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Association of hypertensive intracerebral hemorrhage with left ventricular hypertrophy on transthoracic echocardiography
Pallesen L.-P., Wagner J., Lambrou D., Braun S., Weise M., Prakapenia A., Barlinn J., Siepmann T., Winzer S., Moustafa H., Kitzler H.H., Barlinn K., Reichmann H., Puetz V. (2020)Introduction: Arterial hypertension is the most frequent cause for spontaneous intracerebral hemorrhage (sICH) and may also cause left ventricular hypertrophy (LVH). We sought to analyze whether hypertensive sICH etiology ... -
Associations between change in blood pressure and functional outcome, early events and death: Results from the Efficacy of Nitric Oxide in Stroke trial
Sandset E.C., Appleton J.P., Berge E., Christensen H., Gommans J., Krishnan K., Ntaios G., Phillips S., Pocock S., Sprigg N., Woodhouse L.J., Bath P.M. (2019)Objectives:High blood pressure (BP) is associated with a poor outcome after acute stroke. Early reduction in BP may be associated with fewer early adverse events and deaths, and improved functional outcome.Methods:Analyses ... -
ASTRAL, DRAGON and SEDAN scores predict stroke outcome more accurately than physicians
Ntaios G., Gioulekas F., Papavasileiou V., Strbian D., Michel P. (2016)Background and purpose: ASTRAL, SEDAN and DRAGON scores are three well-validated scores for stroke outcome prediction. Whether these scores predict stroke outcome more accurately compared with physicians interested in ... -
Atrial Cardiopathy and Likely Pathogenic Patent Foramen Ovale in Embolic Stroke of Undetermined Source
Leventis I.A., Sagris D., Strambo D., Perlepe K., Sirimarco G., Nannoni S., Korompoki E., Manios E., Makaritsis K., Vemmos K., Michel P., Ntaios G. (2021)Background Atrial cardiopathy and likely pathogenic patent foramen ovale (PFO) are two potential embolic sources in patients with embolic stroke of undetermined source (ESUS). The relationship between these two mechanisms ... -
Cardiovascular care of patients with stroke and high risk of stroke: The need for interdisciplinary action: A consensus report from the European Society of Cardiology Cardiovascular Round Table
Doehner W., Mazighi M., Hofmann B.M., Lautsch D., Hindricks G., Bohula E.A., Byrne R.A., Camm A.J., Casadei B., Caso V., Cognard C., Diener H.-C., Endres M., Goldstein P., Halliday A., Hopewell J.C., Jovanovic D.R., Kobayashi A., Kostrubiec M., Krajina A., Landmesser U., Markus H.S., Ntaios G., Pezzella F.R., Ribo M., Rosano G.M.C., Rubiera M., Sharma M., Touyz R.M., Widimsky P. (2020)Comprehensive stroke care is an interdisciplinary challenge. Close collaboration of cardiologists and stroke physicians is critical to ensure optimum utilisation of short- and long-term care and preventive measures in ... -
Central masked adjudication of stroke diagnosis at trial entry offered no advantage over diagnosis by local clinicians: Secondary analysis and simulation
Godolphin P.J., Hepburn T., Sprigg N., Walker L., Berge E., Collins R., Gommans J., Ntaios G., Pocock S., Prasad K., Wardlaw J.M., Bath P.M., Montgomery A.A. (2018)Background: Central adjudication of stroke type is commonly implemented in large multicentre clinical trials. We investigated the effect of central adjudication of diagnosis of stroke type at trial entry in the Efficacy ... -
Clinical outcomes and neuroimaging profiles in nondisabled patients with anticoagulant-related intracerebral hemorrhage
Lioutas V.-A., Goyal N., Katsanos A.H., Krogias C., Zand R., Sharma V.K., Varelas P., Malhotra K., Paciaroni M., Sharaf A., Chang J., Karapanayiotides T., Kargiotis O., Pappa A., Mai J., Pandhi A., Schroeder C., Tsantes A., Mehta C., Kerro A., Khan A., Mitsias P.D., Selim M.H., Alexandrov A.V., Tsivgoulis G. (2018)Background and Purpose: The aim of this study was to prospectively validate our prior findings of smaller hematoma volume and lesser neurological deficit in nonvitamin K oral anticoagulant (NOAC) compared with Vitamin K ... -
Continuing versus Stopping Prestroke Antihypertensive Therapy in Acute Intracerebral Hemorrhage: A Subgroup Analysis of the Efficacy of Nitric Oxide in Stroke Trial
