Todo DSpace

Mostrar el registro sencillo del ítem

IL-10-producing regulatory B cells (B10 cells), IL-17 + T cells and autoantibodies in systemic sclerosis

dc.creatorMavropoulos A., Liaskos C., Simopoulou T., Bogdanos D.P., Sakkas L.I.en
dc.date.accessioned2023-01-31T08:58:09Z
dc.date.available2023-01-31T08:58:09Z
dc.date.issued2017
dc.identifier10.1016/j.clim.2017.04.013
dc.identifier.issn15216616
dc.identifier.urihttp://hdl.handle.net/11615/76443
dc.description.abstractWe aimed to analyze IL-10 + Breg (B10) cells, found to be reduced in systemic sclerosis (SSc), in relation to SSc-specific autoAbs and IL-17 + and IFNγ + T cells in SSc. Peripheral blood B10 cells from 26 patients with SSc positive for anti-Topo I or anti-Cen autoAbs, and 12 healthy controls (HC) were studied by flow cytometry. IL-17 + and IFNγ + T cells were also studied. B10 cells did not correlate with anti-Topo I or anti-Cen Ab levels but were inversely correlated with IL-17 + CD3 + cells and IFNγ + CD3 + cells. IL-17 + CD3 + cells did not correlate with autoAb levels, but IFN-γ + CD3 + cells were inversely correlated with anti-Topo I levels. In conclusion, in SSc, B10 cells did not correlate with SSc-specific autoAbs and exhibited an inverse correlation with IL-17 + T cells and IFNγ + T cells. © 2017 Elsevier Inc.en
dc.language.isoenen
dc.sourceClinical Immunologyen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85019261317&doi=10.1016%2fj.clim.2017.04.013&partnerID=40&md5=088d99c7639ce880f8be5fb93026570c
dc.subjectautoantibodyen
dc.subjectazathioprineen
dc.subjectbosentanen
dc.subjectCD3 antigenen
dc.subjectCen autoantibodyen
dc.subjectgamma interferonen
dc.subjectinterleukin 10en
dc.subjectinterleukin 17en
dc.subjectmethotrexateen
dc.subjectmycophenolate mofetilen
dc.subjectprednisoneen
dc.subjectTopo I autoantibodyen
dc.subjectunclassified drugen
dc.subjectantinuclear antibodyen
dc.subjectautoantibodyen
dc.subjectCD3 antigenen
dc.subjectcentromere antibodyen
dc.subjectDNA topoisomeraseen
dc.subjectgamma interferonen
dc.subjectIFNG protein, humanen
dc.subjectIL10 protein, humanen
dc.subjectinterleukin 10en
dc.subjectinterleukin 17en
dc.subjectadulten
dc.subjectageden
dc.subjectantibody blood levelen
dc.subjectArticleen
dc.subjectCD3+ T lymphocyteen
dc.subjectclinical articleen
dc.subjectcontrolled studyen
dc.subjectcytokine productionen
dc.subjectfemaleen
dc.subjectflow cytometryen
dc.subjecthumanen
dc.subjecthuman cellen
dc.subjectmaleen
dc.subjectperipheral blood mononuclear cellen
dc.subjectpriority journalen
dc.subjectregulatory B lymphocyteen
dc.subjectsystemic sclerosisen
dc.subjectT lymphocyteen
dc.subjectcase control studyen
dc.subjectimmunologyen
dc.subjectmiddle ageden
dc.subjectregulatory B lymphocyteen
dc.subjectsystemic sclerosisen
dc.subjectT lymphocyteen
dc.subjectyoung adulten
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAntibodies, Antinuclearen
dc.subjectAutoantibodiesen
dc.subjectB-Lymphocytes, Regulatoryen
dc.subjectCase-Control Studiesen
dc.subjectCD3 Complexen
dc.subjectDNA Topoisomerases, Type Ien
dc.subjectFemaleen
dc.subjectFlow Cytometryen
dc.subjectHumansen
dc.subjectInterferon-gammaen
dc.subjectInterleukin-10en
dc.subjectInterleukin-17en
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectScleroderma, Systemicen
dc.subjectT-Lymphocytesen
dc.subjectYoung Adulten
dc.subjectAcademic Press Inc.en
dc.titleIL-10-producing regulatory B cells (B10 cells), IL-17 + T cells and autoantibodies in systemic sclerosisen
dc.typejournalArticleen


Ficheros en el ítem

FicherosTamañoFormatoVer

No hay ficheros asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem