Πλοήγηση ανά Θέμα "POLYMORPHISMS"
Αποτελέσματα 21-32 από 32
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Meta-analysis of association between the ASPN D-repeat and osteoarthritis
(2007)Osteoarthritis (OA) is the most common form of human arthritis. Genetic factors have been implicated in OA. It was reported that an aspartic acid (D)-repeat polymorphism in the gene encoding asporin (ASPN) was associated ... -
Novel Sequence Variations in the CER1 Gene Are Strongly Associated with Low Bone Mineral Density and Risk of Osteoporotic Fracture in Postmenopausal Women
(2012)Osteoporosis is a common skeletal disease characterized by a combination of low bone mass and increased fragility. In this case-control study, we investigated the possible association of two novel candidate genes, CER1 and ... -
The role of MTHFR gene in multiple myeloma
(2008)Case-control studies investigating associations between multiple myeloma (MM) and the C677T and A1298C polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) have provided controversial results. In an attempt to ... -
The Role of TLR4 896 A > G and 1196 C > T in Susceptibility to Infections: A Review and Meta-Analysis of Genetic Association Studies
(2013)Background: Toll-like receptor 4 plays a role in pathogen recognition, and common polymorphisms may alter host susceptibility to infectious diseases. Purpose: To review the association of two common polymorphisms (TLR4 ... -
Sleep-disordered breathing and blood pressure in children - A meta-analysis
(2007)Objectives: To estimate the risk of elevated blood pressure (BP) in children with obstructive sleep-disordered breathing (SDB) and to explore heterogeneity among published studies. Data Source: PubMed database. Study ... -
Synopsis and Data Synthesis of Genetic Association Studies in Hypertension for the Adrenergic Receptor Family Genes: The CUMAGAS-HYPERT Database
(2010)BACKGROUND The adrenergic receptor (adrenoceptor) family genes have been extensively studied as candidate genes in hypertension but the results of individual genetic association studies (GAS) are controversial and inconclusive ... -
Synopsis and meta-analysis of genetic association studies in osteoporosis for the focal adhesion family genes: the CUMAGAS-OSTEOporosis information system
(2011)Background: Focal adhesion (FA) family genes have been studied as candidate genes for osteoporosis, but the results of genetic association studies (GASs) are controversial. To clarify these data, a systematic assessment ... -
Synthesis of genetic association studies for pertinent gene-disease associations requires appropriate methodological and statistical approaches
(2008)Objective: The aim of the study was to consider statistical and methodological issues affecting the results of meta-analysis of genetic association studies for pertinent gene-disease associations. Although the basic ... -
Testing the druggable endothelial differentiation gene 2 knee osteoarthritis genetic factor for replication in a wide range of sample collections
(2009)Objectives: To replicate a previously reported association with osteoarthritis (OA) of the promoter single nucleotide polymorphism (SNP) rs10980705 in the endothelial differentiation gene 2 (EDG2). Methods: Five collections ... -
Trends in meta-analysis of genetic association studies
(2008)The number of published genetic association studies (GASs) is increasing tremendously due to the availability of mapped single-nucleotide polymorphisms (SNPs) and advances in genotyping technologies. A search in HuGENet ... -
Variance estimation of allele-based odds ratio in the absence of Hardy-Weinberg equilibrium
(2008)In gene-disease association studies, deviation from Hardy-Weinberg equilibrium in controls may cause bias in estimating the allele-based estimates of genetic effects. An approach to adjust the variance of allele-based odds ... -
Variants of the MTHFR gene and susceptibility to acute lymphoblastic leukemia in children: A synthesis of genetic association studies
(2012)Background: Acute lymphoblastic leukemia (ALL) is a complex disease with genetic background. The genetic association studies (GAS) that investigated the association between ALL and the MTHFR C677T and A1298C gene variants ...