Krishnan K., Scutt P., Woodhouse L., Adami A., Becker J.L., Cala L.A., Casado A.M., Chen C., Dineen R.A., Gommans J., Koumellis P., Christensen H., Collins R., Czlonkowska A., Lees K.R., Ntaios G., Ozturk S., Phillips S.J., Sprigg N., Szatmari S., Wardlaw J.M., Bath P.M., ENOS Investigators (2016)Background and purpose More than 50% of patients with acute intracerebral hemorrhage (ICH) are taking antihypertensive drugs before ictus. Although antihypertensive therapy should be given long term for secondary prevention, ... -
Effect of continuing versus stopping pre-stroke antihypertensive agents within 12 h on outcome after stroke: A subgroup analysis of the efficacy of nitric oxide in stroke (ENOS) trial
Woodhouse L.J., Appleton J.P., Scutt P., Everton L., Wilkinson G., Caso V., Czlonkowska A., Gommans J., Krishnan K., Laska A.C., Ntaios G., Ozturk S., Phillips S., Pocock S., Prasad K., Szatmari S., Wardlaw J.M., Sprigg N., Bath P.M., ENOS Investigators (2022)Background: It is not known whether to continue or temporarily stop existing antihypertensive drugs in patients with acute stroke. Methods: We performed a prospective subgroup analysis of patients enrolled into the Efficacy ... -
Effect of Glyceryl Trinitrate on Hemodynamics in Acute Stroke: Data from the ENOS Trial
Appleton J.P., Woodhouse L.J., Bereczki D., Berge E., Christensen H.K., Collins R., Gommans J., Ntaios G., Ozturk S., Szatmari S., Wardlaw J.M., Sprigg N., Rothwell P.M., Bath P.M. (2019)Background and Purpose - Increased blood pressure (BP), heart rate, and their derivatives (variability, pulse pressure, rate-pressure product) are associated with poor clinical outcome in acute stroke. We assessed the ... -
Effect of Hyperacute Administration (Within 6 Hours) of Transdermal Glyceryl Trinitrate, a Nitric Oxide Donor, on Outcome after Stroke: Subgroup Analysis of the Efficacy of Nitric Oxide in Stroke (ENOS) Trial
Woodhouse L., Scutt P., Krishnan K., Berge E., Gommans J., Ntaios G., Wardlaw J., Sprigg N., Bath P.M. (2015)Background and Purpose-Nitric oxide donors are candidate treatments for acute stroke, potentially through hemodynamic, reperfusion, and neuroprotectant effects, especially if given early. Although the large Efficacy of ... -
European Stroke Organisation (ESO) guidelines for the management of temperature in patients with acute ischemic stroke
Ntaios, G.; Dziedzic, T.; Michel, P.; Papavasileiou, V.; Petersson, J.; Staykov, D.; Thomas, B.; Steiner, T. (2015)Background: Hyperthermia is a frequent complication in patients with acute ischemic stroke. On the other hand, therapeutically induced hypothermia has shown promising potential in animal models of focal cerebral ischemia. ... -
European Stroke Organisation (ESO) guidelines on glycaemia management in acute stroke
Fuentes B., Ntaios G., Putaala J., Thomas B., Turc G., Díez-Tejedor E., for the European Stroke Organisation (2018)Background: Hyperglycaemia is a frequent complication in acute stroke that has been shown to be independently associated with larger infarct size, haematoma growth, poor clinical outcome and mortality. This Guideline ... -
External validation of the ASTRAL score to predict 3-and 12-month functional outcome in the china national stroke registry
Liu, G.; Ntaios, G.; Zheng, H.; Wang, Y.; Michel, P.; Wang, D. Z.; Fang, J.; Papavasileiou, V.; Liu, L.; Dong, K.; Wang, C.; Zhao, X. (2013)BACKGROUND AND PURPOSE-: The ASTRAL score was recently introduced as a prognostic tool for acute ischemic stroke. It predicts 3-month outcome reliably in both the derivation and the validation European cohorts. We aimed ... -
External Validation of the PREMISE Score in the Athens Stroke Registry
Ntaios G., Georgiopoulos G., Koroboki E., Vemmos K. (2019)Background: A simple score was proposed recently for Predicting Early Mortality from Ischemic Stroke (PREMISE) derived from the Austrian Stroke Unit Registry. This score could be useful in clinical practice and research. ... -
Glyceryl trinitrate for acute intracerebral hemorrhage: Results from the Efficacy of Nitric Oxide in Stroke (ENOS) trial, a subgroup analysis
