Πλοήγηση ανά Συγγραφέα "Rigopoulou, E. I."
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Lamivudine plus interleukin-12 combination therapy in chronic hepatitis B: Antiviral and immunological activity
Rigopoulou, E. I.; Suri, D.; Chokshi, S.; Mullerova, I.; Rice, S.; Tedder, R. S.; Williams, R.; Naoumov, N. V. (2005)Interleukin-12 (IL-12) is an immunomodulatory cytokine that promotes cellular immunity. Pre-clinical data suggest that IL-12 inhibits hepatitis B virus (HBV) replication by stimulating interferon-gamma (IFN-γ) production. ... -
Longitudinal determination of IgA isotype-specific antibodies targeting the major recombinant mitochondrial antigens in patients with primary biliary cirrhosis
Spyrou, E.; Komorowski, L.; Probst, C.; Rigopoulou, E. I.; Bogdanos, D. P.; Dalekos, G. N. (2013) -
Markers of cell activation and apoptosis in bone marrow mononuclear cells of patients with autoimmune hepatitis type 1 and primary biliary cirrhosis
Tsikrikoni, A.; Kyriakou, D. S.; Rigopoulou, E. I.; Alexandrakis, M. G.; Zachou, K.; Passam, F.; Dalekos, G. N. (2005) -
Molecular diagnostics of primary billary cirrhosis
Rigopoulou, E. I.; Dalekos, G. N. (2008)Background: Primary biliary cirrhosis (PBC) is an autoimmune liver disease of unknown etiology characterized by the presence of antimitochondrial antibodies (AMA) in 90 - 95% of patients. AMA are directed against members ... -
Multiple viral/self immunological cross-reactivity in liver kidney microsomal antibody positive hepatitis C virus-infected patients is associated with the possession of HLA B51
Bogdanos, D. P.; Lenzi, M.; Okamoto, M.; Rigopoulou, E. I.; Muratori, P.; Ma, Y.; Muratori, L.; Tsantoulas, D.; Mieli-Vergani, G.; Bianchi, F. B.; Vergani, D. (2004)Liver Kidney Microsomal autoantibody type 1(LKM1) directed to cytochrome P4502D6 (CYP2D6) characterises autoimmune hepatitis type-2 (AIH-2), but is also found in a proportion of chronic hepatitis C virus (HCV) infected ... -
MYCOPHENOLATE FOR AUTOIMMUNE HEPATITIS TREATMENT: PROSPECTIVE ASSESSMENT OF ITS EFFICACY AND SAFETY FOR INDUCTION AND MAINTENANCE OF REMISSION IN A LARGE COHORT OF TREATMENT-NAIVE PATIENTS
Zachou, K.; Gatselis, N.; Papadamou, G.; Rigopoulou, E. I.; Dalekos, G. N. (2011) -
Mycophenolate for the treatment of autoimmune hepatitis: Prospective assessment of its efficacy and safety for induction and maintenance of remission in a large cohort of treatment-naive patients
Zachou, K.; Gatselis, N.; Papadamou, G.; Rigopoulou, E. I.; Dalekos, G. N. (2011)Background & Aims: Standard therapy for autoimmune hepatitis (AIH) is corticosteroids with or without azathioprine. However, 20% of patients do not respond or are intolerant to conventional treatment. Therefore, we evaluated ... -
Mycophenolate for the treatment of autoimmune hepatitis: Prospective assessment of its efficacy and safety for induction and maintenance of remission in a large cohort of treatment-naïve patients
Zachou, K.; Gatselis, N.; Papadamou, G.; Rigopoulou, E. I.; Dalekos, G. N. (2011)Background & Aims: Standard therapy for autoimmune hepatitis (AIH) is corticosteroids with or without azathioprine. However, 20% of patients do not respond or are intolerant to conventional treatment. Therefore, we evaluated ... -
New sensitive technique for the detection of anti-smooth muscle antibodies in autoimmune hepatitis
Liaskos, C.; Mytilinaiou, M. G.; Grammatikopoulos, A.; Smyk, D. S.; Orfanidou, T.; Mavropoulos, A.; Norman, G. L.; Rigopoulou, E. I.; Mieli-Vergani, G.; Bogdanos, D. P.; Vergani, D. (2012) -
Occult hepatitis B virus infection in patients with autoimmune liver diseases
Georgiadou, S. P.; Zachou, K.; Liaskos, C.; Gabeta, S.; Rigopoulou, E. I.; Dalekos, G. N. (2009)Occult hepatitis B virus (HBV) infection is characterized by undetectable serum HBV surface antigen (HBsAg) but detectable HBV-DNA in serum or liver. To determine the prevalence and clinical impact of occult HBV in autoimmune ... -
Oxidative stress and antioxidant status in patients with autoimmune liver diseases
