Browsing by Author "Koutsoumpas, A. L."
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Autoantibodies in autoimmune pancreatitis
Smyk, D. S.; Rigopoulou, E. I.; Koutsoumpas, A. L.; Kriese, S.; Burroughs, A. K.; Bogdanos, D. P. (2012)Autoimmune pancreatitis (AIP) was first used to describe cases of pancreatitis with narrowing of the pancreatic duct, enlargement of the pancreas, hyper - globulinaemia, and antinuclear antibody (ANA) positivity serologically. ... -
Bioinformatic and immunological analysis reveals lack of support for measles virus related mimicry in Crohn's disease
Polymeros, D.; Tsiamoulos, Z. P.; Koutsoumpas, A. L.; Smyk, D. S.; Mytilinaiou, M. G.; Triantafyllou, K.; Bogdanos, D. P.; Ladas, S. D. (2014)Background: A link between measles virus and Crohn's disease (CD) has been postulated. We assessed through bioinformatic and immunological approaches whether measles is implicated in CD induction, through molecular mimicry. ... -
Diagnostic and clinical significance of Crohn's disease-specific anti-MZGP2 pancreatic antibodies by a novel ELISA
Pavlidis, P.; Shums, Z.; Koutsoumpas, A. L.; Milo, J.; Papp, M.; Umemura, T.; Lakatos, P. L.; Smyk, D. S.; Bogdanos, D. P.; Forbes, A.; Norman, G. L. (2015)Background: We developed a new IgA and IgG anti-MZGP2 antibody ELISAs based on recombinant isoform-4 of human zymogen granule protein-2 (GP2), which is the major autoantigen of Crohn's disease (CrD)-specific pancreatic ... -
Diagnostic and clinical utility of antibodies against the nuclear body promyelocytic leukaemia and Sp100 antigens in patients with primary biliary cirrhosis
Mytilinaiou, M. G.; Meyer, W.; Scheper, T.; Rigopoulou, E. I.; Probst, C.; Koutsoumpas, A. L.; Abeles, D.; Burroughs, A. K.; Komorowski, L.; Vergani, D.; Bogdanos, D. P. (2012)Background: The lack of an immunoassay that detects antibodies to promyelocytic leukaemia (PML) protein, the primary biliary cirrhosis (PBC)-specific multiple nuclear dot (MND) antigen, has prompted us to develop a line ... -
Helicobacter pylori and autoimmune disease: Cause or bystander
Smyk, D. S.; Koutsoumpas, A. L.; Mytilinaiou, M. G.; Rigopoulou, E. I.; Sakkas, L. I.; Bogdanos, D. P. (2014)Helicobacter pylori (H. pylori) is the main cause of chronic gastritis and a major risk factor for gastric cancer. This pathogen has also been considered a potential trigger of gastric autoimmunity, and in particular of ... -
Ileal InflammationMay Trigger the Development of GP2-Specific Pancreatic Autoantibodies in Patients with Crohn's Disease
Pavlidis, P.; Romanidou, O.; Roggenbuck, D.; Mytilinaiou, M. G.; Al-Sulttan, F.; Liaskos, C.; Smyk, D. S.; Koutsoumpas, A. L.; Rigopoulou, E. I.; Conrad, K.; Forbes, A.; Bogdanos, D. P. (2012)Why zymogen glycoprotein 2 (GP2), the Crohn's disease (CD)-specific pancreatic autoantigen, is the major target of humoral autoimmunity in inflammatory bowel diseases (IBD) is uknown. Recent evidence demonstrates that GP2 ... -
Popular and unpopular infectious agents linked to primary biliary cirrhosis
Koutsoumpas, A. L.; Kriese, S.; Rigopoulou, E. I. (2012)Primary biliary cirrhosis (PBC) is a progressive cholestatic liver disease characterized by the autoimmune destruction of the biliary epithelial cells of the small and medium-size bile ducts. The disease affects middle ...