Πλοήγηση ανά Θέμα "DEADENYLATION"

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Inhibition of human poly(A)-specific ribonuclease (PARN) by purine nucleotides: kinetic analysis

Balatsos, N. A. A.; Anastasakis, D.; Stathopoulos, C. (2009)

Poly(A)-specific ribonuclease (PARN) is a cap-interacting and poly(A)-specific 3'-exoribonuclease that efficiently degrades mRNA poly(A) tails. Based on the enzyme's preference for its natural substrates, we examined the ...
An Integrated In Silico Approach to Design Specific Inhibitors Targeting Human Poly(A)-Specific Ribonuclease

Vlachakis, D.; Pavlopoulou, A.; Tsiliki, G.; Komiotis, D.; Stathopoulos, C.; Balatsos, N. A. A.; Kossida, S. (2012)

Poly(A)-specific ribonuclease (PARN) is an exoribonuclease/deadenylase that degrades 3'-end poly(A) tails in almost all eukaryotic organisms. Much of the biochemical and structural information on PARN comes from the human ...