A Real-World, Multicenter, 6-Month Prospective Study in Greece of the Effectiveness and Safety of Ranibizumab in Patients with Age-Related Macular Degeneration Who Have Inadequately Responded to Aflibercept: The “ELEVATE” Study
Data
2022Language
en
Soggetto
Abstract
Purpose: Real-world evidence on short-term outcomes of ranibizumab in wet age-related macular degeneration (wAMD) following inadequate response to aflibercept is scarce. This study aimed to evaluate the functional and anatomic effects of switching to ranibizumab in cases of wAMD previously treated with aflibercept with inadequate response. Patients and Methods: Prospective, observational study performed in eight ophthalmology hospital/private clinics in Greece, enrolling consented patients with active wAMD, ≥50 years-old, who had initiated ranibizumab ≥28 days and <2 months after their last aflibercept injection. Data were collected at enrollment, and at 1, 3 and 6 months post-treatment onset (post-baseline). Results: Between September-2015 and November-2017, 103 eligible patients (56.3% females; mean age: 74.8±8.6 years) were consecutively enrolled. The age at AMD diagnosis in the study eye was 71.3±8.8 years. Aflibercept (median of 5 injections received over 11.3 months) had been discontinued for anatomical (in 69.9%) and/or functional (38.8%) reasons. At baseline (median: 24.3 months after wAMD diagnosis), choroidal neovascularization was occult in 69.1% of evaluable study eyes; 60.2% of the study eyes had pigment epithelial detachment (PED); 42.7% cysts; 21.4% fibrosis; 66.0% subretinal, and 59.2% intraretinal fluid. At 6 months post-baseline: a median of 3 ranibizumab injections (range: 1–6) had been received; the best-corrected visual acuity (BCVA)≥0 letter gain rate was 81.8%; the BCVA ≥15 letter gain rate was 17.0%; BCVA gain was 3.2 letters [mean increase: 3.2±10.0 letters; median: 0.0; p = 0.002]; PED greatest basal diameter (GBD; median: 1470.5 μm) also decreased (median decrease: 114.0 μm; p = 0.019). Baseline central retinal thickness (CRT; median: 312.0 μm) remained unchanged. One patient permanently discontinued ranibizumab due to adverse event occurrence, assessed as not causally related to ranibizumab. There were no ranibizumab-related adverse reactions. Conclusion: Six-month treatment with ranibizumab in aflibercept inadequate responders led to visual acuity and PED GBD improvements, with no statistically significant CRT change. © 2022 Rouvas et al.
Collections
Related items
Showing items related by title, author, creator and subject.
-
EPIdemiology of Surgery-Associated Acute Kidney Injury (EPIS-AKI): Study protocol for a multicentre, observational trial
Weiss R., Saadat-Gilani K., Kerschke L., Wempe C., Meersch M., Zarbock A., Makhloufi H., Cherak A., Ghanem L.L., Gouaglia Z., Guadouri D.N., Hama F.N., Kara M., Saadi O., Sakhraoui R., Bourou F., Cherifi A., Sadaoui R.G., Ouyahia A., Ouahab I., Bouaoud S., Abdoun M., Tidjane A., Tabeti B., Boudjenan-Serradj N., Rivera C.J.P., Cabrer P., Corso J., García J.P., Idarraga S., Montoya C., Figueroa R., Aldana E., Torrado M.A., Peng K., Ma Z.-M., Yang Y.-F., Zhu Y.-J., Sklienka P., Frelich M., Jarkulis V., Sevcik P., Vodicka V., Elbahnasawy M.G., Elsalhawy S., Motawea S., Othman Z., Sahma M., Nafea A.M., Ahmed N., Attia D.A., Emara M.M., Bonna M.M., Gabr M.A., Tarbay A.I., Abdehaleem I.A., Mohamed E.E., Eldeeb A.M., Abbas A.M., Magdy J.A., Hamed Z.H., Osman H.M.E., Abbas M.S., Joannes-Boyau O., Barraud N., Berthelot C., Camus T., Dahmi A., Defaye M., Derville S., El-Boustani Y., Deloge E., Jacob H., Monziols S., Priem F., Robin J.-J., Legros V., Floch T., Muccio S., Geneve C., Legouge M.L., Mauny S.T., Mfam W., Pascot L., Aveline C., Chartier M., Duteurtre B., Gautier J.F., Cousin A.L., Vautier P., Nadaud J., Begel N., Chekirine C.