Πλοήγηση ανά Θέμα "radiotherapy"
Αποτελέσματα 1-15 από 15
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Cancer vascularization: Implications in radiotherapy?
(2000)Purpose: Although hypoxia is considered a major cause of failure of radiotherapy, the mechanisms of tumor hypoxia are unclear, and effective ways for its correction or targeting are missing. Tumoral vasculature is the ... -
Challenges and Choices in Prostate Cancer Irradiation: From the Three Dimensional Conformal Radiotherapy to the Era of Intensity Modulated, Image-Guided and Adaptive Radiation Treatment
(2014)In the last decades the status of radiotherapy was tremendously increased in terms of conformity to the target as well as image-guided techniques in conjunction with intensity-modulated radiotherapy (IMRT). The technological ... -
Clinical and experimental evidence of bcl-2 involvement in the response to photodynamic therapy
(2001)Purpose: The role of apoptosis related proteins in the response of human malignancies to photodynamic therapy (PDT) is under investigation. The aim of the study was to examine the role of p53 and of bcl-2 protein expression ... -
A comparison of Monte Carlo simulation with experimental dosimetric techniques for a 6 MV stereotactic radiotherapy unit
(2004)Purpose: To compare Monte Carlo simulation with conventional dosimetry techniques for stereotactic radiotherapy (SRT), since accurate dosimetry of narrow photon beams is very complicated and has often been questioned, ... -
Dose Escalation of Amifostine for Radioprotection During Pelvic Accelerated Radiotherapy
(2013)Objectives: Experimental data suggest a dose-dependent efficacy of amifostine so that the low overall doses used in clinical trials may have masked the full potential of the drug. In this study, we report our experience ... -
Effect of single dose irradiation on human glioblastoma spheroids in vitro
(2004)Investigation of the predictive value of a radiosurgery-relevant treatment of glioblastoma spheroids. Organotypic multicellular spheroids were cultured and irradiated (20 Gy). Morphology, apoptosis and immunohistochemical ... -
High intratumoural accumulation of stealth (R) liposomal doxorubicin (Caelyx (R)) in glioblastomas and in metastatic brain tumours
(2000)The blood-brain barrier is a major obstacle for the chemotherapeutic drugs to effectively reach primary or secondary brain tumours. Stealth(R) liposomal drugs are highly accumulated in tumoural tissues. In the present study ... -
Local intracerebral inhibition of IRE1 by MKC8866 sensitizes glioblastoma to irradiation/chemotherapy in vivo
(2020)Glioblastoma multiforme (GBM) is the most severe primary brain cancer. Despite an aggressive treatment comprising surgical resection and radio/chemotherapy, patient's survival post diagnosis remains short. A limitation for ... -
Monte Carlo dosimetric evaluation of high energy vs low energy photon beams in low density tissues
(2006)Background and purpose: Low megavoltage photon beams are often the treatment choice in radiotherapy when low density heterogeneities are involved, because higher energies show some undesirable dosimetric effects. This work ... -
Oncologic children undergoing radiotherapy: Ways to alleviate the psychological burden: A review
(2021)Background: Radiation therapy is stressful for both the patient and family. After a child's cancer diagnosis, parents face the burden of dealing with fear, their children's needs and the unfamiliarity of radiotherapy ... -
Otto Hahn (1879-1968): pioneer in radiochemistry and discoverer of radiotherapeutic mesothorium
(2014)Otto Hahn was a German innovative chemist. He had discovered various radioactive elements, as well as the nuclear fission. He finally received the Nobel Prize for his participation in the atomic energy project, which Hahn ... -
Prognostic impact of tumor volumetry in patients with locally advanced head-and-neck carcinoma (non-nasopharyngeal) treated by radiotherapy alone or combined radiochemotherapy in a randomized trial
(2004)Purpose: Tumor volume (TV) is one of the main reported factors determining the outcome of treatment in head-and-neck carcinomas. In this study, the prognostic impact of TV was explored in the context of a randomized trial ... -
Radiotherapy for Hodgkin's lymphoma: too hard to die?
(2012)The treatment of Hodgkin's lymphoma (HL) is associated with significant toxicity. The objective of high quality management is to keep the concept of combined modality, while trying to decrease the radiation dose, to diminish ... -
Treatment of Low-risk Prostate Cancer with Radical Hypofractionated Accelerated Radiotherapy with Cytoprotection (HypoARC): An Interim Analysis of Toxicity and Efficacy
(2011)Aim: Radiobiological analysis of clinical data suggests that prostate cancer has a low alpha/beta ratio, implying that large radiotherapy fractions may better control the disease. Acceleration of radiotherapy may be also ... -
A weekly hypofractionated radiotherapeutic schedule for bladder carcinoma in elderly patients: local response, acute and late toxicity, dosimetric parameters and pain relief
(2013)Purpose: To investigate the early and late toxicity of a hypofractionated radiotherapy (RT) schedule to treat muscle-invasive bladder cancer in relation to radiation parameters according to the organs at risk. Methods: ...