Πλοήγηση ανά Θέμα "immunopathogenesis"
Αποτελέσματα 1-15 από 15
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Autoantibodies and autoantigens associated with autoimmune hepatitis and viruses-induced autoimmune response: Significant tools in clinical practice and in the study of pathogenesis of autoimmune hepatic diseases
(2004)Autoimmune hepatitis (AIH) is a chronic necroinflammatory disease of the liver characterized by hypergamma-globulinemia, characteristic autoantibodies, association with HLA DR3 or DR4 and a favorable response to immunosuppressive ... -
The autoimmunity–oral microbiome connection
(2017)To date, there is a major effort in deciphering the role of complex microbial communities, especially the oral and gut microbiomes, in the pathogenesis of various diseases. Increasing evidence indicates a key role for the ... -
A comprehensive analysis of antigen-specific antibody responses against human cytomegalovirus in patients with systemic sclerosis
(2019)Anti-human cytomegalovirus (HCMV) antibodies are considered triggers of systemic sclerosis (SSc), but such a hypothesis has been assessed in limited sub-dominant epitopes. Our aim was to systematically assess the potential ... -
Genetics of Hereditary Angioedema Revisited
(2016)Contemporary genetic research has provided evidences that angioedema represents a diverse family of disorders related to kinin metabolism, with a much greater genetic complexity than was initially considered. Convincing ... -
The immunopathogenetic role of autoantibodies in canine autoimmune hepatitis: Lessons to learn from human autoimmune hepatitis
(2012)Autoimmune hepatitis (AIH) is not a disease entity restricted to man, but it can be found in other animals including canines. An increasing number of studies have focused on the immunopathogenesis of human autoimmune ... -
Molecular diagnostics of primary billary cirrhosis
(2008)Background: Primary biliary cirrhosis (PBC) is an autoimmune liver disease of unknown etiology characterized by the presence of antimitochondrial antibodies (AMA) in 90 - 95% of patients. AMA are directed against members ... -
Multiple autoimmune propensity and B-Non-Hodgkin lymphoma: Cause or effect?
(2011)We report a case of multiple autoimmunity consisting of the presence of autoimmune haemolytic anaemia (AIHA), antimitochondrial antibodies (AMAs), and antiphospholipid antibodies (APLAbs) as the presenting manifestations ... -
P38 MAPK signaling in pemphigus: Implications for skin autoimmunity
(2013)p38 mitogen activated protein kinase (p38 MAPK) signaling plays a major role in the modulation of immune-mediated inflammatory responses and therefore has been linked with several autoimmune diseases. The extent of the ... -
Pancreatic anti-GP2 and anti-Saccharomyces cerevisiae antibodies in ruminants with paratuberculosis: A better understanding of the immunopathogenesis of Crohn's disease
(2020)Introduction: Ruminants (cattle and sheep) with Mycobacterium avium (MAP)-induced paratuberculosis (ptb), the ruminant model of Crohn's disease (CD), exhibit pancreatic specific autoantibodies (PAB) against GP2 but not ... -
Popular and unpopular infectious agents linked to primary biliary cirrhosis
(2012)Primary biliary cirrhosis (PBC) is a progressive cholestatic liver disease characterized by the autoimmune destruction of the biliary epithelial cells of the small and medium-size bile ducts. The disease affects middle ... -
Primary biliary cirrhosis associated with systemic sclerosis: Diagnostic and clinical challenges
(2011)Patients with primary biliary cirrhosis (PBC) often have concurrent limited systemic sclerosis (SSc). Conversely, up to one-fourth of SSc patients are positive for PBC-specific antimitochondrial antibodies (AMA). The ... -
The role of platelets in autoimmunity, vasculopathy, and fibrosis: Implications for systemic sclerosis
(2017)Introduction Systemic sclerosis (SSc) is an autoimmune disease characterized by vasculopathy, autoimmunity, and widespread dermal and visceral fibrosis. This article summarizes the current knowledge about the potential ... -
Systemic sclerosis: From pathogenesis towards targeted immunotherapies
(2012)Systemic sclerosis (SSc), a chronic disease with widespread collagen deposition, has three pathogenetic facets: immune activation, microvasculopathy and fibroblast activation. Immune activation and microvasculopathy occur ... -
Toll-like receptors and their role in renal pathologies
(2012)Toll-like receptors (TLRs) are the first identified and best studied family of pattern recognition receptors. Expressed in immunocytes, TLRs initiate innate immune responses and concurrently shape the subsequent adaptive ... -
Towards systemic sclerosis and away from primary biliary cirrhosis: The case of PTPN22
(2012)Primary biliary cirrhosis (PBC) is a chronic cholestatic liver disease characterized by immune-mediated destruction of the small and medium size intrahepatic bile ducts. PBC patients often have concomitant autoimmune ...