Sfoglia per Autore "Bagos, P. G."
Items 21-40 di 40
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HMMpTM: Improving transmembrane protein topology prediction using phosphorylation and glycosylation site prediction
Tsaousis, G. N.; Bagos, P. G.; Hamodrakas, S. J. (2014)During the last two decades a large number of Computational methods have been developed for predicting transmembrane protein topology. Current predictors rely on topogenic signals in the protein sequence, such as the ... -
How Many 3D Structures Do We Need to Train a Predictor?
Bagos, P. G.; Tsaousis, G. N.; Hamodrakas, S. J. (2009)It has been shown that the progress in the determination of membrane protein structure grows exponentially, with approximately the same growth rate as that of the water-soluble proteins. In order to investigate the effect ... -
Impact of HIV Type 1 DNA Levels on Spontaneous Disease Progression: A Meta-Analysis
Tsiara, C. G.; Nikolopoulos, G. K.; Bagos, P. G.; Goujard, C.; Katzenstein, T. L.; Minga, A. K.; Rouzioux, C.; Hatzakis, A. (2012)Several studies have reported the prognostic strength of HIV-1 DNA with variable results however. The aims of the current study were to estimate more accurately the ability of HIV-1 DNA to predict progression of HIV-1 ... -
Key challenges for the creation and maintenance of specialist protein resources
Holliday, G. L.; Bairoch, A.; Bagos, P. G.; Chatonnet, A.; Craik, D. J.; Finn, R. D.; Henrissat, B.; Landsman, D.; Manning, G.; Nagano, N.; O'Donovan, C.; Pruitt, K. D.; Rawlings, N. D.; Saier, M.; Sowdhamini, R.; Spedding, M.; Srinivasan, N.; Vriend, G.; Babbitt, P. C.; Bateman, A. (2015)As the volume of data relating to proteins increases, researchers rely more and more on the analysis of published data, thus increasing the importance of good access to these data that vary from the supplemental material ... -
Meta-Analysis of Family-Based and Case-Control Genetic Association Studies that Use the Same Cases
Bagos, P. G.; Dimou, N. L.; Liakopoulos, T. D.; Nikolopoulos, G. K. (2011)In many cases in genetic epidemiology, the investigators in an effort to control for different sources of confounding and simultaneously to increase the power perform a family-based and a population-based case-control study ... -
Meta-analysis of haplotype-association studies: comparison of methods and empirical evaluation of the literature
Bagos, P. G. (2011)Background: Meta-analysis is a popular methodology in several fields of medical research, including genetic association studies. However, the methods used for meta-analysis of association studies that report haplotypes ... -
A method for meta-analysis of case-control genetic association studies using logistic regression
Bagos, P. G.; Nikolopoulos, G. K. (2007)We propose here a simple and robust approach for meta-analysis of molecular association studies. Making use of the binary structure of the data, and by treating the genotypes as independent variables in a logistic regression, ... -
Methylene tetrahydrofolate reductase gene polymorphisms and their association with methotrexate toxicity: a meta-analysis
Spyridopoulou, K. P.; Dimou, N. L.; Hamodrakas, S. J.; Bagos, P. G. (2012)Objective A systematic review and a meta-analysis were conducted, to investigate the possible association of methylene tetrahydrofolate reductase (MTHFR) gene polymorphisms with adverse effects related to methotrexate ... -
A Multipoint Method for Meta-Analysis of Genetic Association Studies
Bagos, P. G.; Liakopoulos, T. D. (2010)Meta-analyses of genetic association studies are usually performed using a single polymorphism at a time, even though in many cases the individual studies report results from partially overlapping sets of polymorphisms. ... -
On the covariance of two correlated log-odds ratios
Bagos, P. G. (2012)In many applications two correlated estimates of an effect size need to be considered simultaneously to be combined or compared. Apparently, there is a need for calculating their covariance, which however requires access ... -
