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Proteasome modulation: A way to delay aging?
(2019)The ability to maintain a functional proteome, or proteostasis, is challenged as aging progresses. Misfolded and damaged proteins accumulate with age, causing perturbations to cellular and tissue function that hallmarks a ... -
Proteasome or immunoproteasome inhibitors cause apoptosis in human renal tubular epithelial cells under normoxic and hypoxic conditions
(2016)Purpose: Ischemic acute kidney injury is characterized by apoptosis of tubular epithelial cells. Proteasome plays a key role in cellular processes such as proliferation, apoptosis and inflammation. The results of animal ... -
Protected cultivation in Mediterranean region
(2021)Protected cultivation includes different types of structures protecting the plants from harsh environmental conditions, extending the cultivation season, and or providing out-of-season crop production. Although commercially ... -
Protection of 100kWp photovoltaic system against atmospheric overvoltages: A case study
(2016)Photovoltaic (PV) systems, due to their installation position, are exposed to direct and indirect lightning hits, which can damage the equipment of the system, resulting in interruption of the power supply, repair or/and ... -
Protection of the Cultural Heritage from Underground Metro Vibration and Ground-Borne Noise in Athens Centre: The Case of the Kerameikos Archaeological Museum and Gazi Cultural Centre
(2012)This paper describes the assessment, implementation and verification of the necessary mitigation measures for the protection of the Hellenic cultural heritage of the Kerameikos Museum and archaeological area and the Gazi ... -
The protection of the employees in the event of transfers of undertakings in European and Greek Labour Law
(2006)The subject of the present research is the study, in the light of the European and Greek labour law, of the institution of the employer change in its most important manifestation, the undertaking’s transfer. Furthermore, ... -
Protective Effect of Atorvastatin in Cultured Osteoarthritic Chondrocytes
(2010)The aim of our study was to evaluate the in vitro effect of an HMG-CoA reductase inhibitor, atorvastatin, on the expression of significant anabolic and catabolic genes in human osteoarthritic chondrocytes and to explore ... -
The protective effect of LRRK2 p.R1398H on risk of Parkinson's disease is independent of MAPT and SNCA variants
(2014)The best validated susceptibility variants for Parkinson's disease are located in the α-synuclein (SNCA) and microtubule-associated protein tau (MAPT) genes. Recently, a protective p.N551K-R1398H-K1423K haplotype in the ... -
Protective Effects of Systiva® Seed Treatment Fungicide for the Control of Winter Wheat Foliar Diseases Caused at Early Stages Due to Climate Change
(2022)Foliar fungal diseases are a serious threat to winter wheat production and climate change appears to favor pathogens associated with leaf blotch and tan spot symptoms in the Mediterranean area. The present work aimed to ... -
Protective role of local Al cladding against corrosion damage and hydrogen embrittlement of 2024 aluminum alloy specimens
(2005)The present investigation aims to inquire whether At cladding of 2024 aluminum alloy specimens could provide, additionally to the expected protection against corrosion damage, also a protection against the corrosion induced ... -
The Protective Role of Melatonin in Sperm Cryopreservation of Farm Animals and Human: Lessons for Male Fish Cryopreservation
(2022)Cryopreservation is a technique that offers various advantages, especially in fish, among others, that makes the reproduction of species easier through a constant supply of sperm, synchronization of the gamete availability ... -
Protein and mRNA expression levels of VEGF-A and TGF-B1 in different types of human coronary atherosclerotic lesions
(2005)It is well documented that inflammation plays a major role in the establishment and progression of atherosclerosis. Endothelial cells, vascular smooth muscle cells and m onocytes/macrophages are involved in this process ... -
Protein misfolding in neurodegenerative diseases
(2004)A common pathogenic mechanism shared by diverse neurodegenerative disorders, like Alzheimer's disease, Parkinson's disease, Huntington's disease and transmissible spongiform encephalopathies, may be altered protein homeostasis ... -
Protein network and pathway analysis in a pharmacogenetic study of cyclosporine treatment response in Greek patients with psoriasis
(2022)Although cyclosporine comprises a well-established systemic therapy for psoriasis, patients show important heterogeneity in their treatment response. The aim of our study was the pharmacogenetic analysis of 200 Greek ... -
Protein nutrition in crustaceans
(2006)Successful commercial aquaculture of crustacean species is dependent on satisfying their nutritional requirements and on producing rapidly growing and healthy animals. This paper provides an overview of current knowledge ... -
Protein phosphatase PPP3CA (calcineurin A) down-regulates hypoxia-inducible factor transcriptional activity
(2019)Hypoxia-inducible factors (HIF) are master regulators of the response to hypoxia. Although several kinases are known to modify their oxygen sensitive HIF-α subunits or affect indirectly their function, little is known about ... -
Protein synthesis in crustaceans: a review focused on feeding and nutrition
(2014)This review aimed to place crustacean research on in vivo protein synthesis into a broader context, assess its potential for providing further insights into crustacean nutrition and physiology, and recommend future directions ... -
Protein synthesis in gilthead sea bream: response to partial fishmeal replacement
(2012)The present study aimed to measure tissue protein synthesis in sea bream fed isonitrogenous diets that contained 63, 55 and 50% fishmeal; in the latter two diets, 16 and 27% of the fishmeal protein was replaced with plant ... -
Protein-based supplementation to enhance recovery in team sports: What is the evidence?
(2019)Protein supplementation is a major nutritional practice among professional and amateur team-sport athletes representing a market of $5 billion in the USA alone. This practice, however, may not be supported by evidence-based ... -
Protein-protein interaction (ppi) network: Recent advances in drug discovery
(2017)Background: The investigation of the cellular components, their interactions and related functions constitute the major conditions in order to understand the cell as an integrated system. More specifically, the Protein-Protein ...