Πλοήγηση ανά Συγγραφέα "Drainas, D."

A 40.7 kDa Rpp30/Rpp1 homologue is a protein subunit of Dictyostelium discoideum RNase P holoenzyme

Vourekas, A.; Kalavrizioti, D.; Zarkadis, I. K.; Spyroulias, G. A.; Stathopoulos, C.; Drainas, D. (2007)

RNase P is an essential and ubiquitous endonuclease that mediates the maturation of the 5' ends of all precursor tRNA molecules. The holoenzyme from Dictyostelium discoideum possesses RNA and protein subunits essential for ...

Composition of the ribonucleoprotein complex of ribonuclease P from Dictyostelium discoideurn

Vourekas, A.; Kalavrizioti, D.; Theodorakopoulou, O.; Stamatopoulou, V.; Toumpeki, C.; Stathopoulos, C.; Drainas, D. (2006)

Kinetics of inhibition of ribonuclease P activity by peptidyltransferase inhibitors: Effect of antibiotics on RNase P

Kalavrizioti, D.; Vourekas, A.; Tekos, A.; Tsagla, A.; Stathopoulos, C.; Drainas, D. (2003)

A cell-free system derived from Dictyostelium discoideum has been used to study the kinetics of inhibition of RNase P by puromycin, amicetin and blasticidin S. Detailed kinetic analysis showed that the type of inhibition ...

Modulation of catalytic RNA biological activity by small molecule effectors

Vourekas, A.; Kalavrizioti, D.; Stathopoulos, C.; Drainas, D. (2006)

Catalytic RNAs, known as ribozymes, act as true enzymes and are implicated in important biological processes, such as protein synthesis, mRNA splicing, transcriptional regulation and retroviral replication. Ribozymes are ...

The RNA component of ribonuclease P from Dictyostelium discoideum

Vourekas, A.; Stamatopoulou, V.; Stathopoulos, C.; Drainas, D. (2008)

RNA-Mediated therapeutics: From gene inactivation to clinical application

Kalavrizioti, D.; Vourekas, A.; Stamatopoulou, V.; Toumpeki, C.; Giannouli, S.; Stathopoulos, C.; Drainas, D. (2006)

The specific targeting and inactivation of gene expression represents nowdays the goal of the mainstream basic and applied biomedical research. Both researchers and pharmaceutical companies, taking advantage of the vast ...

RNase P: A promising molecular target for the development of new drugs

Tekos, A.; Stathopoulos, C.; Tsambaos, D.; Drainas, D. (2004)

RNase P is an ubiquitous and essential endonuclease in tRNA biogenesis, which generates the mature 5′-termini of tRNAs. RNase P activities have been identified in all three kingdoms of life (Bacteria, Archaea, Eukarya). ...