Listar por autor "Simos, G."
Mostrando ítems 41-60 de 69
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Increased HIF-1 alpha immunostaining in psoriasis compared to psoriasiform dermatitides
Ioannou, M.; Sourli, F.; Mylonis, I.; Barbanis, S.; Papamichali, R.; Kouvaras, E.; Zafiriou, E.; Siomou, P.; Klimi, E.; Simos, G.; Roussaki-Schulze, A. V.; Koukoulis, G. (2009)Background Expression of hypoxia inducible factor 1 (HIF-1) alpha can be linked to inflammation through reciprocal interactions with several cytokines. This finding is in accordance with the previously noted HIF-1 alpha ... -
The inflammatory mediator tumor necrosis factor alpha (TNF alpha) has cell type-dependent effects on hypoxia-inducible factor 1 (HIF-1)
Triantafyllou, E. A.; Tsapournioti, S.; Mylonis, I.; Simos, G.; Molyvdas, P. A.; Paraskeva, E. (2014) -
The intracellular location of two animoacyl-tRNA synthetases depends on complex formation with Arc1p
Galani, K.; Grosshans, H.; Deinert, K.; Hurt, E. C.; Simos, G. (2001)In yeast, two aminoacyl-tRNA synthetases, MetRS and GluRS, are associated with Arc1p. We have studied the mechanism of this complex formation and found that the non-catalytic N-terminally appended domains of MetRS and GluRS ... -
Investigation of hepcidin secretion in human hepatocytes
Chachami, G.; Braliou, G.; Paraskeva, E.; Simos, G. (2008) -
Isolation of hypoxia-inducible factor 1 (HIF-1) inhibitors from frankincense using a molecularly imprinted polymer
Lakka, A.; Mylonis, I.; Bonanou, S.; Simos, G.; Tsakalof, A. (2011)Hypoxia-Inducible Factor 1 (HIF-1), a transcriptional activator, is highly involved in the pathology of cancer. Inhibition of HIF-1 retards tumor growth and enhances treatment efficiency when used in combination with chemo- ... -
Lack of pseudouridine 38/39 in the anticodon arm of yeast cytoplasmic tRNA decreases in vivo recoding efficiency
Lecointe, F.; Namy, O.; Hatin, I.; Simos, G.; Rousset, J. P.; Grosjean, H. (2002)Many different modified nucleotides are found in naturally occurring tRNA, especially in the anticodon region. Their importance for the efficiency of the translational process begins to be well documented. Here we have ... -
Low Oxygen Tension Enhances Hepatitis C Virus Replication
Vassilaki, N.; Kalliampakou, K. I.; Kotta-Loizou, I.; Befani, C.; Liakos, P.; Simos, G.; Mentis, A. F.; Kalliaropoulos, A.; Doumba, P. P.; Smirlis, D.; Foka, P.; Bauhofer, O.; Poenisch, M.; Windisch, M. P.; Lee, M. E.; Koskinas, J.; Bartenschlager, R.; Mavromara, P. (2013)Low oxygen tension exerts a significant effect on the replication of several DNA and RNA viruses in cultured cells. In vitro propagation of hepatitis C virus (HCV) has thus far been studied under atmospheric oxygen levels ... -
Low Serum Hepcidin in Patients with Autoimmune Liver Diseases
Lyberopoulou, A.; Chachami, G.; Gatselis, N. K.; Kyratzopoulou, E.; Saitis, A.; Gabeta, S.; Eliades, P.; Paraskeva, E.; Zachou, K.; Koukoulis, G. K.; Mamalaki, A.; Dalekos, G. N.; Simos, G. (2015)Hepcidin, a liver hormone, is important for both innate immunity and iron metabolism regulation. As dysfunction of the hepcidin pathway may contribute to liver pathology, we analysed liver hepcidin mRNA and serum hepcidin ... -
MgcRacGAP interacts with HIF-1 alpha and regulates its transcriptional activity