-A., Derlon V., Grein E., Lehair M.-A., Magazzeni L., Magazzeni P., Potter C., Roth C., Voivret F., Rimmelé T., Cerro V., Suria S., Elmawieh J., Stoclin A., Cirenei C., Andrieu G., Couloumy S., Falcone J., Fajardy M., Gagneuil A., Girardet E., Mazereeuw A., Ponsonnard S., Egreteau P.-Y., Bertel M., Bocher S., Carn V., Guen L.L., Loup G.L., Lefevre M., Ichai C., Diop A., Jean-Michel V., Devlieger S., Duthoit J., El Kadiri M., Léger M., Cassisa V., Lasocki S., Masson C., Rineau E., Verrier P., Coquerel A., Montravers P., Atchade E., Rochon C.-E., Delerue C., Quentin V., Latry V., Queixalos N., Cottenceau V., Braun T., Bouzoubaa S., Christ B., Geiger A., Gomille J., Kieffer V., Mangeant S., Prochilo C., Schmitt C., Skwirba S., Grand H., Boury F., Mayeur N., Pasquie M., Garçon P., Bruckert V., Arnould V., Bonciu M., Chapelle T., Facchino L., Fagot-Gandet F., Iachim A., Mannu E., Perus O., Plattier R., Rozier R., Pradel G., Boudinaud M., Hausermann M.-H., Nguyen M.H., Ramorasata A., Barreau A., Boivin A.-H., Ravry C., Mottard N., Beuvelot J., Bossion F.P., Desebbe O., Zarbock A., Dörr C., von Groote T.C., Küllmar M., Massoth C., Meersch M., Saadat-Gilani K., Weiss R., Wempe C., Ziemann S., Grüßer L., Kowark A., Wittig P., Brandenburger T., Dimski T., Döhmen N., Huthmann L., Kaierle D., Pelletier C., Schleß M., Hohn A., Cleophas S., Haunhorst S., Jansen M., Schmitt A., Soisch J., Sturm K., Rosenberger P., Bendig A., Flohr L., Häberle H., Hofmann P., Kuhle J., Leser N.M., Pfister K., Prohaska S., Sennholz F., Stetz L., Weber K., Stehr S., Klaus S., Sadlo M., Boschin M., Sengelhoff C., Göbel U.M., Haaker J.G., Göttker C.-K., Gründel M., Heringlake M., Baumgärtel R., Berggren A., Gülzow M., Muras L., Paarmann H., Thal S., Bentley A., El-Masri D., Sebastiani A., Arnaoutoglou E., Ntalouka M., Stratigopoulou P., Analytis A., Mavrommatis E., Tzimas P., Karakosta A., Pantazi D., Dimakopoulou A., Dimitropoulou K., Ioannidis O., Jalaawiy H., Anwar A., Hashim H.T., Aldawoody H.I.R., Cortegiani A., Catalisano G., Ingoglia G., Ippolito M., De Rosa S., Cattin L., Bianchin A., Barone M., Paternoster G., Cutuli S.L., Russo A., Sollazzi L., Cascarano L., Antonelli M., Aceto P., Romanò B., Spadaro S., Tripodi V.F., Rossi M., Scappatura R., Vadalà M.C., Fiume D., Strano M.T., Oddo G., Santorsola C., Hussain B.A., Alnaser A.R., Ghassan A.H., Hasanein K., Theab M., Shin S., Jung S., Lee K., Jung S.M., Baek J., Elhadi M.K., Aldressi W.W.O., Abuzeid I., Albaraesi M., Aldressi S., Khalel W., Abdulwahed E., Abujrad A.A.A., Almaghrabi A., Alteleeb M., Alshareea E.A.A., Biala M.I., Deeknah A., Gheddim D.A., Ghmagh R., Ikhrays N.S.A.A., Sinan M., Soula E., Bahroun S.G., Derwish K., Mohamed A.M., Younes E.S., Al Islam Benjouira R., Aliwa M., Altashani N.A., Alteb M.O., Msherghi A., Alagelli F., Albarouni S., Albishti A., Aljamal S., Alsori M., Ekhuja T., Elzwai S., Ghula M., Mustafa T., Tuwaib A., Zriba H., Agilla H.M., Rafanomezantsoa T.A., Podesta A.M.C., Bonnici D.M., Pirotta T., López G.A.G., Mijovska M.M., Davitkovska T., Gavrilovska A., Lukikj S., Vesova M., Zafirova D., Amro S., Hajjaj B.N.F., Alkhazendar M., Barakat Y., Elejla S.A., Elhissi A., Khader A., Salem A., de Freitas Regufe R., de Oliveira Eloy A.F., Perdigão L.M.N.C., Grigoriev E., Ivkin A., Kornelyuk R., Yaroustovsky M., Abramyan M., Komardina E., Lesteva N., Aybazova M., Kumykova E., Lesina S., Rybakov G., Shestov A., Barmou A.A.A., Ahmed B.L.A., Eliyas A.M., Emadeldin Y., Kaserer A., Castellucci C., Rössler J., Akbas S., Petrun A.M., Gregorcic I., Sok V., Cicak R., Bárcena E., Guisado A., Wi I., Melchor J.R., Becerra-Bolaños Á., Cabrera-Doreste S., Domínguez-Arbelo A., Delgado-Alonso M.C., Muiño-Palomar V., Rodríguez-Pérez