• External Validation of the PREMISE Score in the Athens Stroke Registry 

      Ntaios G., Georgiopoulos G., Koroboki E., Vemmos K. (2019)
      Background: A simple score was proposed recently for Predicting Early Mortality from Ischemic Stroke (PREMISE) derived from the Austrian Stroke Unit Registry. This score could be useful in clinical practice and research. ...
    • Focal hypoperfusion in acute ischemic stroke perfusion CT: Clinical and radiologic predictors and accuracy for infarct prediction 

      Bill O., Inácio N.M., Lambrou D., Wintermark M., Ntaios G., Dunet V., Michel P. (2019)
      BACKGROUND AND PURPOSE: Perfusion CT may improve the diagnostic performance of noncontrast CT in acute ischemic stroke. We assessed predictors of focal hypoperfusion in acute ischemic stroke and perfusion CT performance ...
    • Hormonal contraceptives and risk of ischemic stroke in women with migraine: a consensus statement from the European Headache Federation (EHF) and the European Society of Contraception and Reproductive Health (ESC) 

      Sacco S., Merki-Feld G.S., Ægidius K.L., Bitzer J., Canonico M., Kurth T., Lampl C., Lidegaard Ø., Anne MacGregor E., MaassenVanDenBrink A., Mitsikostas D.-D., Nappi R.E., Ntaios G., Sandset P.M., Martelletti P., on behalf of the European Headache Federation (EHF) and the European Society of Contraception and Reproductive Health (ESC) (2017)
      Several data indicate that migraine, especially migraine with aura, is associated with an increased risk of ischemic stroke and other vascular events. Of concern is whether the risk of ischemic stroke in migraineurs is ...
    • Intravenous Thrombolysis in Patients With Ischemic Stroke Aged ≥90 Years: A Cohort Study From the TRISP Collaboration 

      Altersberger V.L., Rusche N., Martinez-Majander N., Hametner C., Scheitz J.F., Henon H., Dell'acqua M.L., Strambo D., Stolp J., Heldner M.R., Grisendi I., Jovanovic D.R., Bejot Y., Pezzini A., Leker R.R., Kägi G., Wegener S., Cereda C.W., Lindgren E., Ntaios G., Piot I., Polymeris A.A., Lyrer P.A., Räty S., Sibolt G., Tiainen M., Heyse M., Erdur H., Kaaouana O., Padjen V., Zedde M., Arnold M., Nederkoorn P.J., Michel P., Bigliardi G., Zini A., Cordonnier C., Nolte C.H., Ringleb P.A., Curtze S., Engelter S.T., Gensicke H., for the Thrombolysis in Stroke Patients (TRISP) Collaborators (2022)
      Background: The probability to receive intravenous thrombolysis (IVT) for treatment of acute ischemic stroke declines with increasing age and is consequently the lowest in very elderly patients. Safety concerns likely ...
    • Lateralization of Insular Ischemic Stroke is Not Associated With Any Stroke Clinical Outcomes: The Athens Stroke Registry 

      Vassilopoulou S., Korompoki E., Tountopoulou A., Mitsikostas D.D., Manios E., Georgiopoulos G., Ntaios G., Milionis H., Fontara S., Vemmos K. (2020)
      Background: Controversial evidence suggests that right insular stroke may be associated with worse outcomes compared to the left insular ischemic lesion. Objectives: We investigated whether lateralization of insular stroke ...
    • Lipoprotein(a) is associated with large artery atherosclerosis stroke aetiology and stroke recurrence among patients below the age of 60 years: Results from the BIOSIGNAL study 

      Arnold M., Schweizer J., Nakas C.T., Schütz V., Westphal L.P., Inauen C., Pokorny T., Luft A., Leichtle A., Arnold M., Bicvic A., Fischer U., De Marchis G.M., Bonati L.H., Müller M.D., Kahles T., Nedeltchev K., Cereda C.W., Kägi G., Bustamante A., Montaner J., Ntaios G., Foerch C., Spanaus K., Von Eckardstein A., Katan M. (2021)
      Aims: Lipoprotein(a) [Lp(a)] is a recognized causal risk factor for atherosclerotic cardiovascular disease but its role for acute ischaemic stroke (AIS) is controversial. In this study, we evaluated the association of Lp(a) ...
    • Methodological assessment of guidelines for the diagnosis and management of cerebral vasospasm using the AGREE-II tool 