Lyberopoulou, A.; Venieris, E.; Mylonis, I.; Chachami, G.; Pappas, I.; Simos, G.; Bonanou, S.; Georgatsou, E. (2007)HIF-1 alpha is the inducible subunit of the dimeric transcription factor HIF-1 (Hypoxia Inducible Factor 1). It is induced by hypoxia and hypoxia-mimetics in most cell types, as well as non-hypoxic signals such as growth ... -
MgcRacGAP, a cytoskeleton regulator, inhibits HIF-1 transcriptional activity by blocking its dimerization
Lyberopoulou, A.; Mylonis, I.; Papachristos, G.; Sagris, D.; Kalousi, A.; Befani, C.; Liakos, P.; Simos, G.; Georgatsou, E. (2013)Hypoxia inducible factor-1 (HIF-1), a dimeric transcription factor of the bHLH-PAS family, is comprised of HIF-1 alpha, which is inducible by hypoxia and ARNT or HIF-1 beta, which is constitutively expressed. HIF-1 is ... -
Molecular determinants of the yeast Arc1p - Aminoacyl-tRNA synthetase complex assembly
Karanasios, E.; Simader, H.; Panayotou, G.; Suck, D.; Simos, G. (2007)Eukaryotic aminoacyl-tRNA synthetases are usually organized into high-molecular-weight complexes, the structure and function of which are poorly understood. We have previously described a yeast complex containing two ... -
Oxygen-dependent secretion of a bioactive hepcidin-GFP chimera
Chachami, G.; Lyberopoulou, A.; Kalousi, A.; Paraskeva, E.; Pantopoulos, K.; Simos, G. (2013)Hepcidin, a hepatic hormone, regulates serum iron levels by controlling both intestinal iron absorption and iron release from macrophages. Although transcription of hepcidin is controlled by diverse stimuli, it remains ... -
Phosphorylation of the N-terminal domain of the human HIF-1 alpha
Kalousi, A.; Mylonis, I.; Simos, G. (2008) -
Pro-inflammatory cytokines TNF-alpha, IL-6 and IL-1 beta exhibit differential effects on the expression and transcriptional activity of HIFs in human liver cancer cells
Pangou, E.; Simos, G.; Liakos, P. (2014) -
Prognostic significance of Hypoxia-Inducible Factor 1 alpha(HIF-1alpha) expression in serous ovarian cancer: an immunohistochemical study
Daponte, A.; Ioannou, M.; Mylonis, I.; Simos, G.; Minas, M.; Messinis, I. E.; Koukoulis, G. (2008)Background: The hypoxia-inducible factor (HIF) has emerged as an attractive target for cancer therapy. The few publications addressing the prognostic significance of Hypoxia-Inducible Factor 1 alpha (HIF-1 alpha) cellular ... -
Pus1p-dependent tRNA Pseudouridinylation Becomes Essential When tRNA Biogenesis Is Compromised in Yeast
Großhans, H.; Lecointe, F.; Grosjean, H.; Hurt, E.; Simos, G. (2001)Yeast Pus1p catalyzes the formation of pseudouridine (ψ) at specific sites of several tRNAs, but its function is not essential for cell viability. We show here that Pus1p becomes essential when another tRNA: pseudouridine ... -
Reconstitution of human hypoxia inducible factor 1 (HIF-1) in yeast cells: a simple in vivo system to identify hif-1 inhibitors
Braliou, G. G.; Venieris, E.; Simos, G. (2005) -
Reconstitution of human hypoxia inducible factor HIF-1 in yeast: A simple in vivo system to identify and characterize HIF-1 alpha effectors
Braliou, G. G.; Venieris, E.; Kalousi, A.; Simos, G. (2006)Hypoxia inducible factor I (HIF-1), the master regulator of hypoxia-activated genes, is involved in many diseases and is a valid drug target. In order to develop a simple and genetically tractable in vivo system for HIF-1 ... -
Regulation of HIF-1alpha activity in airway smooth muscle cells: the role of cobalt and serum
Chachami, G.; Simos, G.; Bonanou, S.; Molyvdas, P. A.; Paraskeva, E. (2005)