Auflistung nach Autor "Speletas, M."
Anzeige der Dokumente 21-40 von 61
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Genetic analysis of C5a receptors in neutrophils from patients with familial Mediterranean fever
Apostolidou, E.; Kambas, K.; Chrysanthopoulou, A.; Kourtzelis, I.; Speletas, M.; Ritis, K.; Mitroulis, I. (2012)Familial Mediterranean fever (FMF) is an autoinflammatory disease, characterized by MEFV gene mutations and self-limited recurrent episodes of fever and localized serositis. Complement system is a key regulator of the ... -
Genetic polymorphisms of innate and adaptive immunity as predictors of outcome in critically ill patients
Kompoti, M.; Michopoulos, A.; Michalia, M.; Clouva-Molyvdas, P. M.; Germenis, A. E.; Speletas, M. (2015)Sepsis and septic shock frequently cause the admission or complicate the clinical course of critically ill patients admitted in the intensive care units (ICU). Genetic variations disrupting the immune sensing of infectious ... -
Hereditary angioedema in Greek families caused by novel and recurrent mutations
Speletas, M.; Boukas, K.; Papadopoulou-Alataki, E.; Tsitsami, E.; Germenis, A. E. (2009)This study constitutes the first molecular analysis of hereditary angioedema (HAE) in Greece, where 11 patients from three unrelated families with recurrent angioedema attacks and decreased C1 inhibitor antigenic levels ... -
Hereditary angioedema: Molecular and clinical differences among European populations
Speletas, M.; Szilagyi, A.; Psarros, F.; Moldovan, D.; Magerl, M.; Kompoti, M.; Gramoustianou, E.; Bors, A.; Mihaly, E.; Tordai, A.; Avramouli, A.; Varga, L.; Maurer, M.; Farkas, H.; Germenis, A. E. (2015) -
Hereditary hyperferritinemia cataract syndrome as a cause of childhood hyperferritinemia
Tsantoula, F.; Kioumi, A.; Germenis, A. E.; Speletas, M. (2014)A 2-year-old female was presented with high levels of serum ferritin (890 ng/mL) in a routine blood test. Clinical and laboratory investigations excluded the presence of iron overload and secondary causes of hyperferritinemia. ... -
Heterozygous Alterations of TNFRSF13B/TACI in Tonsillar Hypertrophy and Sarcoidosis
Speletas, M.; Salzer, U.; Florou, Z.; Petinaki, E.; Daniil, Z.; Bardaka, F.; Gourgoulianis, K. I.; Skoulakis, C.; Germenis, A. E. (2013)TNFRSF13B/TACI defects have been associated with CVID pathogenesis and/or phenotype, especially the development of benign lymphoproliferation and autoimmunity. Our purpose was to investigate the role of TNFRSF13B/TACI ... -
Identification of a STAT5 Target Gene, Dpf3, Provides Novel Insights in Chronic Lymphocytic Leukemia
Theodorou, M.; Speletas, M.; Mamara, A.; Papachristopoulou, G.; Lazou, V.; Scorilas, A.; Katsantoni, E. (2013)STAT5 controls essential cellular functions and is encoded by two genes, Stat5a and Stat5b. To provide insight to the mechanisms linking hematologic malignancy to STAT5 activation/regulation of target genes, we identified ... -
IGA ANTIBODIES AGAINST DEAMIDATED GLIADIN PEPTIDES AND TISSUE-TRANSGLUTAMINASE IN PATIENTS WITH CHRONIC LIVER DISEASES
Gatselis, N. K.; Zachou, K.; Norman, G. L.; Tzelas, G.; Gabeta, S.; Speletas, M.; Koukoulis, G. K.; Dalekos, G. N. (2012) -
IgA antibodies against deamidated gliadin peptides in patients with chronic liver diseases
Gatselis, N. K.; Zachou, K.; Norman, G. L.; Tzellas, G.; Speletas, M.; Gabeta, S.; Germenis, A.; Koukoulis, G. K.; Dalekos, G. N. (2012)Background/aims: IgA antibodies against tissue-transglutaminase (anti-tTG-IgA) and IgA and IgG antibodies against deamidated gliadin peptides (anti-DGP-IgA and anti-DGP-IgG) are considered specific for celiac disease (CD) ... -
In vivo induction of the autophagic machinery in human bone marrow cells during Leishmania donovani complex infection
Mitroulis, I.; Kourtzelis, I.; Papadopoulos, V. P.; Mimidis, K.; Speletas, M.; Ritis, K. (2009)Autophagy is a homeostatic process promoting cell survival in periods of stress. The induction of the autophagic machinery has also been implicated in both innate and adaptive immunity. Leishmania donovani, which is the ... -
