Establishment of Patient-derived Orthotopic Xenografts (PDX) as Models for Pancreatic Ductal Adenocarcinoma
Datum
2022Language
en
Schlagwort
Zusammenfassung
Background/Aim: Pancreatic cancer (PC) is one of the leading causes of cancer-related death. The purpose of the present study was to establish a patientderived orthotopic xenograft model (PDOX) for pancreatic ductal adenocarcinoma (PDAC), thus providing a tumor microenvironment resembling that of the human pancreas to identify novel potential biomarkers and treatment regimens. Materials and Methods: PDAC tissue samples were received from 35 patients, following informed consent, and three mouse strains were implemented. Results: Successful PDOX engraftment was performed in nonobese diabetic/severe combined immunodeficient (NOD/SCID) and NOD/SCID gamma (NSG) mice. Nonetheless, we found a higher rate of successful engraftment and tumor growth in NSG compared to NOD/SCID mice, possibly owning to the different level of immunosuppression and more specifically of the natural killer cells presence. Conclusion: Our suggested PDOX model represents a preclinical cancer research model with a high affinity for the patient's tumor microenvironment, thus enabling the acceleration of PDAC research. © 2022 International Institute of Anticancer Research. All rights reserved.
Collections
Verwandte Dokumente
Anzeige der Dokumente mit ähnlichem Titel, Autor, Urheber und Thema.
-
Global, regional, and national age-sex specifc mortality for 264 causes of death, 1980-2016: A systematic analysis for the Global Burden of Disease Study 2016
Naghavi M., Abajobir A.A., Abbafati C., Abbas K.M., Abd-Allah F., Abera S.F., Aboyans V., Adetokunboh O., Ärnlöv J., Afshin A., Agrawal A., Kiadaliri A.A., Ahmadi A., Ahmed M.B., Aichour A.N., Aichour I., Aichour M.T.E., Aiyar S., Al-Eyadhy A., Alahdab F., Al-Aly Z., Alam K., Alam N., Alam T., Alene K.A., Ali S.D., Alizadeh-Navaei R., Alkaabi J.M., Alkerwi A., Alla F., Allebeck P., Allen C., Al-Raddadi R., Alsharif U., Altirkawi K.A., Alvis-Guzman N., Amare A.T., Amini E., Ammar W., Amoako Y.A., Anber N., Andersen H.H., Andrei C.L., Androudi S., Ansari H., Antonio C.A.T., Anwari P., Arora M., Artaman A., Aryal K.K., Asayesh H., Asgedom S.W., Atey T.M., Avila-Burgos L., Avokpaho E.F.G.A., Awasthi A., Quintanilla B.P.A., Béjot Y., Babalola T.K., Bacha U., Balakrishnan K., Barac A., Barboza M.A., Barker-Collo S.L., Barquera S., Barregard L., Barrero L.H., Baune B.T., Bedi N., Beghi E., Bekele B.B., Bell M.L., Bennett J.R., Bensenor I.M., Berhane A., Bernabé E., Betsu B.D., Beuran M., Bhatt S., Biadgilign S., Bienhof K., Bikbov B., Bisanzio D., Bourne R.R.A., Breitborde N.J.K., Bulto L.N.B., Bumgarner B.R., Butt Z.A., Cárdenas R., Cahuana-Hurtado L., Cameron E., Campuzano J.C., Car J., Carrero J.J., Carter A., Casey D.C., Castañeda-Orjuela C.A., Catalá-López F., Charlson F.J., Chibueze C.E., Chimed-Ochir O., Chisumpa V.H., Chitheer A.A., Christopher D.J., Ciobanu L.G., Cirillo M., Cohen A.J., Colombara D., Cooper C., Cowie B.C., Criqui M.H., Dandona L., Dandona R., Dargan P.I., Das Neves J., Davitoiu D.V., Davletov K., De Courten B., Degenhardt L., Deiparine S., Deribe K., Deribew A., Dey S., Dicker D., Ding E.L., Djalalinia S., Do H.P., Doku D.T., Douwes-Schultz D., Driscoll T.R., Dubey M., Duncan B.B., Echko M., El-Khatib Z.Z., Ellingsen C.L., Enayati A., Erskine H.E., Eskandarieh S., Esteghamati A., Ermakov S.P., Estep K., Sa Farinha C.S., Faro A., Farzadfar F., Feigin V.L., Fereshtehnejad S.