      Tasiou A., Brotis A.G., Tzerefos C., Lambrianou X., Fountas K.N. (2022)
      OBJECTIVE Rupture of an intracranial aneurysm is the most common cause of spontaneous subarachnoid hemorrhage. Despite the recent advances in its early detection, diagnosis, and proper treatment, the outcome of patients ...
    • Nonvitamin-K-antagonist oral anticoagulants versus warfarin in patients with atrial fibrillation and previous stroke or transient ischemic attack: An updated systematic review and meta-analysis of randomized controlled trials 

      Ntaios G., Papavasileiou V., Diener H.-C., Makaritsis K., Michel P. (2017)
      Background: In a previous systematic review and meta-analysis, we assessed the efficacy and safety of nonvitamin-K antagonist oral anticoagulants versus warfarin in patients with atrial fibrillation and stroke or transient ...
    • Predictors of Recurrent Ischemic Stroke in Patients with Embolic Strokes of Undetermined Source and Effects of Rivaroxaban Versus Aspirin According to Risk Status: The NAVIGATE ESUS Trial 

      Hart R.G., Veltkamp R.C., Sheridan P., Sharma M., Kasner S.E., Bangdiwala S.I., Ntaios G., Shoamanesh A., Ameriso S.F., Toni D., Czlonkowska A., Lindgren A., Hankey G.J., Perera K.S., Shuaib A., Coutts S.B., Gagliardi R.J., Berkowitz S.D., Mundl H., Peters G., Connolly S.J., NAVIGATE ESUS Investigators (2019)
      Background: Embolic stroke of undetermined source (ESUS) identifies patients with cryptogenic ischemic stroke presumed due to embolism from several unidentified sources. Among patients with recent ESUS, we sought to determine ...
    • Real-World Setting Comparison of Nonvitamin-K Antagonist Oral Anticoagulants Versus Vitamin-K Antagonists for Stroke Prevention in Atrial Fibrillation: A Systematic Review and Meta-Analysis 

      Ntaios G., Papavasileiou V., Makaritsis K., Vemmos K., Michel P., Lip G.Y.H. (2017)
      Background and Purpose - Evidence from the real-world setting complements evidence coming from randomized controlled trials. We aimed to summarize all available evidence from high-quality real-world observational studies ...
    • Recommendations for lipid modification in patients with ischemic stroke or transient ischemic attack: A clinical guide by the Hellenic Stroke Organization and the Hellenic Atherosclerosis Society 

      Sagris D., Ntaios G., Georgiopoulos G., Kakaletsis N., Elisaf M., Katsiki N., Korompoki E., Kypreos K.E., Boutari C., Bilianou H., Makaritsis K., Nomikos T., Papavasileiou V., Pitsavos C., Plomaritoglou A., Spengos K., Tziomalos K., Tselepis A., Vemmos K., Liberopoulos E., Milionis H. (2021)
      This document presents the consensus recommendations of the Hellenic Stroke Organization and the Hellenic Atherosclerosis Society for lipid modification in patients with ischemic stroke or transient ischemic attack. This ...
    • Recommendations for Mechanical Thrombectomy in Patients with Acute Ischemic Stroke: A Clinical Guide by the Hellenic Stroke Organization 

      Papanagiotou P., Ntaios G., Papavasileiou V., Psychogios K., Psychogios M., Mpotsaris A., Rizos T., Spengos K., Gravanis M., Vassilopoulou S., Gkogkas C., Zampakis P., Zis P., Karantanas A., Karygiannis M., Karydas G., Korompoki E., Makaritsis K., Marmagkiolis K., Milionis H., Mitsikostas D., Nikas D., Plomaritoglou A., Politi M., Ptochis N., Savopoulos C., Takis K., Tsamopoulos N., Tsetis D., Hatzidakis A., Chatziioannou A., Hatzitolios A., Vemmos K. (2018)
      This document presents the consensus recommendations of the Hellenic Stroke Organization which can be of assistance to the treating stroke physicians. © 2017, Springer-Verlag GmbH Germany.
    • Recurrent Ischemic Stroke and Bleeding in Patients With Atrial Fibrillation Who Suffered an Acute Stroke While on Treatment With Nonvitamin K Antagonist Oral Anticoagulants: The RENO-EXTEND Study 