Kaffe, E. T.; Rigopoulou, E. I.; Koukoulis, G. K.; Dalekos, G. N.; Moulas, A. N. (2015)Objective: To estimate oxidative stress and antioxidant components during different stages of autoimmune liver diseases and assess their possible implication on disease progression. Methods: We determined several markers ... -
P38 MAPK signaling in pemphigus: Implications for skin autoimmunity
Mavropoulos, A.; Orfanidou, T.; Liaskos, C.; Smyk, D. S.; Spyrou, V.; Sakkas, L. I.; Rigopoulou, E. I.; Bogdanos, D. P. (2013)p38 mitogen activated protein kinase (p38 MAPK) signaling plays a major role in the modulation of immune-mediated inflammatory responses and therefore has been linked with several autoimmune diseases. The extent of the ... -
p38 mitogen-activated protein kinase (p38 MAPK)-mediated autoimmunity: Lessons to learn from ANCA vasculitis and pemphigus vulgaris
Mavropoulos, A.; Orfanidou, T.; Liaskos, C.; Smyk, D. S.; Billinis, C.; Blank, M.; Rigopoulou, E. I.; Bogdanos, D. P. (2013)Evidence is beginning to accumulate that p38 mitogen activated protein kinase (p38 MAPK) signaling pathway plays an important role in the regulation of cellular and humoral autoimmune responses. The exact mechanisms and ... -
PBC triggers in water reservoirs, coal mining areas and waste disposal sites: From Newcastle to New York
Smyk, D.; Mytilinaiou, M. G.; Rigopoulou, E. I.; Bogdanos, D. P. (2010)Various environmental factors have been proposed as triggers of primary biliary cirrhosis (PBC), a progressive autoimmune cholestatic liver disease which is characterised by the destruction of the small intrahepatic bile ... -
Peculiar antibody reactivity to human connexin 37 and its microbial mimics in patients with Crohn's disease
Koutsoumpas, A.; Polymeros, D.; Tsiamoulos, Z.; Smyk, D.; Karamanolis, G.; Triantafyllou, K.; Rigopoulou, E. I.; Forbes, A.; Vergani, D.; Bogdanos, D. P.; Ladas, S. D. (2011)Background/aims: We found that pooled Crohn's disease (CD) sera strongly react with a human gap-junction connexin 37 (Cx37) peptide and tested for anti-Cx37 antibody reactivity in sera from CD patients and controls. We ... -
PHOSHORYLATION OF P38 MAPK IS DETECTABLE IN NKT CELLS OF PATIENTS WITH AUTOIMMUNE HEPATITIS IN WHOM IT MIRRORS DISEASE ACTIVITY
Mavropoulos, A.; Spyrou, E.; Rigopoulou, E. I.; Vergani, D.; Dalekos, G. N.; Bogdanos, D. P. (2010) -
Popular and unpopular infectious agents linked to primary biliary cirrhosis
Koutsoumpas, A. L.; Kriese, S.; Rigopoulou, E. I. (2012)Primary biliary cirrhosis (PBC) is a progressive cholestatic liver disease characterized by the autoimmune destruction of the biliary epithelial cells of the small and medium-size bile ducts. The disease affects middle ... -
Potential Roles for Infectious Agents in the Pathophysiology of Primary Biliary Cirrhosis: What's New?
Smyk, D. S.; Rigopoulou, E. I.; Bogdanos, D. P. (2013)Primary biliary cirrhosis (PBC) is a progressive cholestatic liver disease serologically characterized by the presence of high-titer antimitochondrial antibodies and, histologically by chronic nonsuppurative cholangitis ... -
Prevalence and clinical significance of isotype specific antinuclear antibodies in primary biliary cirrhosis
Rigopoulou, E. I.; Davies, E. T.; Pares, A.; Zachou, K.; Liaskos, C.; Bogdanos, D. P.; Rodes, J.; Dalekos, G. N.; Vergani, D. (2005)Background: Antinuclear antibodies (ANA) giving a rim-like/membranous (RL/M) or a multiple nuclear dot (MND) pattern are highly specific for primary biliary cirrhosis (PBC). Aim and subjects: To assess the prevalence of ... -
Prevalence of gastric parietal cell antibodies and intrinsic factor antibodies in primary biliary cirrhosis
Liaskos, C.; Norman, G. L.; Moulas, A.; Garagounis, A.; Goulis, I.; Rigopoulou, E. I.; Dalekos, G. N. (2010)Background: We investigated the prevalence of antibodies against gastric parietal cells (GPA), intrinsic factor antibodies (IFA) and the presence of pernicious anemia in a large cohort of primary biliary cirrhosis (PBC) ...