A., Estévez J.M., Munoz M.B.C., Matas J.M., Palao S.P., Quirós M.D.M., Teslev A.C., Argilaga M., Campos M., Bainac A., Batalla A., Alvarez M.G., Giné M., Herránz G., Hinojal I., Ejea M.L., de la Rosa Ruiz N., Abasolo M.G., Acuna C.R.H., Zaranton I.I., Mendigurenmurua A., Sanz M.J.M., de la Fuente E.O., Vaquero M.P.P., Iglesias A.S., Mieres A.U., Urrestizala A.U., Ferreira L., Lobato F., Sevilla M.A., Erazo A., Miró P., Sabaté S., Vernetta D., Perez A.A., Pagola M.A., Paulis B.C., del Val Peciña E., Odriozola A.G., Aizpurua A.L., Piquer O.P., Garcia P.P., Rezola P.O., Lopez A.O., de la Calle Gil I., Casado R.N., Adamove P., Domenge R.B., Blasco F.M.B., Villamizar A.A.R., Llaneras M.A.P., García-Sánchez J.I., Téllez L.F., Zamorano S.G., Herreros N.G., Esteve A.R., Rodríguez P.M., Trigo I.G., Alcaraz A., Jiménez A.L., Rubio I., García N., Callejas R., Toha A.M.C., Claros E., Cobeta P., Crespo P., Dorado T., Elías E., Felices J., Gil D., Gómez M., Mané N., Martín M., Martínez A., Pereira L., Samaranch A.B.N., Serrano A., Tiscar C., VillaHoz J., Menéndez P.G., Cardona E., Conesa A., Estepa V., Galán P., Espí L.L., Aldeán Y.L., Manrique S., Ariza V.M., Villa L.V., Suliman E.S.M.A., Hamid H., Ibrahim A.M., Saeed M.M., Mukadder O.S., Altun D., Canbolat N., Dinçer M.B., Seyhan T.Ö., Yildirim S.A., Iyigün M., Yapici D., Özdemir L., Sagun A., Boztug N., Cetintas Y., Dinc B., Gündüz E., Ünlügenç H., Tunay D.L., Karakaya D., Dost B., Komurcu O., Akcil E.F., Dilmen Ö.K., Tunali Y., Ok G., Alsina E.T., Hakli Ö., Polat C., Turgut N., Kizilcik N., Köner Ö., Sen Ö., Aydin N., Basaran B., Bingul E.S., Gürkan Y., Darcin K., Ugur S., Saracoglu K.T., Demir A., Aysegül Ö., Balci E., Girgin B., Guler A., Karadeniz Ü., Özaslan N., Hülya Y.Ö., Ozcan N., Postaci A., Sahap M., Salman N., Sagir Ö., Atik B., Bicakcioglu M., Demir H.F., Fatih U., Kocaoglu N., Toprak H.I., Aslan D.D., Colak Y.Z., Ozcan M.S., Yilmaz M., Karaca U., Sahin S.H., Karka Ö.E., Senoglu G.D., Karadag S.E., Alkis N., Baytas V., Akdogan A., Besir A., Erturk E., Kutanis D., Saylan S., Tugcugil E., Ayvat P., Günaydin B., Büyükgebiz B.M., Boran O.F., Calisir F., Orak Y., Balkan B.K., Büyükcoban S., Gökel E., Günenc S.F., Özbilgin S., Göre S., Akesen S., Cansabuncu S., Momot N., Panchenko A., Pittet J.-F., Rutledge K., the EPIS-AKI Investigators (2021)Introduction More than 300 million surgical procedures are performed each year. Acute kidney injury (AKI) is a common complication after major surgery and is associated with adverse short-term and long-term outcomes. ... -
Direct oral anticoagulant-vs Vitamin K antagonist-related nontraumatic intracerebral hemorrhage
Tsivgoulis G., Lioutas V.-A., Varelas P., Katsanos A.H., Goyal N., Mikulik R., Barlinn K., Krogias C., Sharma V.K., Vadikolias K., Dardiotis E., Karapanayiotides T., Pappa A., Zompola C., Triantafyllou S., Kargiotis O., Ioakeimidis M., Giannopoulos S., Kerro A., Tsantes A., Mehta C., Jones M., Schroeder C., Norton C., Bonakis A., Chang J., Alexandrov A.W., Mitsias P., Alexandrov A.V. (2017)Objective: To compare the neuroimaging profile and clinical outcomes among patients with intracerebral hemorrhage (ICH) related to use of vitamin K antagonists (VKAs) or direct oral anticoagulants (DOACs) for nonvalvular ... -
Malignant mesothelioma cells secrete natriuretic peptides: Data and diagnostic clinical implications
Tsolaki V., Zarogiannis S., Zygoulis P., Kalomenidis I., Jagirdar R., Makris D., Daniil Z., Magkouta S., Triantafyllou I., Papanikolaou J., Gourgoulianis K.I., Zakynthinos E. (2020)Background and objective: Mesothelial cells and cardiomyocytes have shared embryonic mesodermal origin. Cardiomyocytes release BNP under stretch. We searched whether malignant mesothelioma cells also secrete BNP and if so, ...