      Paciaroni M., Caso V., Agnelli G., Mosconi M.G., Giustozzi M., Seiffge D.J., Engelter S.T., Lyrer P., Polymeris A.A., Kriemler L., Zietz A., Putaala J., Strbian D., Tomppo L., Michel P., Strambo D., Salerno A., Remillard S., Buehrer M., Bavaud O., Vanacker P., Zuurbier S., Yperzeele L., Loos C.M.J., Cappellari M., Emiliani A., Zedde M., Abdul-Rahim A., Dawson J., Cronshaw R., Schirinzi E., Del Sette M., Stretz C., Kala N., Reznik M., Schomer A., Grory B.M., Jayaraman M., Mctaggart R., Yaghi S., Furie K.L., Masotti L., Grifoni E., Toni D., Risitano A., Falcou A., Petraglia L., Lotti E.M., Padroni M., Pavolucci L., Lochner P., Silvestrelli G., Ciccone A., Alberti A., Venti M., Traballi L., Urbini C., Kargiotis O., Rocco A., Diomedi M., Marcheselli S., Caliandro P., Zauli A., Reale G., Antonenko K., Rota E., Tassinari T., Saia V., Palmerini F., Aridon P., Arnao V., Monaco S., Cottone S., Baldi A., D'Amore C., Ageno W., Pegoraro S., Ntaios G., Sagris D., Giannopoulos S., Kosmidou M., Ntais E., Romoli M., Pantoni L., Rosa S., Bertora P., Chiti A., Canavero I., Saggese C.E., Plocco M., Giorli E., Palaiodimou L., Bakola E., Tsivgoulis G., Bandini F., Gasparro A., Terruso V., Mannino M., Pezzini A., Ornello R., Sacco S., Popovic N., Scoditti U., Genovese A., Denti L., Flomin Y., Mancuso M., Ferrari E., Caselli M.C., Ulivi L., Giannini N., De Marchis G.M. (2022)
      BACKGROUND: In patients with atrial fibrillation who suffered an ischemic stroke while on treatment with nonvitamin K antagonist oral anticoagulants, rates and determinants of recurrent ischemic events and major bleedings ...
    • Risk Stratification for Recurrence and Mortality in Embolic Stroke of Undetermined Source 

      Ntaios G., Vemmos K., Lip G.Y.H., Koroboki E., Manios E., Vemmou A., Rodríguez-Campello A., Cuadrado-Godia E., Giralt-Steinhauer E., Arnao V., Caso V., Paciaroni M., Diez-Tejedor E., Fuentes B., Pérez Lucas J., Arauz A., Ameriso S.F., Hawkes M.A., Pertierra L., Gómez-Schneider M., Bandini F., Chavarria Cano B., Iglesias Mohedano A.M., García Pastor A., Gil-Núñez A., Putaala J., Tatlisumak T., Barboza M.A., Athanasakis G., Makaritsis K., Papavasileiou V. (2016)
      Background and Purpose - The risk of stroke recurrence in patients with Embolic Stroke of Undetermined Source (ESUS) is high, and the optimal antithrombotic strategy for secondary prevention is unclear. We investigated ...
    • Rivaroxaban for stroke prevention after embolic stroke of undetermined source 

      Hart R.G., Sharma M., Mundl H., Kasner S.E., Bangdiwala S.I., Berkowitz S.D., Swaminathan B., Lavados P., Wang Y., Wang Y., Davalos A., Shamalov N., Mikulik R., Cunha L., Lindgren A., Arauz A., Lang W., Czlonkowska A., Eckstein J., Gagliardi R.J., Amarenco P., Ameriso S.F., Tatlisumak T., Veltkamp R., Hankey G.J., Toni D., Bereczki D., Uchiyama S., Ntaios G., Yoon B.-W., Brouns R., Endres M., Muir K.W., Bornstein N., Ozturk S., O'Donnell M.J., De Vries Basson M.M., Pare G., Pater C., Kirsch B., Sheridan P., Peters G., Weitz J.I., Peacock W.F., Shoamanesh A., Benavente O.R., Joyner C., Themeles E., Connolly S.J., for the NAVIGATE ESUS Investigators (2018)
      BACKGROUND Embolic strokes of undetermined source represent 20% of ischemic strokes and are associated with a high rate of recurrence. Anticoagulant treatment with rivaroxaban, an oral factor Xa inhibitor, may result in a ...
    • Safety of Anticoagulation in Patients Treated with Urgent Reperfusion for Ischemic Stroke Related to Atrial Fibrillation 