Krishnan K., Scutt P., Woodhouse L., Adami A., Becker J.L., Berge E., Cala L.A., Casado A.M., Caso V., Chen C., Christensen H., Collins R., Czlonkowska A., Dineen R.A., Gommans J., Koumellis P., Lees K.R., Ntaios G., Ozturk S., Phillips S.J., Pocock S.J., De Silva A., Sprigg N., Szatmari S., Wardlaw J.M., Bath P.M. (2016)Background and Purpose - The Efficacy of Nitric Oxide in Stroke (ENOS) trial found that transdermal glyceryl trinitrate (GTN, a nitric oxide donor) lowered blood pressure but did not improve functional outcome in patients ... -
Hemicraniectomy for Dominant vs Nondominant Middle Cerebral Artery Infarction: A Systematic Review and Meta-Analysis
Räty S., Georgiopoulos G., Aarnio K., Martinez-Majander N., Uhl E., Ntaios G., Strbian D. (2021)Objectives: Decompressive hemicraniectomy decreases mortality and severe disability from space-occupying middle cerebral artery infarction in selected patients. However, attitudes towards hemicraniectomy for dominant-hemispheric ... -
Hemorrhagic transformation in patients with acute ischemic stroke and atrial fibrillation: Time to initiation of oral anticoagulant therapy and outcomes
Paciaroni M., Bandini F., Agnelli G., Tsivgoulis G., Yaghi S., Furie K.L., Tadi P., Becattini C., Zedde M., Abdul-Rahim A.H., Lees K.R., Alberti A., Venti M., Acciarresi M., D’Amore C., Mosconi M.G., Cimini L.A., Altavilla R., Volpi G., Bovi P., Carletti M., Rigatelli A., Cappellari M., Putaala J., Tomppo L., Tatlisumak T., Marcheselli S., Pezzini A., Poli L., Padovani A., Masotti L., Vannucchi V., Sohn S.-I., Lorenzini G., Tassi R., Guideri F., Acampa M., Martini G., Ntaios G., Athanasakis G., Makaritsis K., Karagkiozi E., Vadikolias K., Liantinioti C., Chondrogianni M., Mumoli N., Consoli D., Galati F., Sacco S., Carolei A., Tiseo C., Corea F., Ageno W., Bellesini M., Colombo G., Silvestrelli G., Ciccone A., Lanari A., Scoditti U., Denti L., Mancuso M., Maccarrone M., Ulivi L., Orlandi G., Giannini N., Gialdini G., Tassinari T., De Lodovici M.L., Bono G., Rueckert C., Baldi A., D'Anna S., Toni D., Letteri F., Giuntini M., Lotti E.M., Flomin Y., Pieroni A., Kargiotis O., Karapanayiotides T., Monaco S., Baronello M.M., Csiba L., Szabó L., Chiti A., Giorli E., Del Sette M., Imberti D., Zabzuni D., Doronin B., Volodina V., Michel P., Vanacker P., Barlinn K., Pallesen L.-P., Barlinn J., Deleu D., Melikyan G., Ibrahim F., Akhtar N., Gourbali V., Caso V. (2018)Background—In patients with acute ischemic stroke and atrial fibrillation, early anticoagulation prevents ischemic recurrence but with the risk of hemorrhagic transformation (HT). The aims of this study were to evaluate ... -
Infections Up to 76 Days After Stroke Increase Disability and Death
Learoyd A.E., Woodhouse L., Shaw L., Sprigg N., Bereczki D., Berge E., Caso V., Christensen H., Collins R., Czlonkowska A., El Etribi A., Farr T.D., Gommans J., Laska A.-C., Ntaios G., Ozturk S., Pocock S.J., Prasad K., Wardlaw J.M., Fone K.C., Bath P.M., Trueman R.C., on behalf of the ENOS Trial investigators (2017)Early infection after stroke is associated with a poor outcome. We aimed to determine whether delayed infections (up to 76 days post-stroke) are associated with poor outcome at 90 days. Data came from the international ... -
Intravenous Thrombolysis in Patients With Ischemic Stroke Aged ≥90 Years: A Cohort Study From the TRISP Collaboration
Altersberger V.L., Rusche N., Martinez-Majander N., Hametner C., Scheitz J.F., Henon H., Dell'acqua M.L., Strambo D., Stolp J., Heldner M.R., Grisendi I., Jovanovic D.R., Bejot Y., Pezzini A., Leker R.R., Kägi G., Wegener S., Cereda C.W., Lindgren E., Ntaios G., Piot I., Polymeris A.A., Lyrer P.A., Räty S., Sibolt G., Tiainen M., Heyse M., Erdur H., Kaaouana O., Padjen V., Zedde M., Arnold M., Nederkoorn P.J., Michel P., Bigliardi G., Zini A., Cordonnier C., Nolte C.H., Ringleb P.A., Curtze S., Engelter S.T., Gensicke H., for the Thrombolysis in Stroke Patients (TRISP) Collaborators (2022)Background: The probability to receive intravenous thrombolysis (IVT) for treatment of acute ischemic stroke declines with increasing age and is consequently the lowest in very elderly patients. Safety concerns likely ...