Browsing by Author "Simos, G."
Now showing items 1-20 of 69
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2-Oxoglutarate-dependent oxygenases control hepcidin gene expression
Braliou, G. G.; Falzacappa, M. V. V.; Chachami, G.; Casanovas, G.; Muckenthaler, M. U.; Simos, G. (2008)Background/Aims: Hepcidin is a liver-produced hormone that regulates systemic iron homeostasis. Hepcidin expression is stimulated upon iron overload or inflammation while iron deficiency, anemia and tissue hypoxia are ... -
An Association Study between Hypoxia Inducible Factor-1alpha (HIF-1 alpha) Polymorphisms and Osteonecrosis
Chachami, G.; Kalousi, A.; Papatheodorou, L.; Lyberopoulou, A.; Nasikas, V.; Tanimoto, K.; Simos, G.; Malizos, K. N.; Georgatsou, E. (2013)Bone hypoxia resulting from impaired blood flow is the final pathway for the development of osteonecrosis (ON). The aim of this study was to evaluate if HIF-1 alpha, the major transcription factor triggered by hypoxia, is ... -
Atypical CRM1-dependent nuclear export signal mediates regulation of hypoxia-inducible factor-1 alpha by MAPK
Mylonis, I.; Chachami, G.; Paraskeva, E.; Simos, G. (2008)Hypoxia-inducible factor 1 (HIF-1) is the key transcriptional activator of hypoxia-inducible genes and an important anti-cancer target. Its regulated subunit, HIF-1 alpha, is controlled by oxygen levels and major signaling ... -
Bacterially produced human HIF-1 alpha is competent for heterodimerization and specific DNA-binding
Chachami, G.; Paraskeva, E.; Georgatsou, E.; Bonanou, S.; Simos, G. (2005)Hypoxia-inducible factor 1α (HIF- 1α) is the regulatory Subunit of HIF- 1. the transcriptional activator and key mediator of the cellular response to hypoxia. Regulation of HIF-1α Occurs at multiple levels ... -
Biogenesis of the signal recognition particle (SRP) involves import of SRP proteins into the nucleolus, assembly with the SRP-RNA, and Xpo1p-mediated export
Grosshans, H.; Deinert, K.; Hurt, E.; Simos, G. (2001)The signal recognition particle (SRP) targets nascent secretory proteins to the ER, but how and where the SRP assembles is largely unknown. Here we analyze the biogenesis of yeast SRP, which consists of an RNA molecule ... -
Bortezomib represses HIF-1 alpha protein expression and nuclear accumulation by inhibiting both PI3K/Akt/TOR and MAPK pathways in prostate cancer cells
Befani, C. D.; Vlachostergios, P. J.; Hatzidaki, E.; Patrikidou, A.; Bonanou, S.; Simos, G.; Papandreou, C. N.; Liakos, P. (2012)Bortezomib represents the first proteasome inhibitor (PI) with demonstrated antitumor activity in the clinical setting, particularly for treatment of hematological malignancies. At the preclinical level, its action is shown ... -
Bortezomib represses HIF-1 alpha protein expression and nuclear accumulation by inhibiting both PI3K/Akt/TOR and MAPK pathways in prostate cancer cells (vol 90, pg 45, 2012)
Befani, C. D.; Vlachostergios, P. J.; Hatzidaki, E.; Patrikidou, A.; Bonanou, S.; Simos, G.; Papandreou, C. N.; Liakos, P. (2013) -
Building arks for tRNA: Structure and function of the Arc1p family of non-catalytic tRNA-binding proteins
Karanasios, E.; Simos, G. (2010)Following the intricate architecture of the eukaryotic cell, protein synthesis involves formation of many macromolecular assemblies, some of which are composed by tRNA-aminoacylation enzymes. Protein-protein and protein-tRNA ... -
Casein kinase 1 regulates human hypoxia inducible factor HIF-1
Kalousi, A.; Mylonis, I.; Politou, A. S.; Chachami, G.; Paraskeva, E.; Simos, G. (2010) -
Casein kinase 1 regulates human hypoxia-inducible factor HIF-1