      Giustozzi M., Acciarresi M., Agnelli G., Caso V., Bandini F., Tsivgoulis G., Yaghi S., Furie K.L., Tadi P., Becattini C., Zedde M., Abdul-Rahim A.H., Lees K.R., Alberti A., Venti M., D'Amore C., Giulia Mosconi M., Anna Cimini L., Bovi P., Carletti M., Rigatelli A., Cappellari M., Putaala J., Tomppo L., Tatlisumak T., Marcheselli S., Pezzini A., Poli L., Padovani A., Vannucchi V., Sohn S.-I., Lorenzini G., Tassi R., Guideri F., Acampa M., Martini G., Ntaios G., Athanasakis G., Makaritsis K., Karagkiozi E., Vadikolias K., Liantinioti C., Theodorou A., Halvatsiotis P., Mumoli N., Galati F., Sacco S., Tiseo C., Corea F., Ageno W., Bellesini M., Silvestrelli G., Ciccone A., Lanari A., Scoditti U., Denti L., Mancuso M., Ferrari E., Ulivi L., Orlandi G., Giannini N., Tassinari T., Luisa De Lodovici M., Rueckert C., Baldi A., Toni D., Letteri F., Giuntini M., Maria Lotti E., Flomin Y., Pieroni A., Kargiotis O., Karapanayiotides T., Monaco S., Maimone Baronello M., Csiba L., Szabó L., Chiti A., Giorli E., Del Sette M., Imberti D., Zabzuni D., Doronin B., Volodina V., Michel P., Vanacker P., Barlinn K., Barlinn J., Deleu D., Gourbali V., Paciaroni M., Masotti L. (2020)
      Background and Purpose: The optimal timing for starting oral anticoagulant after an ischemic stroke related to atrial fibrillation remains a challenge, mainly in patients treated with systemic thrombolysis or mechanical ...
    • A score to predict one-year risk of recurrence after acute ischemic stroke 

      Strambo D., Zachariadis A., Lambrou D., Schwarz G., Sirimarco G., Aarnio K., Putaala J., Ntaios G., Vemmos K., Michel P. (2021)
      Background: An acute ischemic stroke carries a substantial risk of further recurrences. We aimed at developing and validating a prognostic tool to predict one-year stroke recurrence after acute ischemic stroke. Methods: ...
    • Searching for Atrial Fibrillation Poststroke: A White Paper of the AF-SCREEN International Collaboration 

      Schnabel R.B., Haeusler K.G., Healey J.S., Freedman B., Boriani G., Brachmann J., Brandes A., Bustamante A., Casadei B., Crijns H.J.G.M., Doehner W., Engström G., Fauchier L., Friberg L., Gladstone D.J., Glotzer T.V., Goto S., Hankey G.J., Harbison J.A., Hobbs F.D.R., Johnson L.S.B., Kamel H., Kirchhof P., Korompoki E., Krieger D.W., Lip G.Y.H., Løchen M.-L., Mairesse G.H., Montaner J., Neubeck L., Ntaios G., Piccini J.P., Potpara T.S., Quinn T.J., Reiffel J.A., Ribeiro A.L.P., Rienstra M., Rosenqvist M., Sakis T., Sinner M.F., Svendsen J.H., Van Gelder I.C., Wachter R., Wijeratne T., Yan B. (2019)
      Cardiac thromboembolism attributed to atrial fibrillation (AF) is responsible for up to one-third of ischemic strokes. Stroke may be the first manifestation of previously undetected AF. Given the efficacy of oral anticoagulants ...
    • Statin-based therapy for primary and secondary prevention of ischemic stroke: A meta-analysis and critical overview 

      Milionis H., Ntaios G., Korompoki E., Vemmos K., Michel P. (2020)
      Background and aims: To reassess the effect of statin-based lipid-lowering therapy on ischemic stroke in primary and secondary prevention trials with regard to achieved levels of low-density lipoprotein-cholesterol in view ...
    • Supracardiac atherosclerosis in embolic stroke of undetermined source: The underestimated source 

      Ntaios G., Wintermark M., Michel P. (2021)
      The term ‘embolic stroke of undetermined source’ (ESUS) is used to describe patients with a non-lacunar ischaemic stroke without any identified embolic source from the heart or the arteries supplying the ischaemic territory, ...