-M., Fernandes J.C., Ferrari A.J., Feyissa T.R., Filip I., Finegold S., Fischer F., Fitzmaurice C., Flaxman A.D., Foigt N., Frank T., Fraser M., Fullman N., Fürst T., Furtado J.M., Gakidou E., Garcia-Basteiro A.L., Gebre T., Gebregergs G.B., Gebrehiwot T.T., Gebremichael D.Y., Geleijnse J.M., Genova-Maleras R., Gesesew H.A., Gething P.W., Gillum R.F., Ginawi I.A.M., Giref A.Z., Giroud M., Giussani G., Godwin W.W., Gold A.L., Goldberg E.M., Gona P.N., Gopalani S.V., Gouda H.N., Goulart A.C., Griswold M., Gupta P.C., Gupta R., Gupta T., Gupta V., Haagsma J.A., Hafezi-Nejad N., Hailu A.D., Hailu G.B., Hamadeh R.R., Hambisa M.T., Hamidi S., Hammami M., Hancock J., Handal A.J., Hankey G.J., Hao Y., Harb H.L., Hareri H.A., Hassanvand M.S., Havmoeller R., Hay S.I., He F., Hedayati M.T., Henry N.J., Heredia-Pi I.B., Herteliu C., Hoek H.W., Horino M., Horita N., Hosgood H.D., Hostiuc S., Hotez P.J., Hoy D.G., Huynh C., Iburg K.M., Ikeda C., Ileanu B.V., Irenso A.A., Irvine C.M.S., Jürisson M., Jacobsen K.H., Jahanmehr N., Jakovljevic M.B., Javanbakht M., Jayaraman S.P., Jeemon P., Jha V., John D., Johnson C.O., Johnson S.C., Jonas J.B., Kabir Z., Kadel R., Kahsay A., Kamal R., Karch A., Karimi S.M., Karimkhani C., Kasaeian A., Kassaw N.A., Kassebaum N.J., Katikireddi S.V., Kawakami N., Keiyoro P.N., Kemmer L., Kesavachandran C.N., Khader Y.S., Khan E.A., Khang Y.-H., Khoja A.T.A., Khosravi A., Khosravi M.H., Khubchandani J., Kieling C., Kievlan D., Kim D., Kim Y.J., Kimokoti R.W., Kinfu Y., Kissoon N., Kivimaki M., Knudsen A.K., Kopec J.A., Kosen S., Koul P.A., Koyanagi A., Defo B.K., Kulikof X.R., Kumar G.A., Kumar P., Kutz M., Kyu H.H., Lal D.K., Lalloo R., Lambert T.L.N., Lan Q., Lansingh V.C., Larsson A., Lee P.H., Leigh J., Leung J., Levi M., Li Y., Kappe D.L., Liang X., Liben M.L., Lim S.S., Liu A., Liu P.Y., Liu Y., Lodha R., Logroscino G., Lorkowski S., Lotufo P.A., Lozano R., Lucas T.C.D., Ma S., Macarayan E.R.K., Maddison E.R., Abd El Razek M.M., Majdan M., Majdzadeh R., Majeed A., Malekzadeh R., Malhotra R., Malta D.C., Manguerra H., Manyazewal T., Mapoma C.C., Marczak L.B., Markos D., Martinez-Raga J., Martins-Melo F.R., Martopullo I., McAlinden C., McGaughey M., McGrath J.J., Mehata S., Meier T., Meles K.G., Memiah P., Memish Z.A., Mengesha M.M., Mengistu D.T., Menota B.G., Mensah G.A., Meretoja A., Meretoja T.J., Millear A., Miller T.R., Minnig S., Mirarefn M., Mirrakhimov E.M., Misganaw A., Mishra S.R., Mohammad K.A., Mohammadi A., Mohammed S., Mokdad A.H., Mola G.L.D., Mollenkopf S.K., Molokhia M., Monasta L., Hernandez J.C.M., Montico M., Mooney M.D., Moradi-Lakeh M., Moraga P., Morawska L., Morrison S.D., Morozof C., Mountjoy-Venning C., Mruts K.B., Muller K., Murthy G.V.S., Musa K.I., Nachega J.B., Naheed A., Naldi L., Nangia V., Nascimento B.R., Nasher J.T., Natarajan G., Negoi I., Ngunjiri J.W., Nguyen C.T., Nguyen G., Nguyen M., Nguyen Q.L., Nguyen T.H., Nichols E., Ningrum D.N.A., Nong V.M., Noubiap J.J.N., Ogbo F.A., Oh I.-H., Okoro A., Olagunju A.T., Olsen H.E., Olusanya B.O., Olusanya J.O., Ong K., Opio J.N., Oren E., Ortiz A., Osman M., Ota E., Mahesh P.A., Pacella R.E., Pakhale S., Pana A., Panda B.K., Jonas S., Papachristou C., Park E.