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On the immunoregulatory role of statins in multiple sclerosis: the effects on Th17 cells

dc.creatorNtolkeras G., Barba C., Mavropoulos A., Vasileiadis G.K., Dardiotis E., Sakkas L.I., Hadjigeorgiou G., Bogdanos D.P.en
dc.date.accessioned2023-01-31T09:40:55Z
dc.date.available2023-01-31T09:40:55Z
dc.date.issued2019
dc.identifier10.1007/s12026-019-09089-5
dc.identifier.issn0257277X
dc.identifier.urihttp://hdl.handle.net/11615/77356
dc.description.abstractStatins, the cholesterol-lowering drugs, also possess immunomodulatory properties, affecting among others T cell activation and differentiation, antigen presentation, and regulatory T cell (Tregs) maintenance and differentiation. Their effects on autoagression have led investigators to assess their clinical significance in autoimmune disease, such as multiple sclerosis (MS), a chronic progressive demyelinating disease of autoimmune nature. The dysregulated immunity noted in MS features a profound shift from Tregs dominance to Th17 cell superiority. In this review, we discuss the immunobiological basis of statins, their role in autoimmunity related to MS, and the data from experimental models and human studies on their effect on Th17 cells. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.en
dc.language.isoenen
dc.sourceImmunologic Researchen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85070384619&doi=10.1007%2fs12026-019-09089-5&partnerID=40&md5=5f5564b2ddf4451cb4f49115654bef23
dc.subjectalpha2 integrinen
dc.subjectatorvastatinen
dc.subjectbeta interferonen
dc.subjectCD39 antigenen
dc.subjectcerivastatinen
dc.subjectcytotoxic T lymphocyte antigen 4en
dc.subjectezetimibeen
dc.subjectfluindostatinen
dc.subjectgelatinase Aen
dc.subjectgelatinase Ben
dc.subjecthepatitis A virus cellular receptor 2en
dc.subjectinterleukin 10en
dc.subjectinterleukin 17en
dc.subjectinterleukin 2 receptor alphaen
dc.subjectinterleukin 21en
dc.subjectinterleukin 23en
dc.subjectinterleukin 35en
dc.subjectinterleukin 6en
dc.subjectlymphocyte activation protein 3en
dc.subjectlymphocyte receptoren
dc.subjectmevinolinen
dc.subjectprogrammed death 1 receptoren
dc.subjectrosuvastatinen
dc.subjectsimvastatinen
dc.subjectSmad2 proteinen
dc.subjectSmad3 proteinen
dc.subjectSTAT5 proteinen
dc.subjecttranscription factor FOXP3en
dc.subjecttransforming growth factor betaen
dc.subjectunclassified drugen
dc.subjectunindexed drugen
dc.subjecthydroxymethylglutaryl coenzyme A reductase inhibitoren
dc.subjectimmunologic factoren
dc.subjectapoptosisen
dc.subjectCD4+ CD25+ T lymphocyteen
dc.subjectCD8+ T lymphocyteen
dc.subjectcell migrationen
dc.subjectcytokine productionen
dc.subjectcytokine releaseen
dc.subjectdown regulationen
dc.subjectenzyme inhibitionen
dc.subjecthumanen
dc.subjectimmunobiologyen
dc.subjectimmunoregulationen
dc.subjectin vitro studyen
dc.subjectlymphocyte differentiationen
dc.subjectlymphocyte proliferationen
dc.subjectmultiple sclerosisen
dc.subjectnonhumanen
dc.subjectpathogenesisen
dc.subjectpriority journalen
dc.subjectprotein expressionen
dc.subjectprotein targetingen
dc.subjectregulatory T lymphocyteen
dc.subjectReviewen
dc.subjectT lymphocyte activationen
dc.subjectTh1 cellen
dc.subjectTh17 cellen
dc.subjectupregulationen
dc.subjectanimalen
dc.subjectdisease modelen
dc.subjectimmunologyen
dc.subjectmultiple sclerosisen
dc.subjectpathologyen
dc.subjectTh17 cellen
dc.subjectAnimalsen
dc.subjectDisease Models, Animalen
dc.subjectHumansen
dc.subjectHydroxymethylglutaryl-CoA Reductase Inhibitorsen
dc.subjectImmunologic Factorsen
dc.subjectMultiple Sclerosisen
dc.subjectTh17 Cellsen
dc.subjectSpringeren
dc.titleOn the immunoregulatory role of statins in multiple sclerosis: the effects on Th17 cellsen
dc.typeotheren


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