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Biomarkers in prostate-specific membrane antigen theranostics

dc.creatorVlachostergios P.J., Zachos I., Tzortzis V.en
dc.date.accessioned2023-01-31T11:36:58Z
dc.date.available2023-01-31T11:36:58Z
dc.date.issued2021
dc.identifier10.3390/diagnostics11061108
dc.identifier.issn20754418
dc.identifier.urihttp://hdl.handle.net/11615/80662
dc.description.abstractTheranostics of prostate cancer (PC) represents a growing area of development of imaging agents and targeted radionuclide therapeutics against a major target, prostate specific membrane antigen (PSMA). In view of the encouraging efficacy from the use of177 Lu and other radionuclides in metastatic castration-resistant prostate cancer (mCRPC), it is becoming increasingly important to identify surrogate markers that can help predict which patients are more likely to respond and experience improved survival. This review discusses potential predictors of efficacy of PSMA-targeted radionuclide therapies (TRT) segregated in three major categories: imaging, clinical and molecular. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.en
dc.language.isoenen
dc.sourceDiagnosticsen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85109087682&doi=10.3390%2fdiagnostics11061108&partnerID=40&md5=4d44602a241e6c7aa79e418480f62084
dc.subjectalkaline phosphataseen
dc.subjectanalgesic agenten
dc.subjectbiological markeren
dc.subjectchromogranin Aen
dc.subjectfluorodeoxyglucose f 18en
dc.subjecthemoglobinen
dc.subjectlactate dehydrogenaseen
dc.subjectlutetium 177en
dc.subjectneuroendocrine specific proteinen
dc.subjectneurotensin receptoren
dc.subjectprostate specific antigenen
dc.subjectprostate specific membrane antigenen
dc.subjectalkaline phosphatase blood levelen
dc.subjectcancer prognosisen
dc.subjectcancer survivalen
dc.subjectcancer tissueen
dc.subjectcirculating tumor cellen
dc.subjectcomposite predictive scoreen
dc.subjectDNA damage responseen
dc.subjectDNA repairen
dc.subjectdrug efficacyen
dc.subjectdrug therapyen
dc.subjectGleason scoreen
dc.subjecthumanen
dc.subjectlactate dehydrogenase blood levelen
dc.subjectmetastasisen
dc.subjectmetastatic castration resistant prostate canceren
dc.subjectmutationen
dc.subjectoverall survivalen
dc.subjectpainen
dc.subjectplatelet counten
dc.subjectpositron emission tomographyen
dc.subjectprogression free survivalen
dc.subjectprotein expressionen
dc.subjectradioisotope therapyen
dc.subjectReviewen
dc.subjectscoring systemen
dc.subjectstandardized uptake valueen
dc.subjecttheranostic nanomedicineen
dc.subjecttreatment responseen
dc.subjecttumor doubling timeen
dc.subjecttumor volumeen
dc.subjectMDPIen
dc.titleBiomarkers in prostate-specific membrane antigen theranosticsen
dc.typeotheren


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