Kalousi, A.; Mylonis, I.; Politou, A. S.; Chachami, G.; Paraskeva, E.; Simos, G. (2010)Hypoxia-inducible factor 1 (HIF-1), a transcriptional activator that mediates cellular response to hypoxia and a promising target of anticancer therapy, is essential for adaptation to low oxygen conditions, embryogenesis ... -
Characterization of the nuclear import pathway for the human hypoxia inducible factor HIF-1alpha
Chachami, G.; Paraskeva, E.; Mingot, J. M.; Gorlich, D.; Simos, G. (2007) -
CK1 delta affects cancer cell adaptation to hypoxia by controlling HIF-1 alpha/ARNT complex formation
Kourti, M.; Mylonis, I.; Giakoumakis, N. N.; Ikonomou, G.; Landegren, U.; Lygerou, Z.; Simos, G. (2014) -
CK1 delta restrains lipin-1 induction, lipid droplet formation and cell proliferation under hypoxia by reducing HIF-1 alpha/ARNT complex formation
Kourti, M.; Ikonomou, G.; Giakoumakis, N. N.; Rapsomaniki, M. A.; Landegren, U.; Siniossoglou, S.; Lygerou, Z.; Simos, G.; Mylonis, I. (2015)Proliferation of cells under hypoxia is facilitated by metabolic adaptation, mediated by the transcriptional activator Hypoxia Inducible Factor-1 (HIF-1). HIF-1 alpha, the inducible subunit of HIF-1 is regulated by oxygen ... -
Cobalt induces hypoxia-inducible factor-1 alpha (HIF-1 alpha) in HeLa cells by an iron-independent, but ROS-, PI-3K- and MAPK-dependent mechanism
Triantafyllou, A.; Liakos, P.; Tsakalof, A.; Georgatsou, E.; Simos, G.; Bonanou, S. (2006)The iron-chelator desferrioxamine (DFO) and the transition metal cobalt induce hypoxia-inducible factor-1 alpha (HIF-1 alpha) in normoxia. DFO stabilizes HIF-1 alpha from proteolysis by inhibiting the activity of iron-dependent ... -
Cobalt induces hypoxia-inducible factor-1 alpha expression in airway smooth muscle cells by a reactive oxygen species- and PI3K-dependent mechanism
Chachami, G.; Simos, G.; Hatziefthimiou, A.; Bonanou, S.; Molyvdas, P. A.; Paraskeva, E. (2004)Cobalt can mimic hypoxia and has been implicated as a cause of lung defects. However, the effect of cobalt on airway smooth muscle (ASM) cells has not been analyzed in detail. In this article, we use primary cultures of ... -
Cobalt inhibits HIF-2-dependent gene expression by blocking HIF-2 alpha/USF2 interaction in liver cancer cells
Befani, C.; Mylonis, I.; Gkotinakou, I. M.; Georgoulias, P. G.; Hu, C. J.; Simos, G.; Liakos, P. (2014) -
Cobalt stimulates HIF-1-dependent but inhibits HIF-2-dependent gene expression in liver cancer cells
Befani, C.; Mylonis, I.; Gkotinakou, I. M.; Georgoulias, P.; Hu, C. J.; Simos, G.; Liakos, P. (2013)Hypoxia-inducible factors (HIFs) are transcriptional regulators that mediate the cellular response to low oxygen. Although HIF-1 is usually considered as the principal mediator of hypoxic adaptation, several tissues and ... -
A complex signaling network involving protein kinase CK2 is required for hepatitis C virus core protein-mediated modulation of the iron-regulatory hepcidin gene expression
Foka, P.; Dimitriadis, A.; Kyratzopoulou, E.; Giannimaras, D. A.; Sarno, S.; Simos, G.; Georgopoulou, U.; Mamalaki, A. (2014)Hepatitis C virus (HCV) infection is associated with hepatic iron overload and elevated serum iron that correlate to poor antiviral responses. Hepcidin (HAMP), a 25-aa cysteine-rich liver-specific peptide, controls iron ... -
The cytoplasmic localization of the tRNA aminoacylation cofactor Arc1p depends on Xpo1p-mediated nuclear export
Galani, K.; Hurt, E.; Simos, G. (2003) -
Detection of new molecular partners of hypoxia inducible factor 1 alpha (HIF-1 alpha)
Lyberopoulou, A.; Gadaras, G.; Venieris, E.; Chachami, G.; Simos, G.; Bonanou, S.; Georgatsou, E. (2005)