; Politou, A. S.; Chachami, G.; Paraskeva, E.; Simos, G. (2010)

Hypoxia-inducible factor 1 (HIF-1), a transcriptional activator that mediates cellular response to hypoxia and a promising target of anticancer therapy, is essential for adaptation to low oxygen conditions, embryogenesis ...

Identification of MAPK phosphorylation sites and their role in the localization and activity of hypoxia-inducible factor-1α

Mylonis, I.; Chachami, G.; Samiotaki, M.; Panayotou, G.; Paraskeva, E.; Kalousi, A.; Georgatsou, E.; Bonanou, S.; Simos, G. (2006)

Hypoxia-inducible factor 1 (HIF-1) controls the expression of most genes induced by hypoxic conditions. Regulation of expression and activity of its inducible subunit, HIF-1α, involves several post-translational modifications. ...

MgcRacGAP, a cytoskeleton regulator, inhibits HIF-1 transcriptional activity by blocking its dimerization

Lyberopoulou, A.; Mylonis, I.; Papachristos, G.; Sagris, D.; Kalousi, A.; Befani, C.; Liakos, P.; Simos, G.; Georgatsou, E. (2013)

Hypoxia inducible factor-1 (HIF-1), a dimeric transcription factor of the bHLH-PAS family, is comprised of HIF-1 alpha, which is inducible by hypoxia and ARNT or HIF-1 beta, which is constitutively expressed. HIF-1 is ...

Oxygen-dependent secretion of a bioactive hepcidin-GFP chimera

Chachami, G.; Lyberopoulou, A.; Kalousi, A.; Paraskeva, E.; Pantopoulos, K.; Simos, G. (2013)

Hepcidin, a hepatic hormone, regulates serum iron levels by controlling both intestinal iron absorption and iron release from macrophages. Although transcription of hepcidin is controlled by diverse stimuli, it remains ...

Phosphorylation of the N-terminal domain of the human HIF-1 alpha

Kalousi, A.; Mylonis, I.; Simos, G. (2008)

Reconstitution of human hypoxia inducible factor HIF-1 in yeast: A simple in vivo system to identify and characterize HIF-1 alpha effectors

Braliou, G. G.; Venieris, E.; Kalousi, A.; Simos, G. (2006)

Hypoxia inducible factor I (HIF-1), the master regulator of hypoxia-activated genes, is involved in many diseases and is a valid drug target. In order to develop a simple and genetically tractable in vivo system for HIF-1 ...