Πλοήγηση ανά Συγγραφέα "Bagos, P. G."
Αποτελέσματα 1-20 από 40
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Apolipoprotein E polymorphisms and type 2 diabetes: A meta-analysis of 30 studies including 5423 cases and 8197 controls
(2010)Type 2 diabetes mellitus (T2DM) is a highly complicated metabolic disorder for which there is worldwide effort for the identification of susceptibility genes. Polymorphisms of the Apolipoprotein E (ApoE) gene are associated ... -
Are Sample Sizes Clear and Justified in RCTs Published in Dental Journals?
(2014)Sample size calculations are advocated by the CONSORT group to justify sample sizes in randomized controlled trials (RCTs). The aim of this study was primarily to evaluate the reporting of sample size calculations, to ... -
The association between apolipoprotein E gene polymorphisms and essential hypertension: a meta-analysis of 45 studies including 13 940 cases and 16 364 controls
(2013)The apolipoprotein E single-nucleotide polymorphisms are among the potential candidate genes that may serve as modulators in susceptibility to essential hypertension. In an effort to clarify earlier inconclusive results, ... -
The association between plasminogen activator inhibitor type 1 (PAI-1) levels, PAI-1 4G/5G polymorphism, and myocardial infarction: a Mendelian randomization meta-analysis
(2014)Background: The circulating levels of plasminogen activator inhibitor type 1 (PAI-1) are increased in individuals carrying the 4G allele at position -675 of the PAI-1 gene. In turn, overexpression of PAI-1 has been found ... -
Bacterial β-barrel outer membrane proteins: A common structural theme implicated in a wide variety of functional roles
(2008)β-barrel outer membrane proteins constitute the second and less well-studied class of transmembrane proteins. They are present exclusively in the outer membrane of Gram-negative bacteria and presumably in the outer membrane ... -
Combined prediction of Tat and Sec signal peptides with hidden Markov models
(2010)Motivation: Computational prediction of signal peptides is of great importance in computational biology. In addition to the general secretory pathway ( Sec), Bacteria, Archaea and chloroplasts possess another major pathway ... -
Computational methods for the prediction of GPCRs coupling selectivity
(2008)GPCRs comprise a wide and diverse class of eukaryotic transmembrane proteins with well-established pharmacological significance. As a consequence of recent genome projects, there is a wealth of information at the sequence ... -
Creating a specialist protein resource network: a meeting report for the protein bioinformatics and community resources retreat
(2015)During 11-12 August 2014, a Protein Bioinformatics and Community Resources Retreat was held at the Wellcome Trust Genome Campus in Hinxton, UK. This meeting brought together the principal investigators of several specialized ... -
CW-PRED: A HMM-based method for the classification of cell wall-anchored proteins of Gram-positive bacteria
(2012)Gram-positive bacteria have surface proteins that are often implicated in virulence. A group of extracellular proteins attached to the cell wall contains an LPXTG-like motif that is target for cleavage and covalent coupling ... -
Cytokine gene polymorphisms in multiple sclerosis: a meta-analysis of 45 studies including 7379 cases and 8131 controls
(2011)Many environmental and genetic factors have been implicated in the development of multiple sclerosis. However, the aetiology has not been clarified yet. Therefore, using a meta-analytic approach, we tried to probe the ... -
Cytokine gene polymorphisms in periodontal disease: a meta-analysis of 53 studies including 4178 cases and 4590 controls
(2008)Aim: We conducted a systematic review and a meta-analysis, in order to investigate the potential association of cytokine gene polymorphisms with either aggressive or chronic periodontal disease. Material and Methods: A ... -
Developing the Evidence Base for Cancer Chemoprevention: Use of Meta-Analysis
(2011)Meta-analysis is a quantitative approach for systematically combining the results of previous studies in order to arrive at conclusions about the body of research. It answers a specific research question, includes an ... -
Effect of hepatitis C virus on immunological and virological responses in HIV-infected patients initiating highly active antiretroviral therapy: a meta-analysis
(2013)Co-infection of human immunodeficiency virus (HIV) with hepatitis C virus (HCV) is rather common. In the era of highly active antiretroviral therapy (HAART), viral hepatitis could result in adverse outcomes in HIV+ patients. ... -
Emerging molecular networks common in ionizing radiation, immune and inflammatory responses by employing bioinformatics approaches
(2015)Efficient radiation therapy is characterized by enhanced tumor cell killing involving the activation of the immune system (tumor immunogenicity) but at the same time minimizing chronic inflammation and radiation adverse ... -
ExTopoDB: a database of experimentally derived topological models of transmembrane proteins
(2010)ExTopoDB is a publicly accessible database of experimentally derived topological models of transmembrane proteins. It contains information collected from studies in the literature that report the use of biochemical methods ... -
Fc gamma receptor polymorphisms and their association with periodontal disease: a meta-analysis
(2010)Aim: A systematic review and a meta-analysis were conducted in order to investigate the potential association of Fc gamma receptor (Fc gamma R) polymorphisms with susceptibility to aggressive and chronic periodontal disease. ... -
Generalized least squares for assessing trends in cumulative meta-analysis with applications in genetic epidemiology
(2009)Objective: Cumulative meta-analysis allows the evaluation of a study's contribution to the combined effect of the preceding research. It accrues evidence, gradually adding studies one at a time and provides updated estimates ... -
Genetic model selection in genome-wide association studies: robust methods and the use of meta-analysis
(2013)In genetic association studies (GAS) as well as in genome-wide association studies (GWAS), the mode of inheritance (dominant, additive and recessive) is usually not known a priori. Assuming an incorrect mode of inheritance ... -
GPCRs, G-proteins, effectors and their interactions: human-gpDB, a database employing visualization tools and data integration techniques
(2010)G-protein coupled receptors (GPCRs) are a major family of membrane receptors in eukaryotic cells. They play a crucial role in the communication of a cell with the environment. Ligands bind to GPCRs on the outside of the ... -
gpDB: a database of GPCRs, G-proteins, effectors and their interactions
(2008)gpDB is a publicly accessible, relational database, containing information about G-proteins, G-protein coupled receptors (GPCRs) and effectors, as well as information concerning known interactions between these molecules. ...