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Apolipoprotein ϵ4 allele is associated with frailty syndrome: Results from the hellenic longitudinal investigation of ageing and diet study
dc.creator | Mourtzi N., Ntanasi E., Yannakoulia M., Kosmidis M., Anastasiou C., Dardiotis E., Hadjigeorgiou G., Sakka P., Scarmeas N. | en |
dc.date.accessioned | 2023-01-31T09:02:02Z | |
dc.date.available | 2023-01-31T09:02:02Z | |
dc.date.issued | 2019 | |
dc.identifier | 10.1093/ageing/afz098 | |
dc.identifier.issn | 00020729 | |
dc.identifier.uri | http://hdl.handle.net/11615/76801 | |
dc.description.abstract | Apolipoprotein (APOE) ϵ4 allele has been associated with a number of age-related diseases but previous studies failed to identify any link with Frailty syndrome. The aim of the present study is to investigate the association between APOE ϵ4 allele and frailty syndrome. We operationalised Frailty according to the Fried definition, and we determined the APOE genotype in 1234 participants of the hellenic longitudinal investigation of ageing and diet study. Logistic regression analyses were performed to examine the association between APOE ϵ4 allele and frailty. Models were adjusted for age, education, sex, presence (or absence) of hypertension, diabetes, myocardial infraction, coronary disease, congestive heart failure, arrhythmia or other heart disease, family history of dementia and current smoking. The same models were performed after exclusion of patients with dementia and participants with APOE ϵ2/ϵ4 genotype. In the fully adjusted model, carriers of APOE ϵ4 allele had 2.753 higher odds of frailty relative to non-carriers. After trichotomization of APOE genotype, APOE ϵ4 heterozygotes had 2.675 higher risk of frailty compared to non-carriers while exclusion of patients with dementia or/and APOE ϵ2/ϵ4 genotype did not alter the association. The APOE ϵ4 allele may be a significant biomarker of frailty with diagnostic and prognostic capacity. © 2019 The Author(s) 2019. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved. For permissions, please email: journals.permissions@oup.com. | en |
dc.language.iso | en | en |
dc.source | Age and Ageing | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85074184662&doi=10.1093%2fageing%2fafz098&partnerID=40&md5=e38d63abb7be06de7afb58f192c2e479 | |
dc.subject | apolipoprotein E4 | en |
dc.subject | apolipoprotein E4 | en |
dc.subject | aged | en |
dc.subject | aging | en |
dc.subject | APOE e4 gene | en |
dc.subject | Article | en |
dc.subject | cohort analysis | en |
dc.subject | congestive heart failure | en |
dc.subject | coronary artery disease | en |
dc.subject | cross-sectional study | en |
dc.subject | dementia | en |
dc.subject | diabetes mellitus | en |
dc.subject | disease association | en |
dc.subject | educational status | en |
dc.subject | family history | en |
dc.subject | frailty | en |
dc.subject | gene | en |
dc.subject | genetic association | en |
dc.subject | genotype | en |
dc.subject | groups by age | en |
dc.subject | heart arrhythmia | en |
dc.subject | heart disease | en |
dc.subject | heart infarction | en |
dc.subject | heterozygote | en |
dc.subject | human | en |
dc.subject | hypertension | en |
dc.subject | major clinical study | en |
dc.subject | priority journal | en |
dc.subject | retrospective study | en |
dc.subject | smoking | en |
dc.subject | age | en |
dc.subject | allele | en |
dc.subject | female | en |
dc.subject | frailty | en |
dc.subject | genetic association study | en |
dc.subject | genetic predisposition | en |
dc.subject | genetics | en |
dc.subject | Greece | en |
dc.subject | longitudinal study | en |
dc.subject | male | en |
dc.subject | risk factor | en |
dc.subject | statistical model | en |
dc.subject | very elderly | en |
dc.subject | Age Factors | en |
dc.subject | Aged | en |
dc.subject | Aged, 80 and over | en |
dc.subject | Alleles | en |
dc.subject | Apolipoprotein E4 | en |
dc.subject | Cross-Sectional Studies | en |
dc.subject | Female | en |
dc.subject | Frailty | en |
dc.subject | Genetic Association Studies | en |
dc.subject | Genetic Predisposition to Disease | en |
dc.subject | Greece | en |
dc.subject | Humans | en |
dc.subject | Logistic Models | en |
dc.subject | Longitudinal Studies | en |
dc.subject | Male | en |
dc.subject | Retrospective Studies | en |
dc.subject | Risk Factors | en |
dc.subject | Oxford University Press | en |
dc.title | Apolipoprotein ϵ4 allele is associated with frailty syndrome: Results from the hellenic longitudinal investigation of ageing and diet study | en |
dc.type | journalArticle | en |
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