Πλοήγηση ανά Συγγραφέα "Alevizopoulos, K."
-
The labdane diterpene sclareol (labd-14-ene-8, 13-diol) induces apoptosis in human tumor cell lines and suppression of tumor growth in vivo via a p53-independent mechanism of action
Mahaira, L. G.; Tsimplouli, C.; Sakellaridis, N.; Alevizopoulos, K.; Demetzos, C.; Han, Z.; Pantazis, P.; Dimas, K. (2011)The labdane diterpene sclareol has demonstrated significant cytotoxicity against human tumor cell lines and human colon cancer xenografts. Therefore, there is need to elucidate the mode of action of this compound as very ... -
Steroidal Cardiac Na+/K (+) ATPase Inhibitors Exhibit Strong Anti-Cancer Potential in vitro and in Prostate and Lung Cancer Xenografts in vivo
Dimas, K.; Papadopoulou, N.; Baskakis, C.; Prousis, K. C.; Tsakos, M.; Alkahtani, S.; Honisch, S.; Lang, F.; Calogeropoulou, T.; Alevizopoulos, K.; Stournaras, C. (2014)Sodium potassium pump (Na+/K+ ATPase) is a validated pharmacological target for the treatment of congestive heart failure. Recent data with inotropic drugs such as digoxin & digitoxin (digitalis) suggest a potent anti-cancer ... -
A Steroidal Na+/K+ ATPase Inhibitor Triggers Pro-apoptotic Signaling and Induces Apoptosis in Prostate and Lung Tumor Cells
Honisch, S.; Alkahtani, S.; Kounenidakis, M.; Liu, G. L.; Alarifi, S.; Al-Yahya, H.; Dimas, K.; AlKahtane, A. A.; Prousis, K. C.; Al-Dahmash, B.; Calogeropoulou, T.; Alevizopoulos, K.; Lang, F.; Stournaras, C. (2014)Recently we have reported potent anti-cancer actions of various steroidal Na+/K+ ATPase inhibitors in multiple cell lines. Furthermore, the most powerful compound identified in this study, the 3-[(R)-3-pyrrolidinyl]oxime ...