dc.creator | Rigopoulos A.G., Klutt B., Matiakis M., Apostolou A., Mavrogeni S., Noutsias M. | en |
dc.date.accessioned | 2023-01-31T09:51:28Z | |
dc.date.available | 2023-01-31T09:51:28Z | |
dc.date.issued | 2019 | |
dc.identifier | 10.3390/v11060566 | |
dc.identifier.issn | 19994915 | |
dc.identifier.uri | http://hdl.handle.net/11615/78504 | |
dc.description.abstract | Background: Diverse viral infections have been associated with myocarditis (MC) and dilated cardiomyopathy (DCM). In this meta-analysis, we summarize the published results on the association of parvovirus B19 (B19V) genomes with human MC/DCM versus controls. Methods: N = 197 publications referring to B19V and MC or DCM were retrieved using multiple PubMed search modes. Out of these, n = 29 publications met the inclusion criteria with data from prospective analyses on >10 unselected patients presenting with MC or DCM (dataset: MA01). Data retrieved simultaneously from both controls and MC/DCM patients were available from n = 8 from these publications (dataset: MA02). Results: In the dataset MA01 B19V genomes were detected in 42.6% of the endomyocardial biopsies (EMB) in this cohort by PCR. In the dataset MA02 comprising n = 638 subjects, there was no statistically significant different rate of B19V positivity in myocardial tissues comparing controls(mean: 38.8 + 24.1%) versus the MC/DCM-patients(45.5 + 24.3%;p = 0.58). There was also no statistical difference between the positivity rate of B19V genomes in myocardial tissues of MA01 (46.0 + 19.5%) and the two patient groups of MA02 (p > 0.05). Conclusions: This systematic review reveals that the mean rate of PCR detected B19V genomes in patients presenting with MC/DCM does not differ significantly from the findings in control myocardial tissues. These data imply pathogenetically insignificant latency of B19V genomes in a proportion of myocardial tissues, both in MC-/DCM-patients and in controls. More information (i.e., replicative status, viral protein expression) is pertinent to achieve a comprehensive workup of myocardial B19V infection. © 2019 by the authors. Licensee MDPI, Basel, Switzerland. | en |
dc.language.iso | en | en |
dc.source | Viruses | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85068490628&doi=10.3390%2fv11060566&partnerID=40&md5=01a8e898116c763aca638b9505745bf6 | |
dc.subject | immunoglobulin A | en |
dc.subject | viral protein | en |
dc.subject | Adenoviridae | en |
dc.subject | congestive cardiomyopathy | en |
dc.subject | Cytomegalovirus | en |
dc.subject | data extraction | en |
dc.subject | Enterovirus | en |
dc.subject | Epstein Barr virus | en |
dc.subject | erythema infectiosum | en |
dc.subject | genome | en |
dc.subject | genome analysis | en |
dc.subject | heart left ventricle ejection fraction | en |
dc.subject | heart left ventricle enddiastolic diameter | en |
dc.subject | heart muscle biopsy | en |
dc.subject | human | en |
dc.subject | Human herpesvirus 6 | en |
dc.subject | Human parvovirus B19 | en |
dc.subject | meta analysis | en |
dc.subject | myocarditis | en |
dc.subject | polymerase chain reaction | en |
dc.subject | prospective study | en |
dc.subject | protein expression | en |
dc.subject | Review | en |
dc.subject | systematic review | en |
dc.subject | virus genome | en |
dc.subject | virus load | en |
dc.subject | biopsy | en |
dc.subject | classification | en |
dc.subject | congestive cardiomyopathy | en |
dc.subject | genetics | en |
dc.subject | Human parvovirus B19 | en |
dc.subject | isolation and purification | en |
dc.subject | myocarditis | en |
dc.subject | parvovirus infection | en |
dc.subject | polymerase chain reaction | en |
dc.subject | virology | en |
dc.subject | Biopsy | en |
dc.subject | Cardiomyopathy, Dilated | en |
dc.subject | Humans | en |
dc.subject | Myocarditis | en |
dc.subject | Parvoviridae Infections | en |
dc.subject | Parvovirus B19, Human | en |
dc.subject | Polymerase Chain Reaction | en |
dc.subject | MDPI AG | en |
dc.title | Systematic review of pcr proof of parvovirus b19 genomes in endomyocardial biopsies of patients presenting with myocarditis or dilated cardiomyopathy | en |
dc.type | other | en |