Percutaneous Coronary Intervention Versus Optimal Medical Therapy for Prevention of Spontaneous Myocardial Infarction in Subjects With Stable Ischemic Heart Disease
Bangalore, S.; Pursnani, S.; Kumar, S.; Bagos, P. G. (2013)Background-Contemporary studies have shown that spontaneous but not procedural myocardial infarction (MI) is related to subsequent mortality. Whether percutaneous coronary intervention (PCI) reduces spontaneous (nonprocedural) ... -
Phoenix 100 versus Vitek 2 in the Identification of Gram-Positive and Gram-Negative Bacteria: a Comprehensive Meta-Analysis
Chatzigeorgiou, K. S.; Sergentanis, T. N.; Tsiodras, S.; Hamodrakas, S. J.; Bagos, P. G. (2011)Phoenix 100 and Vitek 2 (operating with the current colorimetric cards) are commonly used in hospital laboratories for rapid identification of microorganisms. The present meta-analysis aims to evaluate and compare their ... -
Polymorphisms of the CD24 Gene Are Associated with Risk of Multiple Sclerosis: A Meta-Analysis
Braliou, G. G.; Pantavou, K. G.; Kontou, P. I.; Bagos, P. G. (2015)CD24 is a cell-surface protein mainly expressed in cells of the immune and central nervous system (CNS), cells that play a critical role in the development of multiple sclerosis (MS). In the current study, we investigated ... -
Polymorphisms of the insulin receptor and the insulin receptor substrates genes in polycystic ovary syndrome: A Mendelian randomization meta-analysis
Ioannidis, A.; Ikonomi, E.; Dimou, N. L.; Douma, L.; Bagos, P. G. (2010)Polycystic ovary syndrome (PCOS) is a heterogeneous condition with unknown aetiology which is considered to be the most common endocrine disorder in women of reproductive age. In this work we investigated the association ... -
Prediction of cell wall sorting signals in gram-positive bacteria with a hidden markov model: Application to complete genomes
Litou, Z. I.; Bagos, P. G.; Tsirigos, K. D.; Liakopoulos, T. D.; Hamodrakas, S. J. (2008)Surface proteins in Gram-positive bacteria are frequently implicated in virulence. We have focused on a group of extracellular cell wall-attached proteins (CWPs), containing an LPXTG motif for cleavage and covalent coupling ... -
Prediction of Lipoprotein Signal Peptides in Gram-Positive Bacteria with a Hidden Markov Model
Bagos, P. G.; Tslrigos, K. D.; Liakopoulos, T. D.; Hamodrakas, S. J. (2008)We present a Hidden Markov Model method for the prediction of lipoprotein signal peptides of Gram-positive bacteria, trained on a set of 67 experimentally verified lipoproteins. The method outperforms LipoP and the methods ... -
Prediction of signal peptides in archaea
Bagos, P. G.; Tsirigos, K. D.; Plessas, S. K.; Liakopoulos, T. D.; Hamodrakas, S. J. (2009)Computational prediction of signal peptides (SPs) and their cleavage sites is of great importance in computational biology; however, currently there is no available method capable of predicting reliably the SPs of archaea, ... -
The role of genetic polymorphisms of the Renin-Angiotensin System in renal diseases: A meta-analysis
Braliou, G. G.; Grigoriadou, A. M. G.; Kontou, P. I.; Bagos, P. G. (2014)Renal failure has a complex phenotype resulting from an underlying kidney disease as well as environmental and genetic factors. In the present study we performed a systematic review and meta-analyses to evaluate the ... -
Use of Fibrates and Cancer Risk: A Systematic Review and Meta-Analysis of 17 Long-Term Randomized Placebo-Controlled Trials
Bonovas, S.; Nikolopoulos, G. K.; Bagos, P. G. (2012)Background: Fibrates comprise a class of well-established antilipidemic agents that significantly reduce cardiovascular events. Given the concerns of cancer with fibrate therapy, we undertook a systematic review and ... -
Using graph theory to analyze biological networks
Pavlopoulos, G. A.; Secrier, M.; Moschopoulos, C. N.; Soldatos, T. G.; Kossida, S.; Aerts, J.; Schneider, R.; Bagos, P. G. (2011)Understanding complex systems often requires a bottom-up analysis towards a systems biology approach. The need to investigate a system, not only as individual components but as a whole, emerges. This can be done by examining ...