Πλοήγηση ανά Συγγραφέα "Pitsikas, N."
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Memantine and recognition memory: Possible facilitation of its behavioral effects by the nitric oxide (NO) donor molsidomine
Pitsikas, N.; Sakellaridis, N. (2007)The effects of the non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist memantine on recognition memory were investigated in the rat by using the object recognition task. In addition, a possible interaction ... -
The metabotropic glutamate 2/3 receptor agonist LY379268 counteracted ketamine-and apomorphine-induced performance deficits in the object recognition task, but not object location task, in rats
Pitsikas, N.; Markou, A. (2014)Experimental evidence indicates that the non competitive N-methyl-D-aspartate (NMDA) receptor antagonist ketamine and the mixed dopamine (DA) D-1/D-2 receptor agonist apomorphine induce schizophrenia-like symptoms in ... -
The metabotropic glutamate 2/3 receptor agonist LY379268 induces anxiety-like behavior at the highest dose tested in two rat models of anxiety
Grivas, V.; Markou, A.; Pitsikas, N. (2013)The activation of Group If metabotropic glutamate 2/3 (mGlu(2/3)) receptors reduces the excessive glutamate release that is hypothesized to be associated with neurodegenerative and psychiatric disorders. LY379268 is a ... -
The metabotropic glutamate 2/3 receptor antagonist LY341495 differentially affects recognition memory in rats
Pitsikas, N.; Kaffe, E.; Markou, A. (2012)Experimental evidence suggests that metabotropic glutamate 2/3 (mGlu2/3) receptor antagonists affect cognitive function, although contradictory findings have been reported. To clarify the role of mGlu2/3 receptor antagonists ... -
The metabotropic glutamate receptors: Potential drug targets for the treatment of anxiety disorders?
Pitsikas, N. (2014)Anxiety-related disorders are a common public health issue. Several lines of evidence suggest that altered glutamatergic neurotransmission underlies anxiety. Thus, novel molecules targeting glutamatergic neurotransmission, ... -
Molsidomine antagonizes L-NAME-induced acquisition deficits in a recognition memory task in the rat
Pitsikas, N.; Rigamonti, A. E.; Bonomo, S. M.; Cella, S. G.; Muller, E. E. (2003)The present study was designed to investigate the role of nitric oxide (NO) on the acquisition of a recognition memory, task in the rat. For this purpose, the effects on memory exerted by pre-training administration of the ... -
The nitric oxide (NO) donor molsidomine antagonizes scopolamine and L-NAME-induced performance deficits in a spatial memory task in the rat
Pitsikas, N. (2009)Nitric oxide (NO) is considered as an intracellular messenger in the brain. Its involvement in learning and memory processes has been proposed. Compounds that inhibit NO synthase (NOS), the key synthesizing enzyme, may ... -
The Nitric Oxide Donor Molsidomine Antagonizes Age-Related Memory Deficits in the Rat
Pitsikas, N.; Rigamonti, A. E.; Muller, E. E. (2004) -
The nitric oxide donor molsidomine antagonizes age-related memory deficits in the rat
Pitsikas, N.; Rigamonti, A. E.; Cella, S. G.; Sakellaridis, N.; Muller, E. E. (2005)The effects of the nitric oxide (NO) donor molsidomine on aged rats' cognition were evaluated in two different behavioral tasks: the step-through passive avoidance paradigm and the object recognition test. Post-training ... -
Nitric oxide donor molsidomine attenuates psychotomimetic effects of the NMDA receptor antagonist MK-801
Pitsikas, N.; Zisopoulou, S.; Sakellaridis, N. (2006)There is experimental evidence indicating that the noncompetitive NMDA receptor antagonist MK-801 impairs cognition and produces a series of schizophrenia-like symptoms in rodents (hypermotility, stereotypies, and ataxia). ... -
Nitric oxide modulates apomorphine-induced recognition memory deficits in rats
Gourgiotis, I.; Kampouri, N. G.; Koulouri, V.; Lempesis, I. G.; Prasinou, M. D.; Georgiadou, G.; Pitsikas, N. (2012)Nitric oxide (NO) is an important intracellular messenger in the brain. The implication of NO in schizophrenia is well documented although it is not yet clear whether net over or underproduction of NO is typical of this ... -
The nitric oxide-releasing derivative of ferulic acid NCX 2057 antagonized delay-dependent and scopolamine-induced performance deficits in a recognition memory task in the rat
Boultadakis, A.; Liakos, P.; Pitsikas, N. (2010)Nitric oxide (NO) is considered as an intracellular messenger in the brain. its involvement in learning and memory processes has been proposed. The present study was designed to investigate the effects of the NO-releasing ... -
PKC-epsilon activation is required for recognition memory in the rat
Zisopoulou, S.; Asimaki, O.; Leondaritis, G.; Vasilaki, A.; Sakellaridis, N.; Pitsikas, N.; Mangoura, D. (2013)Activation of PKC epsilon, an abundant and developmentally regulated PKC isoform in the brain, has been implicated in memory throughout life and across species. Yet, direct evidence for a mechanistic role for PKC epsilon ... -
Pre-training administration of anesthetic ketamine differentially affects rats' spatial and non-spatial recognition memory
Pitsikas, N.; Boultadakis, A. (2009)There is poor experimental evidence concerning the effects of anesthetic doses of the non-competitive NMDA receptor antagonist ketamine on rodents' memory abilities. The present study was designed to investigate a) the ... -
Repeated administration of the nitric oxide synthase inhibitor L-NAME differentially affects rats' recognition memory
Georgiadou, G.; Pitsikas, N. (2011)Nitric oxide (NO) is sought to be an intracellular messenger in the central nervous system and its implication in learning and memory is well documented. Compounds that inhibit nitric oxide synthase (NOS), the key synthesizing ... -
The role of nitric oxide in the object recognition memory
Pitsikas, N. (2015)The novel object recognition task (NORT) assesses recognition memory in animals. It is a non-rewarded paradigm that it is based on spontaneous exploratory behavior in rodents. This procedure is widely used for testing the ... -
The selective 5-HT6 receptor antagonist Ro 04-6790 attenuates psychotomimetic effects of the NMDA receptor antagonist MK-801
Pitsikas, N.; Zisopouiou, S.; Pappas, I.; Sakellaridis, N. (2008)There are experimental evidences indicating that the non-competitive NMDA receptor antagonist MK-801 impairs cognition and produces a series of schizophrenia-like symptoms in rodents (hypermotility, stereotypies and ataxia). ... -
WIN55,212-2 impairs non-associative recognition and spatial memory in rats via CB1 receptor stimulation
Galanopoulos, A.; Polissidis, A.; Georgiadou, G.; Papadopoulou-Daifoti, Z.; Nomikos, G. G.; Pitsikas, N.; Antoniou, K. (2014)Endogenous and exogenous cannabinoids modulate learning and memory primarily via the cannabinoid type 1 receptor (CB1R). A variety of experimental procedures has focused on the role of CB1R in various aspects of learning ...