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Πλοήγηση ανά Θέμα "protein IRE1"

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    • CD90/Thy-1, a cancer-associated cell surface signaling molecule 

      Sauzay C., Voutetakis K., Chatziioannou A.A., Chevet E., Avril T. (2019)
      CD90 is a membrane GPI-anchored protein with one Ig V-type superfamily domain that was initially described in mouse T cells. Besides the specific expression pattern and functions of CD90 that were described in normal tissues ...

    • Local intracerebral inhibition of IRE1 by MKC8866 sensitizes glioblastoma to irradiation/chemotherapy in vivo 

      Le Reste P.J., Pineau R., Voutetakis K., Samal J., Jégou G., Lhomond S., Gorman A.M., Samali A., Patterson J.B., Zeng Q., Pandit A., Aubry M., Soriano N., Etcheverry A., Chatziioannou A., Mosser J., Avril T., Chevet E. (2020)
      Glioblastoma multiforme (GBM) is the most severe primary brain cancer. Despite an aggressive treatment comprising surgical resection and radio/chemotherapy, patient's survival post diagnosis remains short. A limitation for ...

    • Low-Protein Diet Induces IRE1α-Dependent Anticancer Immunosurveillance 

      Rubio-Patiño C., Bossowski J.P., De Donatis G.M., Mondragón L., Villa E., Aira L.E., Chiche J., Mhaidly R., Lebeaupin C., Marchetti S., Voutetakis K., Chatziioannou A., Castelli F.A., Lamourette P., Chu-Van E., Fenaille F., Avril T., Passeron T., Patterson J.B., Verhoeyen E., Bailly-Maitre B., Chevet E., Ricci J.-E. (2018)
      Dietary restriction (DR) was shown to impact on tumor growth with very variable effects depending on the cancer type. However, how DR limits cancer progression remains largely unknown. Here, we demonstrate that feeding ...

    • Transcription of the NKG2D ligand MICA is suppressed by the IRE1/XBP1 pathway of the unfolded protein response through the regulation of E2F1 

      Obiedat A., Seidel E., Mahameed M., Bernani O., Tsukerman P., Voutetakis K., Chatziioannou A., Mcmahon M., Avril T., Chevet E., Mandelboim O., Tirosh B. (2019)
      The unfolded protein response (UPR) is an adaptive signaling pathway activated in response to endoplasmic reticulum (ER) stress. The effectors of the UPR are potent transcription activators; however, some genes are suppressed ...