-K., Patten S.B., Patton G.C., Paudel D., Paulson K., Pereira D.M., Perez-Ruiz F., Perico N., Pervaiz A., Petzold M., Phillips M.R., Pigott D.M., Pinho C., Plass D., Pletcher M.A., Polinder S., Postma M.J., Pourmalek F., Purcell C., Qorbani M., Radfar A., Rafay A., Rahimi-Movaghar V., Rahman M., Ur Rahman M.H., Rai R.K., Ranabhat C.L., Rankin Z., Rao P.C., Rath G.K., Rawaf S., Ray S.E., Rehm J., Reiner R.C., Reitsma M.B., Remuzzi G., Rezaei S., Rezai M.S., Rokni M.B., Ronfani L., Roshandel G., Roth G.A., Rothenbacher D., Ruhago G.M., Rizwan S.A., Saadat S., Sachdev P.S., Sadat N., Safdarian M., Saf S., Safiri S., Sagar R., Sahathevan R., Salama J., Salamati P., Salomon J.A., Samy A.M., Sanabria J.R., Sanchez-Niño M.D., Santomauro D., Santos I.S., Milicevic M.M.S., Sartorius B., Satpathy M., Shahraz S., Schmidt M.I., Schneider I.J.C., Schulhofer-Wohl S., Schutte A.E., Schwebel D.C., Schwendicke F., Sepanlou S.G., Servan-Mori E.E., Shackelford K.A., Shaikh M.A., Shamsipour M., Shamsizadeh M., Islam S.M.S., Sharma J., Sharma R., She J., Sheikhbahaei S., Shey M., Shi P., Shields C., Shigematsu M., Shiri R., Shirude S., Shiue I., Shoman H., Shrime M.G., Sigfusdottir I.D., Silpakit N., Silva J.P., Singh A., Singh J.A., Skiadaresi E., Sligar A., Smith A., Smith D.L., Smith M., Sobaih B.H.A., Soneji S., Sorensen R.J.D., Soriano J.B., Sreeramareddy C.T., Srinivasan V., Stanaway J.D., Stathopoulou V., Steel N., Stein D.J., Steiner C., Steinke S., Stokes M.A., Strong M., Strub B., Subart M., Sufyan M.B., Sunguya B.F., Sur P.J., Swaminathan S., Sykes B.L., Tabarés-Seisdedos R., Tadakamadla S.K., Takahashi K., Takala J.S., Talongwa R.T., Tarawneh M.R., Tavakkoli M., Taveira N., Tegegne T.K., Tehrani-Banihashemi A., Temsah M.-H., Terkawi A.S., Thakur J.S., Thamsuwan O., Thankappan K.R., Thomas K.E., Thompson A.H., Thomson A.J., Thrift A.G., Tobe-Gai R., Topor-Madry R., Torre A., Tortajada M., Towbin J.A., Tran B.X., Troeger C., Truelsen T., Tsoi D., Tuzcu E.M., Tyrovolas S., Ukwaja K.N., Undurraga E.A., Updike R., Uthman O.A., Uzochukwu B.S.C., Van Boven J.F.M., Vasankari T., Venketasubramanian N., Violante F.S., Vlassov V.V., Vollset S.E., Vos T., Wakayo T., Wallin M.T., Wang Y.-P., Weiderpass E., Weintraub R.G., Weiss D.J., Werdecker A., Westerman R., Whetter B., Whiteford H.A., Wijeratne T., Wiysonge C.S., Woldeyes B.G., Wolfe C.D.A., Woodbrook R., Workicho A., Xavier D., Xiao Q., Xu G., Yaghoubi M., Yakob B., Yano Y., Yaseri M., Yimam H.H., Yonemoto N., Yoon S.-J., Yotebieng M., Younis M.Z., Zaidi Z., El Sayed Zaki M., Zegeye E.A., Zenebe Z.M., Zerfu T.A., Zhang A.L., Zhang X., Zipkin B., Zodpey S., Lopez A.D., Murray C.J.L., GBD 2016 Causes of Death Collaborators (2017)Background: Monitoring levels and trends in premature mortality is crucial to understanding how societies can address prominent sources of early death. The Global Burden of Disease 2016 Study (GBD 2016) provides a comprehensive ... -
Alterations of microRNAs in solid cancers and their prognostic value
Chira, P.; Vareli, K.; Sainis, I.; Papandreou, C.; Briasoulis, E. (2010)MicroRNAs (miRNAs) are evolutionarily conserved, naturally abundant, small, regulatory non-coding RNAs that inhibit gene expression at the post-transcriptional level in a sequence-specific manner. Each miRNA represses the ... -
Treatment of lung cancer
Rapti, A.; Kerenidi, T.; Zarogoulidis, K. (2012)