Πλοήγηση ανά Συγγραφέα "Komiotis, D."
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Efficient synthesis of exomethylene- and keto-exomethylene-D-glucopyranosyl nucleoside analogs as potential cytotoxic agents
Tzioumaki, N.; Tsoukala, E.; Manta, S.; Kiritsis, C.; Balzarini, J.; Komiotis, D. (2011)A novel series of exomethylene- and keto-exomethylene-D-glucopyranonucleosides with thymine, uracil, and 5-fluorouracil as heterocyclic bases have been designed and synthesized. Wittig condensation of the 3-keto glucoside ... -
Exomethylene pyranonucleosides: Efficient synthesis and biological evaluation of 1-(2,3,4-trideoxy-2-methylene-beta-D-glycero-hex-3-enopyranosyl)thymine
Agelis, G.; Tzioumaki, N.; Boti, T.; Cencic, A. A.; Komiotis, D. (2007)A new series of unsaturated pyranonucleosides with an exocyclic methylene group and thymine as heterocyclic base have been designed and synthesized. D-Galactose (1) was readily transformed in three steps into the corresponding ... -
A facile, one-step conversion of 6-O-trityl and 6-O-TBDMS monosaccharides into the corresponding formate esters
Komiotis, D.; Agelis, G.; Manta, S.; Tzioumaki, N.; Tsoukala, E.; Antonakis, K. (2006)A convenient method has been developed for a facile and high-yield conversion of 6-O-tertbutyldimethylsilyl and 6-O-trityl protected monosaccharides to their formate esters, which may serve as useful intermediates for the ... -
Fluoro-ketopyranosyl nucleosides: Synthesis and biological evaluation of 3-fluoro-2-keto-beta-D-glucopyranosyl derivatives of N-4-benzoyl cytosine
Manta, S.; Agelis, G.; Botic, T.; Cencic, A.; Komiotis, D. (2007)1,2:5,6-Di-O-isopropylidene-ot-D-glucofuranose on mild oxidation, reduction, fluorination, and deisopropylidenation followed by acetylation gave peracetylated 3-deoxy-3-fluoro-D-glueopyranose. This was coupled with silylated ... -
Genome analysis of two type 6 echovirus (E6) strains recovered from sewage specimens in Greece in 2006
Kyriakopoulou, Z.; Pliaka, V.; Tsakogiannis, D.; Ruether, I. G. A.; Komiotis, D.; Gartzonika, C.; Levidiotou-Stefanou, S.; Markoulatos, P. (2012)Echovirus 6 (E6) is one of the main enteroviral serotypes that was isolated from cases of aseptic meningitis and encephalitis during the last years in Greece. Two E6 (LR51A5 and LR61G3) were isolated from the sewage treatment ... -
Glycogen Phosphorylase as a Target for Type 2 Diabetes: Synthetic, Biochemical, Structural and Computational Evaluation of Novel N-acyl-N '-(beta-D-glucopyranosyl) Urea Inhibitors
Kantsadi, A. L.; Parmenopoulou, V.; Bakalov, D. N.; Snelgrove, L.; Stravodimos, G. A.; Chatzileontiadou, D. S. M.; Manta, S.; Panagiotopoulou, A.; Hayes, J. M.; Komiotis, D.; Leonidas, D. D. (2015)Glycogen phosphorylase (GP), a validated target for the development of anti-hyperglycaemic agents, has been targeted for the design of novel glycopyranosylamine inhibitors. Exploiting the two most potent inhibitors from ... -
Glycogen phosphorylase as a target for type 2 diabetes: Synthetic, biochemical, structural and computational evaluation of novel N-acyl-N´-(β-D-glucopyranosyl) urea inhibitors
Kantsadi, A. L.; Parmenopoulou, V.; Bakalov, D. N.; Snelgrove, L.; Stravodimos, G. A.; Chatzileontiadou, D. S. M.; Manta, S.; Panagiotopoulou, A.; Hayes, J. M.; Komiotis, D.; Leonidas, D. D. (2015)Glycogen phosphorylase (GP), a validated target for the development of anti-hyperglycaemic agents, has been targeted for the design of novel glycopyranosylamine inhibitors. Exploiting the two most potent inhibitors from ... -
An Integrated In Silico Approach to Design Specific Inhibitors Targeting Human Poly(A)-Specific Ribonuclease
Vlachakis, D.; Pavlopoulou, A.; Tsiliki, G.; Komiotis, D.; Stathopoulos, C.; Balatsos, N. A. A.; Kossida, S. (2012)Poly(A)-specific ribonuclease (PARN) is an exoribonuclease/deadenylase that degrades 3'-end poly(A) tails in almost all eukaryotic organisms. Much of the biochemical and structural information on PARN comes from the human ... -
Keto and Exomethylene Pyranonucleosides as Antitumor Agents
Tsoukala, E.; Manta, S.; Kiritsis, C.; Komiotis, D. (2012)Nucleosides and their analogues take an important place in medicinal chemistry as the structural basis for the development of therapeutic agents. Recently, there has been a renewed interest in the synthesis of keto and ... -
Keto-fluorothiopyranosyl nucleosides: a convenient synthesis of 2-and 4-keto-3-fluoro-5-thioxylopyranosyl thymine analogs
Tsoukala, E.; Manta, S.; Tzioumaki, N.; Kiritsis, C.; Komiotis, D. (2011)A novel series of fluorinated keto-beta-D-5-thioxylopyranonucleosides bearing thymine as the heterocyclic base have been designed and synthesized. Deprotection of 3-deoxy-3-fluoro-5-S-acetyl-5-thio-D-xylofuranose (1) and ... -