Influence of common thrombophilia polymorphisms on the thrombosis risk in patients with JAK2-V617F-positive myeloproliferative neoplasms
Giamouris, V.; Befani, M.; Papadakis, E.; Mandala, E.; Papadoulis, N.; Karamagiolis, S.; Gastari, V.; Verrou, E.; Katodritou, E.; Lafioniatis, S.; Kartasis, Z.; Magiannis, K.; Marinaki, P.; Tsioni, K.; Kioumi, A.; Germenis, A. E.; Speletas, M. (2012) -
Influence of mannose-binding lectin (MBL) deficiency on the clinical presentation of patients with antibody deficiencies
Speletas, M.; Iordanakis, G.; Mamara, A.; Florou, Z.; Papadopoulou-Alataki, E.; Germenis, A. E. (2012) -
JAK2 V617F-POSITIVE CHRONIC EOSINOPHILIC LEUKEMIA: CLINICAL, LABORATORY AND MOLECULAR DEFINITION OF A DISTINCT DISEASE SUBTYPE
Zoi, K.; Dahabreh, I. J.; Zoi, C.; Helbig, G.; Krzemien, S.; Gota, V.; Speletas, M.; Giannouli, S.; Palliou, A.; Stefanoudaki, K.; Harhalakis, N.; Vassilopoulos, G.; Kotsopoulou, M.; Tsirigotis, P.; Moutsopoulos, H. M.; Loukopoulos, D.; Voulgarelis, M. (2009) -
Leptin induces the expression of functional tissue factor in human neutrophils and peripheral blood mononuclear cells through JAK2-dependent mechanisms and TNF alpha involvement
Rafail, S.; Ritis, K.; Schaefer, K.; Kourtzelis, I.; Speletas, M.; Doumas, M.; Giaglis, S.; Kambas, K.; Konstantinides, S.; Kartalis, G. (2008)Introduction: Leptin is an adipocyte-derived cytokine primarily involved in the regulation of body weight and energy balance. In vivo studies suggest that leptin promotes platelet aggregation and thrombosis. Neutrophils ... -
Liver FOXP3 and PD1/PDL1 expression is down-regulated in chronic HBV hepatitis on maintained remission related to the degree of inflammation
Germanidis, G.; Argentou, N.; Hytiroglou, P.; Vassiliadis, T.; Patsiaoura, K.; Germenis, A. E.; Speletas, M. (2013)Background and Aim: T cell expression of PD1 and inhibition of T effector cells by Foxp3(+)-T regulatory cells are among the most powerful mechanisms for achieving a balanced immune response. Our aim was to investigate, ... -
LIVER PD-1/PDL-1/PD-L2 MRNA EXPRESSION QUANTITATIVE ANALYSIS IN PATIENTS WITH CHRONIC HBV AND HCV HEPATITIS
Argentou, N.; Germanidis, G.; Vassiliadis, T.; Patsiaura, K.; Mantzoukis, K.; Ritis, K.; Eleftheriadis, D.; Evgenidis, N.; Nikolaidis, P.; Germenis, A. E.; Speletas, M. (2010) -
MBL2 Genotypes and Their Associations with MBL Levels and NICU Morbidity in a Cohort of Greek Neonates
Speletas, M.; Gounaris, A.; Sevdali, E.; Kompoti, M.; Konstantinidi, K.; Sokou, R.; Tsitsami, E.; Germenis, A. E. (2015)The objective of this study was to assess the frequency of MBL2 genotypes and their associations with MBL levels and various morbidities of a neonatal intensive care unit (NICU). One hundred and thirty-four (134) NICU (83 ... -
MEFV alterations and population genetics analysis in a large cohort of Greek patients with familial Mediterranean fever
Giaglis, S.; Papadopoulos, V.; Kambas, K.; Doumas, M.; Tsironidou, V.; Rafail, S.; Kartalis, G.; Speletas, M.; Ritis, K. (2007)Familial Mediterranean fever (FMF) is a disease characterized by recurrent, self-limiting bouts of fever and serositis and caused by altered pyrin due to mutated MEFV gene. FMF is common in the Mediterranean Basin populations, ... -
Methylation status of RASSF1A in patients with chronic myeloid leukemia
Avramouli, A.; Tsochas, S.; Mandala, E.; Katodritou, E.; Ioannou, M.; Ritis, K.; Speletas, M. (2009)RASSF1A, a key cell cycle related gene, is expressed in all hematopoietic cells, it is implicated in ras signaling pathway and its promoter hypermethylation is observed in a wide variety of solid tumors. Till now, RASSF1A ... -
Overexpression of SMAD7 protects liver from TGFb/Smad-mediated fibrogenesis
Argentou, N.; Germanidis, G.; Apostolou, E.; Vasiliadis, T.; Sideras, P.; Germenis, A. E.; Speletas, M. (2012)