Πλοήγηση ανά Θέμα "SUSCEPTIBILITY"
Αποτελέσματα 21-40 από 53
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Field Synopsis and Synthesis of Genetic Association Studies in Osteoarthritis: The CUMAGAS-OSTEO Information System
(2010)A comprehensive and systematic assessment of the current status of genetic association studies (GAS) for osteoarthntis was conducted. Data from 327 GAS involving 187 distinct genetic variants were analyzed and cataloged ... -
Genetic polymorphisms in the UDP-glucuronosyltransferase 1A1 (UGT1A1) gene and prostate cancer risk in Caucasian men
(2010)Background: Catechol-estrogen metabolites can induce carcinogenesis by acting as endogenous tumor initiators. Glucuronidation, mediated by the UDP-glucuronosyltransferase 1A1 (UGT1A1) enzyme, is a main metabolic pathway ... -
Genetic polymorphisms of innate and adaptive immunity as predictors of outcome in critically ill patients
(2015)Sepsis and septic shock frequently cause the admission or complicate the clinical course of critically ill patients admitted in the intensive care units (ICU). Genetic variations disrupting the immune sensing of infectious ... -
Genetic variants of homocysteine/folate metabolism pathway and risk of inflammatory bowel disease: a synopsis and meta-analysis of genetic association studies
(2010)A synopsis and meta-analysis of studies that investigated the association between genetic variants involved in the homocysteine/folate metabolism pathway and risk of inflammatory bowel disease (IBD) were conducted. Four ... -
Genome-wide association studies: hypothesis-"free" or "engaged"?
(2009)The advent of the first wave of genome-wide association studies (GWAS) provided a new conceptual framework in the search for variants underlying common disorders: a massive scan of the genome, free from underlying assumptions ... -
Genomic Convergence of Genome-wide Investigations for Complex Traits
(2009)Genome-wide investigations for identifying the genes for complex traits are considered to be agnostic in terms of prior assumptions for the responsible DNA alterations. The agreement of genome-wide association studies ... -
The growth differentiation factor 5 (GDF5) core promoter polymorphism is not associated with knee osteoarthritis in the Greek population
(2008)Genetic factors have been shown to play an important role in the etiology of osteoarthritis (OA). A functional single nucleotide polymorphism (SNP) +104T/C; rs143383 in the 5' UTR of the GDF5 gene was recently associated ... -
Identification of chromosomal regions linked to premature myocardial infarction: a meta-analysis of whole-genome searches
(2006)Myocardial infarction (MI) is a complication of coronary artery disease and the leading cause of death in the Western world. MI is considered a distinct phenotype with an increased genetic component for its premature type. ... -
Increasing prevalence of high-level gentamicin resistance among enterococci isolated in Greece
(2001)High-level gentamicin-resistant enterococci (HLGRE) (MIC >512 mug/ml) were frequently recovered in the AHEPA University Hospital, Thessaloniki, Greece, during a 15-month period (67/158, 42.4%). PCR testing showed that ... -
Influence of Commodity Type, Percentage of Cracked Kernels, and Wheat Class on Population Growth of Stored-Product Psocids (Psocoptera: Liposcelidae)
(2010)Differences in stored-product psocid progeny production as a function of commodity type, percentage of cracked kernels, and wheat class were examined using laboratory bioassays. Population growth of Liposcelis bostrychophila ... -
Interleukin-1B and interleukin-1 receptor antagonist gene polymorphisms in Greek multiple sclerosis (MS) patients with bout-onset MS
(2010)We investigated the association of specific polymorphisms of the interleukin IL-1b (AvaI -511 and TaqI +3,953) and IL-1 receptor antagonist (IL-1RN) (a variable number of tandem repeats; VNTR) genes with both the susceptibility ... -
Is minocycline a solution for multidrugresistant Acinetobacter baumannii?
(2014)Minocycline is an old, safe, second-line antimicrobial agent that has drawn attention over the last fewyears as a possible therapeutic option against multidrug-resistant Acinetobacter baumannii (MDRAB) clinical isolates. ... -
Large-Scale Analysis of Association Between GDF5 and FRZB Variants and Osteoarthritis of the Hip, Knee, and Hand
(2009)Objective. GDF5 and FRZB have been proposed as genetic loci conferring susceptibility to osteoarthritis (OA); however, the results of several studies investigating the association of OA with the rs143383 polymorphism of ... -
A large-scale replication study for the association of rs17039192 in HIF-2 alpha with knee osteoarthritis
(2012)Osteoarthritis (OA) is a common disease with a genetic component for its etiology. Recently, a genetic association of a single nucleotide polymorphism (SNP), rs17039192 in HIF-2a with knee OA has been reported in a Japanese ... -
Lesser grain borers, Rhyzopertha dominica, select rough rice kernels with cracked hulls for reproduction
(2012)Tests were conducted to determine whether the lesser grain borer, Rhyzopertha dominica (F.) (Coleoptera: Bostrychidae), selects rough rice (Oryza sativa L. (Poales: Poaceae)) kernels with cracked hulls for reproduction ... -
Maternal gene polymorphisms involved in folate metabolism and risk of Down syndrome offspring: a meta-analysis
(2007)Studies investigating the association between gene polymorphisms involved in homocysteine/folate metabolism and Down syndrome (DS) have reported contradictory or inconclusive results. A meta-analysis of 11 case-control ... -
Meningitis registry of hospitalized cases in children: epidemiological patterns of acute bacterial meningitis throughout a 32-year period
(2007)Background: Bacterial meningitis remains a source of substantial morbidity and mortality in childhood. During the last decades gradual changes have been observed in the epidemiology of bacterial meningitis, related to the ... -
Meta-analysis of association between the ASPN D-repeat and osteoarthritis
(2007)Osteoarthritis (OA) is the most common form of human arthritis. Genetic factors have been implicated in OA. It was reported that an aspartic acid (D)-repeat polymorphism in the gene encoding asporin (ASPN) was associated ... -
A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip
(2014)Objectives Osteoarthritis (OA) is the most common form of arthritis with a clear genetic component. To identify novel loci associated with hip OA we performed a meta-analysis of genome-wide association studies (GWAS) on ... -
A meta-analysis of genotypes and haplotypes of methylenetetrahydrofolate reductase gene polymorphisms in acute lymphoblastic leukemia
(2006)A meta-analysis of case-control studies that investigated the association between the C677T and/or A1298C polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene and acute lymphoblastic leukemia (ALL) was ...