Listar por tema "DATABASE"
Mostrando ítems 1-12 de 12
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Combined prediction of Tat and Sec signal peptides with hidden Markov models
(2010)Motivation: Computational prediction of signal peptides is of great importance in computational biology. In addition to the general secretory pathway ( Sec), Bacteria, Archaea and chloroplasts possess another major pathway ... -
A Comprehensive Phylogenetic Analysis of Deadenylases
(2013)Deadenylases catalyze the shortening of the poly(A) tail at the messenger ribonucleic acid (mRNA) 3'-end in eukaryotes. Therefore, these enzymes influence mRNA decay, and constitute a major emerging group of promising ... -
Creating a specialist protein resource network: a meeting report for the protein bioinformatics and community resources retreat
(2015)During 11-12 August 2014, a Protein Bioinformatics and Community Resources Retreat was held at the Wellcome Trust Genome Campus in Hinxton, UK. This meeting brought together the principal investigators of several specialized ... -
Field Synopsis and Synthesis of Genetic Association Studies in Osteoarthritis: The CUMAGAS-OSTEO Information System
(2010)A comprehensive and systematic assessment of the current status of genetic association studies (GAS) for osteoarthntis was conducted. Data from 327 GAS involving 187 distinct genetic variants were analyzed and cataloged ... -
Genomic Convergence of Genome-wide Investigations for Complex Traits
(2009)Genome-wide investigations for identifying the genes for complex traits are considered to be agnostic in terms of prior assumptions for the responsible DNA alterations. The agreement of genome-wide association studies ... -
The Hellenic type of nondeletional hereditary persistence of fetal hemoglobin results from a novel mutation (g.-109G > T) in the HBG2 gene promoter
(2009)Nondeletional hereditary persistence of fetal hemoglobin (nd-HPFH), a rare hereditary condition resulting in elevated levels of fetal hemoglobin (Hb F) in adults, is associated with promoter mutations in the human fetal ... -
HMMpTM: Improving transmembrane protein topology prediction using phosphorylation and glycosylation site prediction
(2014)During the last two decades a large number of Computational methods have been developed for predicting transmembrane protein topology. Current predictors rely on topogenic signals in the protein sequence, such as the ... -
Increased gamma-globin gene expression in beta-thalassemia intermedia patients correlates with a mutation in 3'HS1
(2007)We report a novel set of genetic markers in the DNasel hypersensitive sites comprising the human P-globin locus chromatin hub (CH), namely HS-111 and 3'HS1. The HS-111 (-21 G>A) and 3'HS1 (+179 C>T) transitions form CH ... -
Online resources for miRNA analysis
(2013)Objective: This review aims to provide a brief introduction to each major category of available tools and algorithms for microRNA (miRNA) research, as well as to present some of the most widely used or promising representative ... -
Polymorphisms of the endothelial nitric oxide synthase gene in breast cancer: a genetic association study and meta-analysis
(2010)The endothelial nitric oxide synthase gene (NOS3) has been proposed as a candidate gene for breast cancer (BC), however, the specific role of variants and haplotypes has not been clarified. We examined the association of ... -
Synopsis and meta-analysis of genetic association studies in osteoporosis for the focal adhesion family genes: the CUMAGAS-OSTEOporosis information system
(2011)Background: Focal adhesion (FA) family genes have been studied as candidate genes for osteoporosis, but the results of genetic association studies (GASs) are controversial. To clarify these data, a systematic assessment ...