Kinetic and in silico analysis of the slow-binding inhibition of human poly(A)-specific ribonuclease (PARN) by novel nucleoside analogues
Balatsos, N.; Vlachakis, D.; Chatzigeorgiou, V.; Manta, S.; Komiotis, D.; Vlassi, M.; Stathopoulos, C. (2012)Poly(A)-specific ribonuclease (PARN) is a 3'-exoribonuclease that efficiently degrades poly(A) tails and regulates, in part, mRNA turnover rates. We have previously reported that adenosine- and cytosine-based glucopyranosyl ... -
N-substituted Pyrrole-based Scaffolds as Potential Anticancer and Antiviral Lead Structures
Pegklidou, K.; Papastavrou, N.; Gkizis, P.; Komiotis, D.; Balzarini, J.; Nicolaou, I. (2015)Undoubtedly, efficient cancer treatment has been a significant challenge for the scientific community over the last decades. Despite tremendous progress made towards this direction, there are still efforts needed to discover ... -
A new bifunctional tridentate NSN ligand leading to cationic tricarbonyl fac- M(NSN)(CO)(3) (+) (M = Re, Tc-99m) complexes
Mylonas, I.; Triantis, C.; Panagiotopoulou, A.; Patsis, G.; Raptopoulou, C. P.; Terzis, A.; Psycharis, V.; Komiotis, D.; Pelecanou, M.; Pirmettis, I.; Papadopoulos, M. (2013)The synthesis and characterization of the new NSN tridentate bifunctional chelating agent 3-[2-(2'-pyridin-2-yl-ethylsulfanyl)ethylamino] propionic acid (as its hydrochloric salt, 1) and of its corresponding rhenium comp ... -
New short route to unsaturated fluoroketonucleosides: Case of 5-fluoro-1-(6-0-acetyl-3,4-di-deoxy-3-fluoro-β-D-glycero-hex-3-eno-pyranos- 2-ulosyl) uracil
Egron, M. J.; Komiotis, D.; Dorange, I.; Herscovici, J.; Ollapally, A. P.; Antonakis, K. (2005)The proposed short synthesis involves two key steps: Oxidation of the isopropylidene derivative of the 3-fluoronucleoside possessing a free hydroxyl group in 2-position and acetylation of deprotected 3-fluoro-2-ketonucleoside ... -
New short route to unsaturated fluoroketonucleosides: Case of 5-fluoro-1-(6-O-acetyl-3,4-di-deoxy-3-fluoro-beta-D-glycero-hex-3-eno-py ranos-2-ulosyl) uracil
Egron, M. J.; Komiotis, D.; Dorange, I.; Herscovici, J.; Ollapally, A. P.; Antonakis, K. (2005)The proposed short synthesis involves two key steps: Oxidation of the isopropylidene derivative of the 3 fluoronucleoside possessing a free hydroxyl group in 2-position and acetylation of deprotected 3-fluoro-2-ketonucleoside ... -
A novel and easy two-step, microwave-assisted method for the synthesis of halophenyl pyrrolo 2,3-b quinoxalines via their pyrrolo precursors. Evaluation of their bioactivity
Manta, S.; Gkaragkouni, D. N.; Kaffesaki, E.; Gkizis, P.; Hadjipavlou-Litina, D.; Pontiki, E.; Balzarini, J.; Dehaen, W.; Komiotis, D. (2014)A novel, two-step, facile route for the synthesis of pyrrolo[2,3-b]quinoxalines via 2,3-dioxopyrroles, enhanced by microwave irradiation, is presented. The newly synthesized 2,3-dioxo-5-halophenyl pyrrolo precursors 4a-c ... -
Rapid microwave-enhanced synthesis of C5-alkynyl pyranonucleosides as novel cytotoxic antitumor agents
Dimopoulou, A.; Manta, S.; Kiritsis, C.; Gkaragkouni, D. N.; Papasotiriou, I.; Balzarini, J.; Komiotis, D. (2013)A microwave-assisted, one-pot, coupling reaction for the synthesis of C5-alkynyl-uracil and cytosine glucopyranonucleosides has been developed. The reaction is carried out under standard Sonogashira coupling conditions ... -
Retrospective characterization of a vaccine-derived poliovirus type 1 isolate from sewage in greece
Dedepsidis, E.; Kyriakopoulou, Z.; Pliaka, V.; Kottaridi, C.; Bolanaki, E.; Levidiotou-Stefanou, S.; Komiotis, D.; Markoulatos, P. (2007)Retrospective molecular and phenotypic characterization of a vaccine-derived poliovirus (VDPV) type 1 isolate (7/b/97) isolated from sewage in Athens, Greece, in 1997 is reported. VP1 sequencing of this isolate revealed ... -
The role of AP-1 in colon cancer stem cells
Chatziioannou, M.; Apostolou, P.; Toloudi, M.; Ioannou, E.; Kopic, A.; Komiotis, D.; Papasotiriou, I. (2013) -
The s-Hole Phenomenon of Halogen Atoms Forms the Structural Basis of the Strong Inhibitory Potency of C5 Halogen Substituted Glucopyranosyl Nucleosides towards Glycogen Phosphorylase b
Kantsadi, A. L.; Hayes, J. M.; Manta, S.; Skamnaki, V. T.; Kiritsis, C.; Psarra, A. M. G.; Koutsogiannis, Z.; Dimopoulou, A.; Theofanous, S.; Nikoleousakos, N.; Zoumpoulakis, P.; Kontou, M.; Papadopoulos, G.; Zographos, S. E.; Komiotis, D.; Leonidas, D. D. (2012)C5 halogen substituted glucopyranosyl nucleosides (1-(beta-D-glucopyranosyl)-5-X-uracil; X=Cl, Br, I) have been discovered as some of the most potent active site inhibitors of glycogen phosphorylase (GP), with respective ...