Πλοήγηση ανά Συγγραφέα "Grigoroudis, A. I."
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Dimerization of the AtoC response regulator and modelling of its binding to DNA
Papadopoulos, G.; Grigoroudis, A. I.; Kyriakidis, D. A. (2010)Bacterial signal transduction systems can be viewed as an entity of multi-sensory and output domains, whereas the functions of response regulators play a pivotal role in the complex network interactions. One crucial property ... -
Efficient soluble expression of active recombinant human cyclin A2 mediated by E. coli molecular chaperones
Grigoroudis, A. I.; McInnes, C.; Premnath, P. N.; Kontopidis, G. (2015)Bacterial expression of human proteins continues to present a critical challenge in protein crystallography and drug design. While human cyclin A constructs have been extensively characterized in complex with cyclin dependent ... -
Identification of additional Escherichia coli AtoC binding target elements gives new insight to bacterial regulatory networks: molecular modeling of AtoC-DNA binding domain amino acids
Grigoroudis, A. I.; Panagiotidis, C. A.; Pilalis, E.; Chatziioannou, A.; Kolisis, F.; Georgios, P.; Kyriakidis, D. A. (2009) -
Iterative Conversion of Cyclin Binding Groove Peptides into Drug like CDK Inhibitors with Antitumor Activity
Premnath, P. N.; Craig, S. N.; Liu, S.; Anderson, E. L.; Grigoroudis, A. I.; Kontopidis, G.; Perkins, T. L.; Wyatt, M. D.; Pittman, D. L.; McInnes, C. (2015)The cyclin groove is an important recognition site for substrates of the cell cycle cyclin dependent kinases and provides an opportunity for highly selective inhibition of kinase activity through a non-ATP competitive ... -
Quantification of the Effects of Ionic Strength, Viscosity, and Hydrophobicity on Protein-Ligand Binding Affinity
Papaneophytou, C. P.; Grigoroudis, A. I.; McInnes, C.; Kontopidis, G. (2014)In order to quantify the interactions between molecules of biological interest, the determination of the dissociation constant (K-d) is essential. Estimation of the binding affinity in this way is routinely performed in ...